Cat pheromone

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A cat pheromone is a chemical molecule, or compound, that is used by cats and other felids for communication. [1] These pheromones are produced and detected specifically by the body systems of cats and evoke certain behavioural responses. [1] [2]

Contents

Cat pheromones are commonly released through the action of scent rubbing. [2] As such, one of the main proposed functions of pheromone release is to allow the cat to familiarize itself with its surroundings and other individuals, both in the newborn and adult stages of life. [3] [4] [5]

Specific cat pheromones that have been chemically identified include the feline facial pheromones F1-F5, the feline appeasing pheromone, and MMB in urine, most of which are associated with distinct feline behaviours. [2] [4] [6] Some of these chemical makeups have been synthetically reproduced and may be used by cat owners or veterinary professionals looking to change problematic or stress-induced behaviours. [7] [8]

Production and detection

The mechanism of chemical communication for felines involves chemical stimuli being secreted or excreted through the urine, faeces, saliva, or glands, with the stimuli being detected through vomeronasal or olfactory systems. [2] There are several scent glands located on felines that deposit pheromones when a cat rubs against an object. [3] This includes the cheek and perioral gland areas, which consist of several structures that secrete pheromones around the chin, cheeks, and lips. [4] Other scent glands for secreting the pheromones include the temporal glands on the sides of the forehead, the circumoral gland around the lips, sebaceous glands, perianal area, head, fingers, and toes. [3]

Cat pheromone detection is often accomplished through an action known as the flehmen response, where the cat lifts its head, slightly opens its mouth, pushes its tongue to the front of its palate, and retracts its upper lip. [7] [9]

A cat demonstrating a bunting behaviour on another cat. This would also be considered allorubbing between species. Two orange tabby cats greeting by rubbing-Hisashi-01.jpg
A cat demonstrating a bunting behaviour on another cat. This would also be considered allorubbing between species.

Pheromones are first released when a cat is born to establish the mother and kitten relationship. From this point on, the kitten uses the pheromones to establish relationships with other organisms and objects. The release of the pheromones in kittens is through the olfactory system, which is one of the systems that are fully developed at birth. [2] The olfactory chemical cues released by both the mother and the kitten may be used as reference points for newborns to create a relationship with their immediate environment. [8]

The importance of olfactory cues has been experimentally demonstrated in studies where kittens were removed from their nest. [3] [10] Those who were able to detect the pheromones returned to their nest quicker, and more often, than those who had lost their ability to detect the pheromones. This showed that pheromones help cats form a bond with their immediate environment.

Additionally, feline appeasing pheromones released by the mother while nursing may chemically enhance mother-kitten bonding and help maintain peace within the litter. [8] The feline appeasing pheromones are also called mother cat's pheromones, and are secreted in the mammary glands near her nipples. These pheromones help the kittens feel content and secure, and further helps the mother identify her kittens if they are separated from her. In short these pheromones are used to reduce tensions and conflict in cats. [11]

Past the newborn stage, chemical stimuli are commonly released through different forms of scent marking or scent rubbing. [2] Specific scent rubbing behaviours include bunting, in which an animal butts the front of its head against an object or individual, [12] and allorubbing, where two cats rub against each other. [13] Another scent rubbing behaviour that releases pheromones is social rolling, in which a cat flops over and rolls onto its backside to extend its body. [2] These types of pheromone releasers helps a cat to familiarize itself with a foreign area or individual, and diminish stress associated with being in a new or conflict-containing location. [3] [4] [5] When this behaviour occurs between two cats in a colony, it is likely an attempt to exchange scents and chemical stimuli such as pheromones. [13] It has been proposed that this behaviour of dispersing pheromones through scent rubbing also plays a role in visual communication, since the behaviour often coincides with a known individual coming near the cat. [4]

Feline facial and appeasing pheromones

There are five feline facial pheromones that have been identified from the chin, lip, and cheek sebaceous secretions; F1–F5. [2] [7] Although the chemical components have been identified for F1 and F5, their natural function and behavioural implications are not yet known. [4] As a whole, facial hormones F2–F4 assist with the marking of territories, however, they also have more specific individual functions. [4]

