The St. Joseph Valley Parkway is a freeway in the U.S. states of Indiana and Michigan, serving as a bypass route around Elkhart, Mishawaka, and South Bend in Indiana and Niles in Michigan. The freeway runs to the south and west of Elkhart and South Bend and Niles and consists of segments of U.S. Route 31 (US 31) and US 20; those two highway designations run concurrently at the southwestern rim of the South Bend metropolitan area. It continues north to run along the St. Joseph River valley.
Interstate 265 (I-265) is a 41.71-mile (67.13 km) Interstate Highway partially encircling the Louisville metropolitan area. Starting from I-65 in the southern part of Louisville, it runs through Jefferson County, Kentucky, crosses the Ohio River on the Lewis and Clark Bridge into Indiana, meets I-65 for a second time, and then proceeds westbound to terminate at the I-64 interchange.
U.S. Route 48 (US 48), also known as the incomplete Corridor H of the Appalachian Development Highway System, extends from Interstate 79 (I-79) in Weston, West Virginia, eastward across the crest of the Allegheny Mountains to I-81 in Strasburg, Virginia. It is planned to extend 157 miles (253 km) from northwestern Virginia to central West Virginia.
The Appalachian Development Highway System (ADHS) is a series of highway corridors in the Appalachia region of the eastern United States. The routes are designed as local and regional routes for improving economic development in the historically isolated region. It was established as part of the Appalachian Regional Development Act of 1965, and has been repeatedly supplemented by various federal and state legislative and regulatory actions. The system consists of a mixture of state, U.S., and Interstate routes. The routes are formally designated as "corridors" and assigned a letter. Signage of these corridors varies from place to place, but where signed are often done so with a distinctive blue-colored sign.
The William H. Natcher Bridge is a cable-stayed bridge that carries U.S. Highway 231 over the Ohio River. The bridge connects Owensboro, Kentucky to Rockport, Indiana and opened on October 21, 2002. It is named in honor of William Huston Natcher, a former United States Representative who served Kentucky's 2nd Congressional District from 1954 until his death in 1994. The bridge project was named for Natcher only three months before his death. It is owned by the Commonwealth of Kentucky and was commissioned by the Kentucky Transportation Cabinet, in cooperation with the Indiana Department of Transportation and the Federal Highway Administration.
The Kennedy Interchange, unofficially, though universally, referred to as Spaghetti Junction, is the intersection of Interstate 64 (I-64), I-65 and I-71 at the northeastern edge of downtown Louisville, Kentucky, United States. It is named for the John F. Kennedy Memorial Bridge, which carries I-65, located immediately to the north of the interchange.
Interstate 470 (I-470) is a 10.63-mile-long (17.11 km) auxiliary Interstate Highway of I-70 that bypasses the city of Wheeling, West Virginia, United States. I-470 is one of 13 auxiliary Interstate Highways in Ohio and the only auxiliary Interstate Highway in West Virginia. The western terminus of I-470 is an interchange with I-70 in Richland Township, Ohio. Traveling southeast through rural Belmont County, I-470 approaches the Vietnam Veterans Memorial Bridge, which spans the Ohio River. After crossing the river into Ohio County, West Virginia, the highway continues east toward the Wheeling communities of Bethlehem and Elm Grove and its eastern terminus at I-70 near Elm Grove. The portion of the highway in West Virginia is named the USS West Virginia Memorial Highway by proclamation of then-Governor Cecil H. Underwood on the 59th anniversary of the attack on Pearl Harbor.
The U.S. Grant Bridge is the name of the two bridges that carry and have carried traffic on U.S. Route 23 between Portsmouth, Ohio and South Portsmouth, Kentucky across the Ohio River in the United States. The original suspension bridge was closed and demolished in 2001 and the replacement cable-stayed bridge opened on October 16, 2006.
State Route 852 is a north–south state highway in the southern portion of the U.S. state of Ohio. Its southern terminus is at the Kentucky state line on the Carl Perkins Memorial Bridge over the Ohio River near Portsmouth, and its northern terminus is at an interchange with the State Route 73/State Route 104 concurrency, just north of a complex interchange with U.S. Route 52 about 1.75 miles (2.82 km) west of Portsmouth.
