Calcium citrate malate

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Calcium citrate malate [1]
Calcium citrate malate.png
Identifiers
3D model (JSmol)
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EC Number
  • 604-299-4
PubChem CID
UNII
Properties
(C6H7O7)x·(C4H5O5)y·(Ca2+)z
Molar mass Variable
AppearanceWhite solid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Calcium citrate malate is a water-soluble calcium supplement. It is the calcium salt of citric acid and malic acid with variable composition.

Calcium citrate malate's bioavailability stems from its water-solubility and its method of dissolution. When dissolved, it releases calcium ions and a calcium citrate complex. Calcium ions are absorbed directly into intestinal cells, and the citrate complex enters the body through paracellular absorption.[ citation needed ]

Calcium citrate malate is similar to calcium malate and other calcium salts. The European Food Safety Authority has concluded that calcium citrate malate is "slightly more bioavailable" than other forms of calcium supplementation. [2]

Related Research Articles

Calcium Chemical element with atomic number 20

Calcium is a chemical element with the symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to its heavier homologues strontium and barium. It is the fifth most abundant element in Earth's crust and the third most abundant metal, after iron and aluminium. The most common calcium compound on Earth is calcium carbonate, found in limestone and the fossilised remnants of early sea life; gypsum, anhydrite, fluorite, and apatite are also sources of calcium. The name derives from Latin calx "lime", which was obtained from heating limestone.

Calcium carbonate Chemical compound

Calcium carbonate is a chemical compound with the formula CaCO3. It is a common substance found in rocks as the minerals calcite and aragonite (most notably as limestone, which is a type of sedimentary rock consisting mainly of calcite) and is the main component of pearls and the shells of marine organisms, snails, and eggs. Calcium carbonate is the active ingredient in agricultural lime and is created when calcium ions in hard water react with carbonate ions to create limescale. It has medical use as a calcium supplement or as an antacid, but excessive consumption can be hazardous and cause poor digestion.

Pantothenic acid

Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to in general synthesize and metabolize proteins, carbohydrates, and fats.

Citric acid Weak organic acid

Citric acid is a weak organic acid that has the molecular formula C6H8O7. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in the metabolism of all aerobic organisms.

Ethylenediaminetetraacetic acid

Ethylenediaminetetraacetic acid (EDTA) is an aminopolycarboxylic acid with the formula [CH2N(CH2CO2H)2]2. This white, water-soluble solid is widely used to bind to iron and calcium ions. It binds these ions as a hexadentate ("six-toothed") chelating agent. EDTA is produced as several salts, notably disodium EDTA, sodium calcium edetate, and tetrasodium EDTA.

Calcium ions (Ca2+) contribute to the physiology and biochemistry of organisms cell. They play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in fertilization. Many enzymes require calcium ions as a cofactor, including several of the coagulation factors. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.

Calcium hydroxide

Calcium hydroxide (traditionally called slaked lime) is an inorganic compound with the chemical formula Ca(OH)2. It is a colorless crystal or white powder and is produced when quicklime (calcium oxide) is mixed, or slaked with water. It has many names including hydrated lime, caustic lime, builders' lime, slack lime, cal, or pickling lime. Calcium hydroxide is used in many applications, including food preparation, where it has been identified as E number E526. Limewater is the common name for a saturated solution of calcium hydroxide.

Trisodium citrate

Trisodium citrate has the chemical formula of Na3C6H5O7. It is sometimes referred to simply as "sodium citrate", though sodium citrate can refer to any of the three sodium salts of citric acid. It possesses a saline, mildly tart flavor. It is mildly basic and can be used along with citric acid to make biologically compatible buffers.

Calcium citrate

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements. Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass. The tetrahydrate occurs in nature as the mineral Earlandite.

Assimilation is the process of absorption of vitamins, minerals, and other chemicals from food within the gastrointestinal tract. In humans this is always done with a chemical breakdown and physical breakdown. The second process of bio assimilation is the chemical alteration of substances in the bloodstream by the liver or cellular secretions. Although a few similar compounds can be absorbed in digestion bio assimilation, the bioavailability of many compounds is dictated by this second process since both the liver and cellular secretions can be very specific in their metabolic action. This second process is where the absorbed food reaches the cells via the liver.

Easy Cheese

Easy Cheese is the trademark for a processed cheese spread product distributed by Mondelēz International. It is also referred to as aerosol cheese, spray cheese or simply cheese in a can, and is similar to squeeze cheese. Easy Cheese is packaged in a metal can filled with air covered with a plastic cap that reveals a straight, flexible nozzle where the cheese is extruded.

Calcium lactate

Calcium lactate is a white crystalline salt with formula C
6
H
10
CaO
6
, consisting of two lactate anions H
3
C
(CHOH)CO
2
for each calcium cation Ca2+
. It forms several hydrates, the most common being the pentahydrate C
6
H
10
CaO
6
·5H
2
O
.

Tricalcium phosphate

Tricalcium phosphate (sometimes abbreviated TCP) is a calcium salt of phosphoric acid with the chemical formula Ca3(PO4)2. It is also known as tribasic calcium phosphate and bone phosphate of lime (BPL). It is a white solid of low solubility. Most commercial samples of "tricalcium phosphate" are in fact hydroxyapatite.

Magnesium citrate

Magnesium citrate is a magnesium preparation in salt form with citric acid in a 1:1 ratio. The name "magnesium citrate" is ambiguous and sometimes may refer to other salts such as trimagnesium citrate which has a magnesium:citrate ratio of 3:2.

Calcium formate

Calcium formate is the calcium salt of formic acid. It is also known as E238. Under this E number it is used as an animal feed preservative within EU, but not in foods intended for people.

Magnesium aspartate, the chelated magnesium salt of aspartic acid, it is a mineral supplement.

Magnesium malate

Magnesium malate, the magnesium salt of malic acid, is a mineral supplement often used for nutritional concerns. It is represented by the chemical formula C4H4MgO5 and has a molecular weight of 156.376 g/mol. Magnesium malate is discussed as being a more bioavailable form of magnesium, along with other forms such as citrate and glycinate.

Zinc <small>L</small>-aspartate

Zinc l-aspartate, often simply called zinc aspartate, is a chelated zinc supplement. Zinc aspartate is a salt of zinc with the amino acid aspartic acid.

Magnesium salts are available as a medication in a number of formulations. They are used to treat magnesium deficiency, low blood magnesium, eclampsia, and several other conditions. Magnesium is important to health.

References

  1. Calcium citrate malate at Jost Chemical
  2. "Calcium citrate malate as source for calcium for use in foods for Particular Nutritional Uses and in foods for the general population (including food supplements)" (PDF). The EFSA Journal. 612: 1–24. 2007. doi: 10.2903/j.efsa.2007.612 Scientific Opinion of the Panel on Food Additives, Flavourings, Processing aids and Materials in Contact with food (AFC)