Composition of feline facial secretions (%) [14] [4]
fraction
substance
F1F2F3F4F5
oleic acid 34–4138–6262–8633–390
caproic acid 18–320000
trimethylamine 3–50002–6
5-aminovaleric acid 6–90009–15
n-butyric acid 5–150014–302–12
α-methylbutyric acid 6–90005–8
palmitic acid 017–4913–24028–37
propionic acid 011–23000
p-hydroxyphenylacetic acid 06–15008–19
azelaic acid 006–1307–17
pimelic acid 009–1211–240
5β-cholestan acid 3β-ol 00013–270
isobutyric acid 000011–18

F2

The feline facial pheromone F2 has been shown to be deposited during a mating behaviour conducted by males. [2] It is released as form of sexual marking, such that the male will rub its face on an object that is in proximity of a potential female partner. Releasing the F2 pheromone at the same time as its visible mating display may make the cat more effective at obtaining a mate. [3]

F3

Feline facial pheromone F3 is a chemical commonly released through object rubbing. [2] It is thought to be important in a cat’s ability to orient itself within its environment and know where it is in relation to its surroundings. [3] It is a territorial signal, in that cats mark the spaces they frequently use. [3] This may help to emotionally soothe the cat, such that being closer to the scent may increase a sense of security and belonging, while reducing anxiety. [2] [4]

F4

Also referred to as the "allomarking pheromone", [15] the feline facial pheromone F4's main associated behaviour is allomarking (or allorubbing). [3] This behaviour involves chemical stimuli being released through rubbing onto other cats in social settings. [13] It may also be deposited onto well-known humans in social situations. [3] The release of the F4 pheromone is suggested to be an indication that the individual being rubbed is familiar, and the cat will be less likely to instigate a conflict with them. [2]

Feline appeasing pheromone

In contrast to the facial pheromones, the feline appeasing pheromone is produced by the mammary sebaceous glands of a mother within the first few days of birthing a kitten. [16] Its release occurs through lactation and is linked with maternal bonding. [2] It is thought to play a role in attachment to the mother cat to ensure the kitten feels calm and protected, as well as serving the purpose of increasing harmonious interactions within the litter. [8]

The patent discloses the composition as a mixture of methyl palmitate, methyl linoleate, methyl oleate, methyl stearate, methyl laurate and methyl myristate. [17]

Synthetic pheromones and pheromonatherapy

Since the chemical compositions of natural pheromones have been isolated, this information can be used to construct synthetic solutions of these same compounds and activate a particular behavioural response. These analogous compounds can be used in the form of a diffuser or spray. [18] The use of these synthetic pheromones as a practical application to treat or alter animal behaviour is termed pheromone therapy or pheromonatherapy. [2] [18] The efficacy of pheromonatherapy is debated, and its effectiveness may depend on using the proper pheromone for the targeted behaviour in the right quantity. [4] Feline facial pheromones F3, F4, and the feline appeasing pheromone are three that have been artificially manufactured and have a proposed function to modify behaviour. [2] [4]

F3 synthetic analogue

The F3 pheromone was the first to be synthetically replicated. [3] Its attempted use is to reduce feline stress and associated behaviours such as excessive grooming, while instead promoting healthier behaviours of playing and eating. [3] [4] Recent research has investigated its effects on short-distance transport-related stress, and in a randomized pilot study, it was found that stress-related behaviours including curling, immobility, and meowing were reduced when using a synthetic F3 pheromone product compared to a placebo. [19] It can also be used to help eliminate urine spraying and scratching, which are undesirable scent-marking tendencies. [4] Concerning the problem behaviour related to scratching, a recent controlled study provided evidence of efficacy of this pheromone in reducing scratching behaviour. [20]

Some veterinary texts promote the placement of the F3 synthetic analogue in a location where the cat frequently visits and rests in, since the natural pheromone is thought to reduce distress based on proximity to the chemical. [2] It may also be sprayed onto the bed, cage, or towel of a cat in the veterinary consult room to diminish stress. [2]

F4 synthetic analogue

The F4 synthetic facial pheromone is sometimes used with poorly socialized cats to promote smoother interactions within animals of the same or different species. [4] It is suggested to work by misleading the cat into believing that a newcomer is someone they had previously encountered, therefore, inhibiting aggression and promoting acceptance of the stranger. [4] In a veterinary setting, the F4 pheromone may be rubbed on the professional to make handling easier and reduce escape tendencies for pets who have an immense fear of veterinarians. [15]