U.S. Route 52 (US 52) skirts the western fringes of the U.S. state of West Virginia. It runs from the Virginia state line near Bluefield, where it is concurrent with Interstate 77 (I-77), in a general northwest and north direction to I-64 at Kenova. There it turns east, overlapping I-64 for five miles (8.0 km) before splitting off onto the West Huntington Expressway into Ohio via the West Huntington Bridge. Despite having an even number, US 52 is signed north–south in West Virginia. In some other states along its route, it is signed east-west. The West Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa. For a while, US 52 parallels US 23, which is on the other side of the Big Sandy River in Kentucky. This continues into Ohio, where US 52 travels on the Ohio side of the Ohio River while US 23 travels on the Kentucky side.
State Route 823 (SR 823), officially known as the Southern Ohio Veterans Memorial Highway and colloquially as the Portsmouth Bypass, is a north–south four-lane divided controlled-access highway in Scioto County, Ohio. The highway, which runs from Sciotodale to Lucasville, reroutes through traffic around the cities of Portsmouth and New Boston to the east. The bypass provides better mobility within the local area for residents and has the potential to increase the economic development of the local area. In September 2013, the Ohio Department of Transportation (ODOT) recommended a public–private partnership (P3) to fund and build the highway. Construction began in June 2015. The highway was dedicated on December 13, 2018 with vehicle traffic beginning the next day.
Interstate 90 (I-90) runs east–west across the northern tier of the US state of Ohio. Much of it is along the Ohio Turnpike, but sections outside the turnpike pass through Cleveland and northeast into Pennsylvania.
Interstate 69 (I-69), also known as the Iraq Afghanistan Veterans Memorial Highway south of Indianapolis, in the US state of Indiana travels southwest to northeast, connecting all 3 of the state's largest cities, Evansville, Indianapolis, and Fort Wayne. The highway proceeds north to the state of Michigan, reaching its capital city, Lansing and beyond, and is planned to eventually proceed south to the state of Kentucky and beyond.
Interstate 69 (I-69) in the U.S. state of Kentucky is a 148.1-mile-long (238.3 km) Interstate Highway running from the Tennessee state line in the southwest at Fulton to Henderson in the northeast, just south of the Ohio River. The route incorporates much of the former state parkway system, including the entire Purchase Parkway from Fulton to Calvert City, the western third of the Western Kentucky Parkway from Eddyville to Nortonville, and the northern half of the Pennyrile Parkway from Nortonville to Henderson. Between Calvert City and Eddyville, I-69 runs concurrently with I-24. Eventually, I-69 will leave the former Pennyrile Parkway just south of the Audubon Parkway interchange to bypass Henderson to the east before heading north into Indiana. The proposed route for the remainder of I-69 in Kentucky travels about 10 miles (16 km) before exiting on a bridge across the Ohio River to Indiana; construction on the first segment began in 2022, with completion scheduled in 2031.
Several special routes of U.S. Route 23 (US 23) exist. There are 18 extant special routes along US 23 and 14 former routes.
Interstate 65 (I-65) is part of the Interstate Highway System that runs 887.30 miles (1,427.97 km) north–south from Mobile, Alabama, to Gary, Indiana. The highway crosses Kentucky from south to north, from the Tennessee state line near Franklin to the Indiana state line in Louisville. I-65 passes through three of Kentucky's ten largest cities—Bowling Green, Elizabethtown, and Louisville—and serves Mammoth Cave National Park and Fort Knox. Kentucky was the first state to complete its portion of I-65, with the final section, located near Franklin, opening in 1970.
U.S. Route 23 (US 23) is a United States Numbered Highway that runs from Jacksonville, Florida, to Mackinaw City, Michigan. In the state of Ohio, it is a major north–south state highway that runs from the Kentucky border at Portsmouth to the Michigan border at Sylvania.
The Interstate 69 Ohio River Crossing is a planned bridge to carry the planned Interstate 69 (I-69) extension over the Ohio River between Evansville, Indiana, and Henderson, Kentucky. The bridge and its approach roadways make up a portion of Segment of Independent Utility 4 of the I-69 corridor from Michigan to Texas. It will be built approximately 1.62 miles (2.61 km) upstream of the existing Bi-State Vietnam Gold Star Bridges carrying U.S. Route 41 (US 41), at a point just downstream from where the Green River flows into the Ohio.
US 23 Truck / SR 852 
