Cartalax

Last updated

Cartalax
Cartalax structure.png
Identifiers
  • (2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]butanedioic acid
PubChem CID
Chemical and physical data
Formula C12H19N3O8
Molar mass 333.297 g·mol−1
3D model (JSmol)
  • C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)N
  • InChI=1S/C12H19N3O8/c1-5(13)10(20)14-6(2-3-8(16)17)11(21)15-7(12(22)23)4-9(18)19/h5-7H,2-4,13H2,1H3,(H,14,20)(H,15,21)(H,16,17)(H,18,19)(H,22,23)/t5-,6-,7-/m0/s1
  • Key:KXEVYGKATAMXJJ-ACZMJKKPSA-N

Cartalax (Ala-Glu-Asp, T-31, AED) is a tripeptide derivative developed in Russia. It has anti-aging effects in vitro and in animal models, and has been sold in Russian-speaking countries as well as more broadly over the internet as a supposed treatment for conditions such as arthritis, though only limited studies in humans have been published. [1] [2] [3] [4] [5] [6] [7]

See also

References

  1. ↑ Chalisova NI, Lin'kova NS, Nichik TE, Ryzhak AP, Dudkov AV, Ryzhak GA (May 2015). "Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals". Bulletin of Experimental Biology and Medicine. 159 (1): 124–127. doi:10.1007/s10517-015-2906-9. PMID   26033601.
  2. ↑ Lin'kova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, et al. (May 2016). "Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro". Bulletin of Experimental Biology and Medicine. 161 (1): 175–178. doi:10.1007/s10517-016-3370-x. PMID   27259496.
  3. ↑ Khavinson VK, Lin'kova NS, Tarnovskaya SI (December 2016). "Short Peptides Regulate Gene Expression". Bulletin of Experimental Biology and Medicine. 162 (2): 288–292. doi:10.1007/s10517-016-3596-7. PMID   27909961.
  4. ↑ Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N, et al. (2019). "Effect of short peptides on neuronal differentiation of stem cells". International Journal of Immunopathology and Pharmacology. 33 2058738419828613. doi:10.1177/2058738419828613. PMID   30791821.
  5. ↑ Zamorskii II, Shchudrova TS, Zeleniuk VG, Linkova NS, Nichik TE, Khavinson VK (2019). "The Influence of Peptides on the Morphofunctional State of Kidneys in Old Rats". Advances in Gerontology. 9: 75–80. doi:10.1134/S207905701901017X.
  6. ↑ Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B (June 2020). "Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides". Molecular Biology Reports. 47 (6): 4323–4329. doi:10.1007/s11033-020-05506-3. PMID   32399807.
  7. ↑ Khavinson V (2023). "Chapter 10: Results and future of peptides in clinical practice.". Handbook of Anti-Aging Medicine. ISBN   978-1-66293-020-1.
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