CTRL (gene)

CTRL
Identifiers
Aliases	CTRL , CTRL1, chymotrypsin like
External IDs	OMIM: 118888; MGI: 88558; HomoloGene: 37549; GeneCards: CTRL; OMA:CTRL - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 67,927,640 bp [1] End 67,932,365 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 53.06 cM Start 106,658,635 bp [2] End 106,660,494 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans testicle gonad granulocyte blood monocyte bone marrow spleen right hemisphere of cerebellum Top expressed in pyloric antrum islet of Langerhans duodenum morula choroid plexus of fourth ventricle embryo embryo mesenteric lymph nodes Paneth cell spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type endopeptidase activity hydrolase activity serine-type peptidase activity Cellular component extracellular space Biological process proteolysis protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1506 109660 Ensembl ENSG00000141086 ENSMUSG00000031896 UniProt P40313 Q9ER05 RefSeq (mRNA) NM_001907 NM_023182 RefSeq (protein) NP_001898 NP_075671 Location (UCSC) Chr 16: 67.93 – 67.93 Mb Chr 8: 106.66 – 106.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chymotrypsin-like protease CTRL-1 is an enzyme that in humans is encoded by the CTRL gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000141086 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031896 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Larsen F, Solheim J, Kristensen T, Kolsto AB, Prydz H (Feb 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID   8268911.
6. "Entrez Gene: CTRL chymotrypsin-like".

External links

• Human CTRL genome location and CTRL gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Heidtmann HH, Travis J (1994). "A novel chymotrypsin-like serine proteinase from human lung". Biol. Chem. Hoppe-Seyler. 374 (9): 871–5. doi:10.1515/bchm3.1993.374.7-12.871. PMID   8267879.
• Mastroianni N, De Fusco M, Zollo M, et al. (1996). "Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3)". Genomics. 35 (3): 486–93. doi:10.1006/geno.1996.0388. PMID   8812482.
• Reseland JE, Larsen F, Solheim J, et al. (1997). "A novel human chymotrypsin-like digestive enzyme". J. Biol. Chem. 272 (12): 8099–104. doi: 10.1074/jbc.272.12.8099 . PMID   9065485.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Lee M, Calabresi L, Chiesa G, et al. (2002). "Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux". Arterioscler. Thromb. Vasc. Biol. 22 (9): 1475–81. doi: 10.1161/01.ATV.0000029782.84357.68 . PMID   12231569. S2CID   12259302.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.