CSTF2T

CSTF2T
Identifiers
Aliases	CSTF2T , CstF-64T, cleavage stimulation factor subunit 2, tau variant, cleavage stimulation factor subunit 2 tau variant
External IDs	OMIM: 611968 MGI: 1932622 HomoloGene: 80230 GeneCards: CSTF2T
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q21.1 Start 51,695,486 bp [1] End 51,699,595 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C1 Start 31,060,237 bp [2] End 31,064,469 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell germinal epithelium parietal pleura pons islet of Langerhans ganglionic eminence corpus callosum subthalamic nucleus skeletal muscle tissue biceps brachii Top expressed in pineal gland medial ganglionic eminence olfactory tubercle habenula subiculum cerebellar vermis median eminence atrium medullary collecting duct paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding nucleic acid binding RNA binding Cellular component mRNA cleavage and polyadenylation specificity factor complex intracellular anatomical structure nucleus nucleoplasm Biological process mRNA processing pre-mRNA cleavage required for polyadenylation mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23283 83410 Ensembl ENSG00000177613 ENSMUSG00000053536 UniProt Q9H0L4 Q8C7E9 RefSeq (mRNA) NM_015235 NM_031249 RefSeq (protein) NP_056050 NP_112539 Location (UCSC) Chr 10: 51.7 – 51.7 Mb Chr 19: 31.06 – 31.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage stimulation factor 64 kDa subunit, tau variant is a protein that in humans is encoded by the CSTF2T gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000177613 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053536 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dass B, McDaniel L, Schultz RA, Attaya E, MacDonald CC (Oct 2002). "The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein tauCstF-64, lacks introns and may be associated with male sterility". Genomics. 80 (5): 509–14. doi:10.1016/S0888-7543(02)96862-X. PMID   12408968.
6. Dass B, McMahon KW, Jenkins NA, Gilbert DJ, Copeland NG, MacDonald CC (May 2001). "The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice". J Biol Chem. 276 (11): 8044–50. doi: 10.1074/jbc.M009091200 . PMID   11113135.
7. "Entrez Gene: CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant".

External links

• Human CSTF2T genome location and CSTF2T gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Pérez Cañadillas JM, Varani G (2003). "Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein". EMBO J. 22 (11): 2821–30. doi:10.1093/emboj/cdg259. PMC   156756 . PMID   12773396.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhao X, Oberg D, Rush M, et al. (2005). "A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein". J. Virol. 79 (7): 4270–88. doi:10.1128/JVI.79.7.4270-4288.2005. PMC   1061554 . PMID   15767428.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.