Carbohydrate (chondroitin 4) sulfotransferase 13

CHST13
Identifiers
Aliases	CHST13 , C4ST3, carbohydrate sulfotransferase 13, Carbohydrate (chondroitin 4) sulfotransferase 13
External IDs	OMIM: 610124 MGI: 1919047 HomoloGene: 44360 GeneCards: CHST13
Gene location (Human)
Chr.	Chromosome 3 (human)
End	126,543,291 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	90,302,167 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; monocyte; ; tibia; ; blood; ; spleen; ; kidney; ; bone marrow; ; oocyte; ; duodenum; ; right uterine tube;
	Top expressed in
	yolk sac; ; bone marrow; ; liver; ; left lobe of liver; ; blastocyst; ; proximal tubule; ; calvaria; ; spermatocyte; ; body of femur; ; cervix;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; N-acetylgalactosamine 4-O-sulfotransferase activity ; sulfotransferase activity ; chondroitin 4-sulfotransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	chondroitin sulfate biosynthetic process ; carbohydrate biosynthetic process ; carbohydrate metabolic process ; proteoglycan biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	166012
	71797
	ENSG00000180767
	ENSMUSG00000056643
	Q8NET6
	D3Z6E3
	NM_152889
	NM_027928
	NP_690849
	NP_082204
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 03, 2024

Carbohydrate (chondroitin 4) sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.^[5]

Function

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices.

Related Research Articles

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.

3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen is also known as HNK1 or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system.

Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Xylosyltransferase 2 is an enzyme that in humans is encoded by the XYLT2 gene.

Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180767 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056643 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Carbohydrate (chondroitin 4) sulfotransferase 13".

Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (September 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". The Journal of Biological Chemistry. 277 (38): 34766–72. doi: 10.1074/jbc.M204907200 . PMID 12080076.
Valente B, Campos PA, do Rosário VE, Silveira H (October 2010). "Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene. 104 (10): 687–9. doi:10.1016/j.trstmh.2010.05.005. PMID 20580388.
Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (June 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi: 10.1074/jbc.M002443200 . PMID 10781601.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180767 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056643 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Carbohydrate (chondroitin 4) sulfotransferase 13".

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Carbohydrate (chondroitin 4) sulfotransferase 13

Contents

Function

Related Research Articles

References

Further reading