Call-Exner bodies

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Call-Exner bodies marked with black circles in an intermediate-high magnification micrograph of a granulosa cell tumour, a type of sex cord stromal tumour. H&E stain. Call-Exner bodies.png
Call–Exner bodies marked with black circles in an intermediate-high magnification micrograph of a granulosa cell tumour, a type of sex cord stromal tumour. H&E stain.

Call–Exner bodies, giving a follicle-like appearance, are small eosinophilic fluid-filled punched out spaces between granulosa cells. [1] The granulosa cells are usually arranged haphazardly around the space.

Eosinophilic

Eosinophilic refers to the staining of certain tissues, cells, or organelles after they have been washed with eosin, a dye.

Granulosa cell cell

A granulosa cell or follicular cell is a somatic cell of the sex cord that is closely associated with the developing female gamete in the ovary of mammals.

They are pathognomonic for granulosa cell tumors.

Histologically, these tumors consists of monotonous islands of granulosa cells with "coffee-bean" nuclei. That same nuclear groove appearance noted in Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by nests of transitional epithelial cells (urothelial) with longitudinal nuclear grooves (coffee bean nuclei) in abundant fibrous stroma. [2]

Brenner tumour ovarian benign neoplasm that has material basis in the surface epithelium of the ovary

Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant.

They are composed of membrane-packaged secretion of granulosa cells and have relations to the formation of liquor folliculi which are seen among closely arranged granulosa cells.

They are named for Emma Louise Call (1847-1937), an American physician, and Sigmund Exner. [3] [4]

Emma Louise Call (1847–1937) was an American physician, and one of the first female physicians in the United States. Along with Sigmund Exner, she is one of the namesakes of Call-Exner bodies, a pathognomonic feature of granulosa cell tumors. These tumors are associated with ovarian cancers.

Sigmund Exner Austrian physiologist

Sigmund Exner was an Austrian physiologist born in Vienna.

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References

  1. thefreedictionary.com > Call–Exner body Citing: The American Heritage Medical Dictionary. Copyright 2007
  2. Ahr, A.; Arnold, G.; Göhring, U. J.; Costa, S.; Scharl, A.; Gauwerky, J. F. (July 1997). "Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. A case report". Acta Cytologica. 41 (4 Suppl): 1299–1304. doi:10.1159/000333524. ISSN   0001-5547. PMID   9990262.
  3. Archived version of the Call-Exner bodies page on Who Named It?
  4. Emma Louise Call and Sigmund Exner: Zur Kenntniss des Graafschen Follikels und des Corpus luteum beim Kaninchen. Sitzungsberichte der kaiserlichen Akademie der Wissenschaften. Mathematish naturwssenschaftliche Classe, Wien, 1875, 72: 321-328.