Feline appeasing pheromone synthetic analogue

Feline appeasing pheromone, with its route in maternal bonding, is made use of artificially in multi-cat households. When cats are first introduced or are experiencing conflicts, this pheromone may be diffused to alleviate stress and diminish socially tense behaviours, such as stalking and chasing. [8] In a recent pilot study looking at 45 multi-cat households who were experiencing cat conflicts, it was found that aggressive tendencies significantly decreased more in those who used a diffuser containing this pheromone as opposed to a placebo. [21]

Combination treatments

Other interventions, such as positive-reinforcement strategies or providing food puzzles as an enrichment source, may be used along with pheromone therapy to further reduce the incidence of problematic behaviours and promote emotional wellbeing. [2] [22] In addition, artificial pheromones may be used simultaneously with pharmacological treatment to increase the likelihood of a positive behavioural result, since they have different routes of action. [18] An example of a combination treatment looked at in the area of veterinary medicine is the use of the feline facial pheromone F3 analogue with clomipramine to treat between cat aggression and urine spraying. [18]

Cat urine odorants

Cat urine-like odorants
3-mercapto-3-methylbutan-1-ol.png
3-Mercapto-3-methylbutan-1-ol
4-methoxy-2-methylbutane-2-thiol.png
4-Methoxy-2-methylbutane-2-thiol
4-mercapto-4-methylpentan-2-one.png
4-Mercapto-4-methylpentan-2-one

Cat urine, especially that of male cats, contains the putative cat pheromone 3-mercapto-3-methylbutan-1-ol (MMB), a compound that gives cat urine its typical odor. The MMB precursor felinine is synthesized in the urine from 3-methylbutanol-cysteinylglycine (3-MBCG) by the excreted peptidase cauxin. Felinine then slowly degrades into the volatile MMB. [6]

Felinine chemical structure.svg → 3-mercapto-3-methylbutan-1-ol.svg
FelinineMMB

Rats and mice are highly averse to the odor of a cat's urine, but after infection with the parasite Toxoplasma gondii , they are attracted by it, greatly increasing the likelihood of being preyed upon and of infecting the cat. [23]

Cat attractants

A domestic cat demonstrating the effects of catnip such as rolling, pawing, and frisking Catnip-effects.jpg
A domestic cat demonstrating the effects of catnip such as rolling, pawing, and frisking

Although they are not produced by the cat themselves, and therefore are not pheromones, cat attractants are semiochemical odorants that have an effect on cat behavior and can be used for environmental enrichment. A cat presented with a cat attractant may roll in it, paw at it, or chew on the source of the smell. [24] The effect is usually relatively short, lasting for only a few minutes after which the cats have a refractory period during which the response cannot be elicited. After 30 minutes to two hours, susceptible cats gain interest again. About 1/3 of all cats are immune to its effects. [25]

Various volatile chemicals, iridoid terpenes extracted from essential oils, are known to cause these behavioral effects in cats. Cats are known to respond to catnip (Nepeta cataria), Tartarian honeysuckle (Lonicera tatarica), valerian (Valeriana officinalis), and silver vine (Actinidia polygama) to different degrees. [26] The active chemical for catnip and silver vine has been confirmed to be nepetalactone and nepetalactol respectively: they are found in the two plants and synthesized versions of these chemicals trigger similar responses in cats. [27] The active ingredient in Tartarian honeysuckle and valerian may be actinidine, but its effect is yet to be confirmed. [26]

Related Research Articles

<span class="mw-page-title-main">Cat</span> Small domesticated carnivorous mammal

The cat, commonly referred to as the domestic cat or house cat, is the only domesticated species in the family Felidae. Recent advances in archaeology and genetics have shown that the domestication of the cat occurred in the Near East around 7500 BC. It is commonly kept as a house pet and farm cat, but also ranges freely as a feral cat avoiding human contact. It is valued by humans for companionship and its ability to kill vermin. Because of its retractable claws, it is adapted to killing small prey like mice and rats. It has a strong, flexible body, quick reflexes, sharp teeth, and its night vision and sense of smell are well developed. It is a social species, but a solitary hunter and a crepuscular predator. Cat communication includes vocalizations like meowing, purring, trilling, hissing, growling, and grunting as well as cat body language. It can hear sounds too faint or too high in frequency for human ears, such as those made by small mammals. It also secretes and perceives pheromones.

