CTPS2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CTPS2 , CTP synthase 2, GATD5B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300380 MGI: 1933185 HomoloGene: 115908 GeneCards: CTPS2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene. [5] [6]
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate.
This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.
Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [6]
Arrestin-C, also known as retinal cone arrestin-3, is a protein that in humans is encoded by the ARR3 gene.
Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.
Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.
Nuclear receptor-binding protein is a protein that in humans is encoded by the NRBP1 gene.
Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.
Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.
Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.
Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.
Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene.
BET1 homolog is a protein that in humans is encoded by the BET1 gene.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is a protein that in humans is encoded by the GNG11 gene.
Asparaginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the NARS gene.
Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene.
Serine/threonine-protein kinase, Intestinal cell kinase or ICK is an enzyme that in humans is encoded by the ICK gene.
Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene.
Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene.
Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme, in particular a dual-specificity kinase, that in humans is encoded by the DYRK2 gene.
Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.
Ras-related protein Rab-33A is a protein that in humans is encoded by the RAB33A gene.
Rhox homeobox family member 1 is a protein that in humans is encoded by the RHOXF1 gene.