CSRP2BP

Last updated

KAT14
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KAT14 , ATAC2, CRP2BP, PRO1194, dJ717M23.1, CSRP2BP, lysine acetyltransferase 14
External IDs OMIM: 617501; MGI: 1917264; HomoloGene: 10745; GeneCards: KAT14; OMA:KAT14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

57325

228714

Ensembl

ENSG00000149474

ENSMUSG00000027425

UniProt

Q9H8E8

Q8CID0

RefSeq (mRNA)

NM_020536
NM_177926

NM_001166640
NM_181417

RefSeq (protein)

NP_065397
NP_001371121

NP_001160112
NP_852082

Location (UCSC) Chr 20: 18.14 – 18.19 Mb Chr 2: 144.21 – 144.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CSRP2 binding protein is a protein that in humans is encoded by the CSRP2BP gene. [5]

Contents

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [5]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149474 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027425 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CSRP2 binding protein" . Retrieved 2011-09-20.

Further reading

Weiskirchen R, Gressner AM (August 2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochemical and Biophysical Research Communications. 274 (3): 655–663. doi:10.1006/bbrc.2000.3187. PMID   10924333.Wang YL, Faiola F, Xu M, Pan S, Martinez E (December 2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". The Journal of Biological Chemistry. 283 (49): 33808–33815. doi: 10.1074/jbc.M806936200 . PMC   2590711 . PMID   18838386.Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, et al. (March 2009). "The double-histone-acetyltransferase complex ATAC is essential for mammalian development". Molecular and Cellular Biology. 29 (5): 1176–1188. doi:10.1128/MCB.01599-08. PMC   2643826 . PMID   19103755.Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, et al. (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa". Molecular Psychiatry. 16 (9): 949–959. doi:10.1038/mp.2010.107. PMID   21079607. S2CID   15188506.

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