<span class="mw-page-title-main">Pheromone</span> Secreted or excreted chemical factor that triggers a social response in members of the same species

A pheromone is a secreted or excreted chemical factor that triggers a social response in members of the same species. Pheromones are chemicals capable of acting like hormones outside the body of the secreting individual, to affect the behavior of the receiving individuals. There are alarm pheromones, food trail pheromones, sex pheromones, and many others that affect behavior or physiology. Pheromones are used by many organisms, from basic unicellular prokaryotes to complex multicellular eukaryotes. Their use among insects has been particularly well documented. In addition, some vertebrates, plants and ciliates communicate by using pheromones. The ecological functions and evolution of pheromones are a major topic of research in the field of chemical ecology.

<span class="mw-page-title-main">Nepetalactone</span> Chemical compound

Nepetalactone is a name for multiple iridoid analog stereoisomers. Nepetalactones are produced by Nepeta cataria (catnip) and many other plants belonging to the genus Nepeta, in which they protect these plants from herbivorous insects by functioning as insect repellents. They are also produced by many aphids, in which they are sex pheromones. Nepetalactones are cat attractants, and cause the behavioral effects that catnip induces in domestic cats. However, they affect visibly only about two thirds of adult cats. They produce similar behavioral effects in many other felids, especially in lions and jaguars. In 1941, the research group of Samuel M. McElvain was the first to determine the structures of nepetalactones and several related compounds.

<span class="mw-page-title-main">Vomeronasal organ</span> Smell sense organ above the roof of the mouth

The vomeronasal organ (VNO), or Jacobson's organ, is the paired auxiliary olfactory (smell) sense organ located in the soft tissue of the nasal septum, in the nasal cavity just above the roof of the mouth in various tetrapods. The name is derived from the fact that it lies adjacent to the unpaired vomer bone in the nasal septum. It is present and functional in all snakes and lizards, and in many mammals, including cats, dogs, cattle, pigs, and some primates. Some humans may have physical remnants of a VNO, but it is vestigial and non-functional.

<span class="mw-page-title-main">Dog communication</span> Communication of dogs with other dogs and as well as humans

Dog communication is the transfer of information between dogs, as well as between dogs and humans. Behaviors associated with dog communication are categorized into visual and vocal. Visual communication includes mouth shape and head position, licking and sniffing, ear and tail positioning, eye gaze, facial expression, and body posture. Dog vocalizations, or auditory communication, can include barks, growls, howls, whines and whimpers, screams, pants and sighs. Dogs also communicate via gustatory communication, utilizing scent and pheromones.

<span class="mw-page-title-main">Scent gland</span> Exocrine glands found in most mammals

Scent gland are exocrine glands found in most mammals. They produce semi-viscous secretions which contain pheromones and other semiochemical compounds. These odor-messengers indicate information such as status, territorial marking, mood, and sexual behaviour. The odor may be subliminal—not consciously detectable. Though it is not their primary function, the salivary glands may also function as scent glands in some animals.

<span class="mw-page-title-main">Feline lower urinary tract disease</span> Any disorder affecting the bladder or urethra of cats

Feline lower urinary tract disease (FLUTD) is a generic category term to describe any disorder affecting the bladder or urethra of cats.

<span class="mw-page-title-main">Cat communication</span> Feline means of sending or receiving information

Cats need to communicate for a variety of reasons, including to show happiness, to express anger, to solicit attention, and to observe potential prey; cats collaborate, play, and share resources with each other. When they communicate with humans, they do so to get what they need or want, such as food, water, attention, or play.

<span class="mw-page-title-main">Cat behavior</span> Behavior of cats

Cat behavior is a cat's behavior and responses to events and other stimuli. Cat behavior includes body language, elimination habits, aggression, play, communication, hunting, grooming, urine marking, and face rubbing. It varies among individuals, colonies, and breeds.

