CTNNBL1

CTNNBL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CB8, 4CB9, 4CBA, 4HM9, 4HNM, 4MFU, 4MFV
Identifiers
Aliases	CTNNBL1 , C20orf33, NAP, P14L, PP8304, dJ633O20.1, catenin beta like 1
External IDs	OMIM: 611537 MGI: 1913892 HomoloGene: 12003 GeneCards: CTNNBL1
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.23 Start 37,693,955 bp [1] End 37,872,129 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 H1|2 78.4 cM Start 157,737,401 bp [2] End 157,891,614 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • enzyme binding • GO:0001948 protein binding Cellular component • cytoplasm • spliceosomal complex • membrane • nucleus • Prp19 complex • nucleoplasm Biological process • positive regulation of apoptotic process • mRNA splicing, via spliceosome • mRNA processing • somatic diversification of immunoglobulins • apoptotic process • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56259	66642
Ensembl	ENSG00000132792	ENSMUSG00000027649
UniProt	Q8WYA6	Q9CWL8
RefSeq (mRNA)	NM_001281495 NM_030877	NM_025680
RefSeq (protein)	NP_001268424 NP_110517	NP_079956
Location (UCSC)	Chr 20: 37.69 – 37.87 Mb	Chr 2: 157.74 – 157.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. ^{[5] [6]}

The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. ^[6] It is a housekeeping gene.

References

1. GRCh38: Ensembl release 89: ENSG00000132792 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027649 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jabbour L, Welter JF, Kollar J, Hering TM (Mar 2003). "Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis". Genomics. 81 (3): 292–303. doi:10.1016/S0888-7543(02)00038-1. PMID   12659813.
6. "Entrez Gene: CTNNBL1 catenin, beta like 1".

External links

• Human CTNNBL1 genome location and CTNNBL1 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi: 10.1016/j.ygeno.2006.04.003 . PMID   16730941.