Caldesmon

Last updated
CALD1
Identifiers
Aliases CALD1 , CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, caldesmon 1, h-CD
External IDs OMIM: 114213; HomoloGene: 137424; GeneCards: CALD1; OMA:CALD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004342
NM_033138
NM_033139
NM_033140
NM_033157

n/a

RefSeq (protein)

NP_004333
NP_149129
NP_149130
NP_149131
NP_149347

n/a

Location (UCSC) Chr 7: 134.74 – 134.97 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Caldesmon is a protein that in humans is encoded by the CALD1 gene. [3] [4]

Contents

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [4]

Immunochemistry

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000122786 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem. 266 (25): 16917–24. doi: 10.1016/S0021-9258(18)55390-4 . PMID   1885618.
  4. 1 2 "Entrez Gene: CALD1 caldesmon 1".

Further reading