CTPS2

CTPS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V4U, 2VKT, 3IHL
Identifiers
Aliases	CTPS2 , CTP synthase 2, GATD5B
External IDs	OMIM: 300380 MGI: 1933185 HomoloGene: 115908 GeneCards: CTPS2
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.2 Start 16,587,999 bp [1] End 16,712,936 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F4 Start 161,684,234 bp [2] End 161,815,504 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa body of pancreas canal of the cervix ganglionic eminence Achilles tendon duodenum right uterine tube visceral pleura endometrium minor salivary gland Top expressed in external carotid artery internal carotid artery facial motor nucleus proximal tubule neural tube white adipose tissue superior cervical ganglion blood supraoptic nucleus ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ligase activity nucleotide binding protein binding ATP binding CTP synthase activity identical protein binding Cellular component cytosol cytoplasm cytoophidium Biological process pyrimidine nucleotide metabolic process glutamine metabolic process 'de novo' CTP biosynthetic process pyrimidine nucleotide biosynthetic process nucleobase-containing small molecule interconversion CTP biosynthetic process pyrimidine nucleobase biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56474 55936 Ensembl ENSG00000047230 ENSMUSG00000031360 UniProt Q9NRF8 P70303 RefSeq (mRNA) NM_001144002 NM_019857 NM_175859 NM_001168568 NM_001168569 NM_001168571 NM_018737 NM_001358398 RefSeq (protein) NP_001137474 NP_062831 NP_787055 NP_001162040 NP_001162041 NP_001162043 NP_061207 NP_001345327 Location (UCSC) Chr X: 16.59 – 16.71 Mb Chr X: 161.68 – 161.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene. ^{[5] [6]}

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate.

This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.

Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000047230 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031360 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Kuilenburg AB, Meinsma R, Vreken P, Waterham HR, van Gennip AH (Oct 2000). "Identification of a cDNA encoding an isoform of human CTP synthetase". Biochim Biophys Acta. 1492 (2–3): 548–52. doi:10.1016/s0167-4781(00)00141-x. PMID   10899599.
6. "Entrez Gene: CTPS2 CTP synthase II".

External links

• Human CTPS2 genome location and CTPS2 gene details page in the UCSC Genome Browser .

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Han GS, Sreenivas A, Choi MG, et al. (2006). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi: 10.1074/jbc.M509622200 . PMC   1400552 . PMID   16179339.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.