<span class="mw-page-title-main">3-Mercapto-3-methylbutan-1-ol</span> Chemical compound

3-Mercapto-3-methylbutan-1-ol, also known as MMB, is a common odorant found in food and cat urine. The aromas ascribed to MMB include catty, roasty, broth-like, meaty, and savory, or similar to cooked leeks.

Cauxin is a carboxylesterase that is excreted in large amounts in cat urine. There is also evidence that it can serve as a peptide hydrolase in the production of cat pheromone precursors. Cauxin has a mass of 70 kilodaltons and is composed of 545 amino acids. The protein can also exist as a multimeric protein complex connected by disulfide bonds with a mass of 300-350 kilodaltons. This is its primary form in non-reducing conditions. The proximal tubules of epithelial cells in the kidney express cauxin. This protein is secreted into the urine from the renal tubular cells. The gene for the protein is also found in several other mammalian genomes in various organs. However, the only mammals that have cauxin present in urine are cats. It is also the first carboxylesterase to be found in urine.

<span class="mw-page-title-main">Catnip</span> Nepeta cataria; species of plant

Nepeta cataria, commonly known as catnip, catswort, catwort, and catmint, is a species of the genus Nepeta in the family Lamiaceae, native to southern and eastern Europe, the Middle East, Central Asia, and parts of China. It is widely naturalized in northern Europe, New Zealand, and North America. The common name catmint can also refer to the genus as a whole.

Feline idiopathic cystitis (FIC) or feline interstitial cystitis or cystitis in cats, is one of the most frequently observed forms of feline lower urinary tract disease (FLUTD). Feline cystitis means "inflammation of the bladder in cats". The term idiopathic means unknown cause; however, certain behaviours have been known to aggravate the illness once it has been initiated. It can affect both males and females of any breed of cat. It is more commonly found in female cats; however, when males do exhibit cystitis, it is usually more dangerous.

<span class="mw-page-title-main">Cat training</span> Modifying a cats behavior

Cat training is the process of modifying a domestic cat's behavior for entertainment or companionship purposes. Training is commonly used to reduce unwanted or problematic behaviors in domestic cats, to enhance interactions between humans and pet cats, and to allow them to coexist comfortably. There are various methods for training cats which employ different balances between reward and punishment.

<span class="mw-page-title-main">Exotic Feline Rescue Center</span>

The Exotic Feline Rescue Center (EFRC) is an American exotic feline preserve established in 1991 and located in Center Point, Indiana.

<span class="mw-page-title-main">Major urinary proteins</span> Proteins found in the urine and other secretions of many animals

Major urinary proteins (Mups), also known as α2u-globulins, are a subfamily of proteins found in abundance in the urine and other secretions of many animals. Mups provide a small range of identifying information about the donor animal, when detected by the vomeronasal organ of the receiving animal. They belong to a larger family of proteins known as lipocalins. Mups are encoded by a cluster of genes, located adjacent to each other on a single stretch of DNA, that varies greatly in number between species: from at least 21 functional genes in mice to none in humans. Mup proteins form a characteristic glove shape, encompassing a ligand-binding pocket that accommodates specific small organic chemicals.

<span class="mw-page-title-main">Dog appeasing pheromone</span>

Dog appeasing pheromone (DAP), sometimes known as apasine, is a mixture of esters of fatty acids released by the sebaceous glands in the inter-mammary sulcus of lactating female dogs. It is secreted from between three and four days after parturition and two to five days after weaning. DAP is believed to be detected by the vomeronasal organ and has an appeasing effect on both adults and pups, and assists in establishing a bond with the mother.

<span class="mw-page-title-main">Bunting (animal behavior)</span>

Bunting is a form of animal behavior, often found in cats, in which the animal butts or rubs its head against other things, including people. Bunting as a behaviour can be viewed as a variation of scent rubbing. This is when an animal, typically a carnivore, will rub its back on a scent, such as that of prey, or on the urine of an animal of the same species. Evolutionarily speaking, scent rubbing is the oldest form of scent communication and bunting is a derivative of this behaviour. Rolling in the scent of another animal was an adaptation to camouflage the scent of a predator or outside male, in order to get closer to mates.

