CYM50308

Last updated

CYM50308
CYM50308 structure.png
Clinical data
ATC code
  • none
Identifiers
  • (5Z)-5-[[1-(2,4-difluorophenyl)-2,5-dimethylpyrrol-3-yl]methylidene]]-2-(2-methoxyethylimino)-3-methyl-1,3-thiazolidin-4-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
Formula C20H21F2N3O2S
Molar mass 405.46 g·mol−1
3D model (JSmol)
  • COCC\N=C1/S\C(=C/c2cc(C)n(c3ccc(F)cc3F)c2C)C(=O)N1C
  • InChI=1S/C20H21F2N3O2S/c1-12-9-14(13(2)25(12)17-6-5-15(21)11-16(17)22)10-18-19(26)24(3)20(28-18)23-7-8-27-4/h5-6,9-11H,7-8H2,1-4H3/b18-10-,23-20?
  • Key:BKQZKTRCUAWRHT-ONBPWHQPSA-N

CYM50308 (ML248) is a drug which acts as a selective agonist at the sphingosine-1-phosphate receptor S1PR4. It is used for research into the structure and function of the S1PR4 receptor, and has demonstrated potential applications for S1PR4 agonists in the treatment of asthma. [1] [2] [3]

References

  1. ↑ Burkard T, Dreis C, Herrero San Juan M, Huhn M, Weigert A, Pfeilschifter JM, et al. (2021). "Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes is Driven by S1P4". Frontiers in Immunology. 12 668884. doi: 10.3389/fimmu.2021.668884 . PMC   8421764 . PMID   34504486.
  2. ↑ Wang S, Tian Z, Lu Y, Huang Z, Fan Y, Li B, et al. (2023). "Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation". International Journal of Biological Sciences. 19 (5): 1597–1615. doi:10.7150/ijbs.80256. PMC   10086758 . PMID   37056936.
  3. ↑ Wieczorek I, Strosznajder RP (2024). "S1P receptor modulators affect the toxicity of amyloid β oligomers in microglial and neuronal cells". Folia Neuropathologica. 62 (4): 348–361. doi: 10.5114/fn.2024.145758 . PMID   39963030.
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