CYB5R4

CYB5R4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LF5
Identifiers
Aliases	CYB5R4 , NCB5OR, cb5/cb5R, dJ676J13.1, cytochrome b5 reductase 4
External IDs	OMIM: 608343; MGI: 2386848; HomoloGene: 69207; GeneCards: CYB5R4; OMA:CYB5R4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q14.2 Start 83,859,656 bp [1] End 83,967,423 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E3.1 Start 86,904,067 bp [2] End 86,959,827 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sperm blood bone marrow granulocyte bone marrow cells right testis left testis appendix islet of Langerhans Top expressed in granulocyte ileum ganglionic eminence jejunum zygote quadriceps femoris muscle duodenum neural tube tail of embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity NAD(P)H oxidase H2O2-forming activity oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor heme binding metal ion binding cytochrome-b5 reductase activity, acting on NAD(P)H Cellular component perinuclear region of cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Biological process response to antibiotic insulin secretion detection of oxygen generation of precursor metabolites and energy glucose homeostasis superoxide metabolic process cell development bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51167 266690 Ensembl ENSG00000065615 ENSMUSG00000032872 UniProt Q7L1T6 Q3TDX8 RefSeq (mRNA) NM_016230 NM_024195 NM_001359962 RefSeq (protein) NP_057314 NP_077157 NP_001346891 Location (UCSC) Chr 6: 83.86 – 83.97 Mb Chr 9: 86.9 – 86.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene. ^{[5] [6]}

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000065615 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032872 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Jan 2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc Natl Acad Sci U S A. 96 (26): 14742–7. Bibcode:1999PNAS...9614742Z. doi: 10.1073/pnas.96.26.14742 . PMC   24718 . PMID   10611283.
6. "Entrez Gene: CYB5R4 cytochrome b5 reductase 4".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhu H, Larade K, Jackson TA, et al. (2004). "NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum". J. Biol. Chem. 279 (29): 30316–25. doi: 10.1074/jbc.M402664200 . PMC   3045664 . PMID   15131110.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Andersen G, Wegner L, Rose CS, et al. (2005). "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus". Diabetes. 53 (11): 2992–7. doi:10.2337/diabetes.53.11.2992. PMC   3044473 . PMID   15504981.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• Human CYB5R4 genome location and CYB5R4 gene details page in the UCSC Genome Browser .