CSN3 (gene)

CSN3
Identifiers
Aliases	CSN3 , CSN10, CSNK, KCA, CNS10, casein kappa
External IDs	OMIM: 601695; MGI: 107461; HomoloGene: 3818; GeneCards: CSN3; OMA:CSN3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q13.3 Start 70,238,382 bp [1] End 70,251,474 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 E1|5 43.56 cM Start 88,073,438 bp [2] End 88,080,524 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell minor salivary glands olfactory zone of nasal mucosa tonsil epithelium of lactiferous gland gonad lactiferous duct lymph node islet of Langerhans fallopian tube Top expressed in lactiferous gland molar parotid gland right ventricle embryo lacrimal gland muscle of thigh lip olfactory epithelium vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component extracellular region extracellular space Biological process protein stabilization lactation transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1448 12994 Ensembl ENSG00000171209 ENSMUSG00000001622 UniProt P07498 P06796 RefSeq (mRNA) NM_005212 NM_001394997 NM_007786 NM_001356570 NM_001356571 RefSeq (protein) NP_005203 NP_031812 NP_001343499 NP_001343500 Location (UCSC) Chr 4: 70.24 – 70.25 Mb Chr 5: 88.07 – 88.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kappa-casein is a protein that in humans is encoded by the CSN3 gene. ^{[5] [6] [7]}

Interactions

CSN3 (gene) has been shown to interact with EIF3S6. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000171209 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001622 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Edlund A, Johansson T, Leidvik B, Hansson L (Nov 1996). "Structure of the human kappa-casein gene". Gene. 174 (1): 65–9. doi:10.1016/0378-1119(96)00351-4. PMID   8863730.
6. Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID   9050925. S2CID   8299892.
7. "Entrez Gene: CSN3 casein kappa".
8. Hoareau Alves, Karine; Bochard Valérie; Réty Stéphane; Jalinot Pierre (Sep 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3). Netherlands: 15–21. doi: 10.1016/S0014-5793(02)03147-2 . ISSN   0014-5793. PMID   12220626. S2CID   39308598.

External links

• Human CSN3 genome location and CSN3 gene details page in the UCSC Genome Browser .

Further reading

• Bergström S, Hansson L, Hernell O, et al. (1993). "Cloning and sequencing of human kappa-casein cDNA". DNA Seq. 3 (4): 245–6. doi:10.3109/10425179209034024. PMID   1296818.
• Brignon G, Chtourou A, Ribadeau-Dumas B (1985). "Preparation and amino acid sequence of human kappa-casein". FEBS Lett. 188 (1): 48–54. doi: 10.1016/0014-5793(85)80872-3 . PMID   4018271. S2CID   83551753.
• Fiat AM, Jollès J, Aubert JP, et al. (1981). "Localisation and importance of the sugar part of human casein". Eur. J. Biochem. 111 (2): 333–9. doi: 10.1111/j.1432-1033.1980.tb04946.x . PMID   7460900.
• Plowman JE, Creamer LK, Liddell MJ, Cross JJ (1999). "Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy". J. Dairy Res. 66 (1): 53–63. doi:10.1017/S0022029998003318. PMID   10191473. S2CID   22589486.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID   11329013. S2CID   25064683.
• Benítez MJ, Cochet C, Jiménez JS (2002). "A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin". Mol. Cell. Biochem. 227 (1–2): 31–6. doi:10.1023/A:1013140220121. PMID   11827172. S2CID   19295218.
• Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi: 10.3168/jds.S0022-0302(02)74200-8 . PMID   12146463.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kim YJ, Park S, Oh YK, et al. (2005). "Purification and characterization of human caseinomacropeptide produced by a recombinant Saccharomyces cerevisiae". Protein Expr. Purif. 41 (2): 441–6. doi:10.1016/j.pep.2005.02.021. PMID   15866733.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.