CYB5R1

CYB5R1
Identifiers
Aliases	CYB5R1 , B5R.1, B5R1, B5R2, NQO3A2, humb5R2, cytochrome b5 reductase 1
External IDs	OMIM: 608341; MGI: 1919267; HomoloGene: 96059; GeneCards: CYB5R1; OMA:CYB5R1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 202,961,873 bp [1] End 202,967,275 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 134,333,297 bp [2] End 134,339,478 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii gastrocnemius muscle glutes muscle of thigh deltoid muscle vastus lateralis muscle body of tongue Skeletal muscle tissue of rectus abdominis triceps brachii muscle tibialis anterior muscle Top expressed in stroma of bone marrow plantaris muscle triceps brachii muscle temporal muscle vastus lateralis muscle calvaria extraocular muscle sternocleidomastoid muscle muscle of thigh digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cytochrome-b5 reductase activity, acting on NAD(P)H oxidoreductase activity FAD binding Cellular component integral component of membrane extracellular exosome plasma membrane endoplasmic reticulum membrane membrane mitochondrion platelet alpha granule membrane Biological process steroid metabolic process sterol biosynthetic process positive regulation of protein targeting to mitochondrion lipid metabolism steroid biosynthetic process platelet degranulation bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51706 72017 Ensembl ENSG00000159348 ENSMUSG00000026456 UniProt Q9UHQ9 Q9DB73 RefSeq (mRNA) NM_016243 NM_028057 NM_001355133 RefSeq (protein) NP_057327 NP_082333 NP_001342062 Location (UCSC) Chr 1: 202.96 – 202.97 Mb Chr 1: 134.33 – 134.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene. ^{[5] [6] [7]}

Structure

The CYB5R1 gene is located on the 1st chromosome, with its specific location being 1q32.1. The gene contains 9 exons. ^[7] CYB5R1 encodes a 34.1 kDa protein that is composed of 305 amino acids; 56 peptides have been observed through mass spectrometry data. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000159348 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026456 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
6. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Dec 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi: 10.1073/pnas.96.26.14742 . PMC   24718 . PMID   10611283.
7. "Entrez Gene: CYB5R1 cytochrome b5 reductase 1".
8. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC   4076475 . PMID   23965338.
9. "NADH-cytochrome b5 reductase 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).^{[ permanent dead link ]}

External links

• Human CYB5R1 genome location and CYB5R1 gene details page in the UCSC Genome Browser .

Further reading

• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Qian W, Sun YL, Wang YH, Zhuang JH, Xie Y, Huang ZX (Oct 1998). "The influence of mutation at Glu44 and Glu56 of cytochrome b5 on the protein's stabilization and interaction between cytochrome c and cytochrome b5". Biochemistry. 37 (40): 14137–50. doi:10.1021/bi9805036. PMID   9760250.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.