<span class="mw-page-title-main">Scent rubbing</span> Behaviour where a mammal rubs its body against an object in their environment

Scent rubbing is a behavior where a mammal rubs its body against an object in their environment, sometimes in ones covered with strongly odored substances. It is typically shown in carnivores, although many mammals exhibit this behavior. Lowering shoulders, collapsing the forelegs, pushing forward and rubbing the chin, temples, neck, or back is how this act is performed. A variety of different odors can elicit this behavior including feces, vomit, fresh or decaying meat, insecticide, urine, repellent, ashes, human food and so on. Scent rubbing can be produced by an animal smelling novel odors, which include manufactured smells such as perfume or motor oil and carnivore smells including feces and food smells.

References

  1. 1 2 Wyatt TD (October 2010). "Pheromones and signature mixtures: defining species-wide signals and variable cues for identity in both invertebrates and vertebrates". Journal of Comparative Physiology A. 196 (10): 685–700. doi:10.1007/s00359-010-0564-y. PMID   20680632. S2CID   16824968.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Vitale KR (November 2018). "Tools for Managing Feline Problem Behaviors: Pheromone therapy". Journal of Feline Medicine and Surgery. 20 (11): 1024–1032. doi:10.1177/1098612x18806759. PMID   30375946. S2CID   53115782.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 Shreve KR, Udell MA (2017). "Stress, security, and scent: The influence of chemical signals on the social lives of domestic cats and implications for applied settings". Applied Animal Behaviour Science. 187: 69–76. doi: 10.1016/j.applanim.2016.11.011 . ISSN   0168-1591.
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Pageat P, Gaultier E (March 2003). "Current research in canine and feline pheromones". The Veterinary Clinics of North America. Small Animal Practice. 33 (2): 187–211. doi:10.1016/s0195-5616(02)00128-6. PMID   12701508.
  5. 1 2 Weiss E, Mohan-Gibbons H, Zawistowski S (2015). Animal behavior for shelter veterinarians and staff. Ames, Iowa. ISBN   978-1-119-42131-3. OCLC   905600053.{{cite book}}: CS1 maint: location missing publisher (link)
  6. 1 2 Miyazaki M, Yamashita T, Suzuki Y, Saito Y, Soeta S, Taira H, Suzuki A (October 2006). "A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor". Chemistry & Biology. 13 (10): 1071–1079. doi: 10.1016/j.chembiol.2006.08.013 . PMID   17052611.
  7. 1 2 3 Hewson C (2014). "Evidence-based approaches to reducing in-patient stress – Part 2: Synthetic pheromone preparations". Veterinary Nursing Journal. 29 (6): 204–206. doi: 10.1111/vnj.12140 . ISSN   1741-5349. S2CID   85015744.
  8. 1 2 3 4 5 Hargrave C (April 2021). "Pheromones and 25 years of pheromonotherapy: what are they and how do they work?". The Veterinary Nurse. 12 (3): 116–122. doi:10.12968/vetn.2021.12.3.116. ISSN   2044-0065. S2CID   238042295.
  9. ↑ Tirindelli R, Dibattista M, Pifferi S, Menini A (July 2009). "From pheromones to behavior". Physiological Reviews. 89 (3): 921–956. doi:10.1152/physrev.00037.2008. hdl: 11566/296739 . PMID   19584317.
  10. ↑ Mermet N, Coureaud G, McGrane S, Schaal B (September 2007). "Odour-guided social behaviour in newborn and young cats: an analytical survey". Chemoecology. 17 (4): 187–199. doi:10.1007/s00049-007-0384-x. ISSN   1423-0445. S2CID   21280703.
  11. ↑ What are Cat Pheromones
  12. ↑ Englar RE (2017). Performing the small animal physical examination. Hoboken, NJ. ISBN   978-1-119-29532-7. OCLC   989520169.{{cite book}}: CS1 maint: location missing publisher (link)
  13. 1 2 3 Crowell-Davis SL, Curtis TM, Knowles RJ (February 2004). "Social organization in the cat: a modern understanding". Journal of Feline Medicine and Surgery. 6 (1): 19–28. doi:10.1016/j.jfms.2003.09.013. PMID   15123163. S2CID   25719922.
  14. ↑ Pageat, Patrick (20 January 1998). "US5709863A Properties of cats' facial pheromones". Google Patents.
  15. 1 2 Pageat P, Tessier Y (1997). "F4 Synthetic Pheromone: A Means To Enable Handling of Cats With A Phobia Of The Veterinarian During Consultation" (PDF). AGRIS Records, Food and Agriculture Organisation of the United Nations. Archived (PDF) from the original on 2020-05-30. Retrieved 2021-10-24.
  16. ↑ DePorter TL (January 2016). "Chapter 18 – Use of Pheromones in Feline Practice". In Rodan I, Heath S (eds.). Feline Behavioral Health and Welfare. St. Louis: W.B. Saunders. pp. 235–244. doi:10.1016/b978-1-4557-7401-2.00018-0. ISBN   978-1455774012.
  17. ↑ Pageat, Patrick (25 January 2017). "Cat appeasing pheromone".
  18. 1 2 3 4 Mills D (2005). "Pheromonatherapy: theory and applications". In Practice. 27 (7): 368–373. doi:10.1136/inpract.27.7.368. ISSN   0263-841X. S2CID   73157933.
  19. ↑ Shu H, Gu X (September 2021). "Effect of a synthetic feline facial pheromone product on stress during transport in domestic cats: a randomised controlled pilot study". Journal of Feline Medicine and Surgery. 24 (8): 691–699. doi:10.1177/1098612x211041305. PMID   34493099. S2CID   237440871.
  20. ↑ Pereira Soares, Joana; Demirbas Salgirli, Yasemin; Meppiel, Laurianne; Endersby, Sarah; Pereira da Graça, Gonçalo; De Jaeger, Xavier (18 October 2023). "Efficacy of the Feliway Classic Diffuser in reducing undesirable scratching in cats: A randomised, triple-blind, placebo-controlled study". PLoS One. 18 (10): e0292188. doi: 10.1371/journal.pone.0292188 . ISSN   1932-6203. PMC   10584138 .
  21. ↑ DePorter TL, Bledsoe DL, Beck A, Ollivier E (April 2019). "Evaluation of the efficacy of an appeasing pheromone diffuser product vs placebo for management of feline aggression in multi-cat households: a pilot study". Journal of Feline Medicine and Surgery. 21 (4): 293–305. doi:10.1177/1098612X18774437. PMC   6435919 . PMID   29757071.
  22. ↑ Dantas LM, Delgado MM, Johnson I, Buffington CT (September 2016). "Food puzzles for cats: Feeding for physical and emotional wellbeing". Journal of Feline Medicine and Surgery. 18 (9): 723–732. doi: 10.1177/1098612x16643753 . PMID   27102691. S2CID   27014669.
  23. ↑ Berdoy M, Webster JP, Macdonald DW (August 2000). "Fatal attraction in rats infected with Toxoplasma gondii". Proceedings. Biological Sciences. 267 (1452): 1591–1594. doi:10.1098/rspb.2000.1182. PMC   1690701 . PMID   11007336.
  24. ↑ Grognet J (June 1990). "Catnip: Its uses and effects, past and present". The Canadian Veterinary Journal. 31 (6): 455–456. PMC   1480656 . PMID   17423611.
  25. ↑ "How does catnip work its magic on cats?". Scientific American. May 29, 2007. Retrieved 25 July 2014.
  26. 1 2 Bol S, Caspers J, Buckingham L, Anderson-Shelton GD, Ridgway C, Buffington CA, et al. (March 2017). "Responsiveness of cats (Felidae) to silver vine (Actinidia polygama), Tatarian honeysuckle (Lonicera tatarica), valerian (Valeriana officinalis) and catnip (Nepeta cataria)". BMC Veterinary Research. 13 (1): 70. doi: 10.1186/s12917-017-0987-6 . PMC   5356310 . PMID   28302120.
  27. ↑ Uenoyama R, Miyazaki T, Hurst JL, Beynon RJ, Adachi M, Murooka T, et al. (January 2021). "The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes". Science Advances. 7 (4): eabd9135. Bibcode:2021SciA....7.9135U. doi: 10.1126/sciadv.abd9135 . PMC   7817105 . PMID   33523929. S2CID   231681044.
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