Cdc42 effector protein 5

CDC42EP5
Identifiers
Aliases	CDC42EP5 , Borg3, CEP5, CDC42 effector protein 5
External IDs	OMIM: 609171; MGI: 1929745; HomoloGene: 10984; GeneCards: CDC42EP5; OMA:CDC42EP5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,473,296 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,167,859 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; olfactory zone of nasal mucosa; ; prostate; ; rectum; ; ascending aorta; ; tibial nerve; ; Descending thoracic aorta; ; canal of the cervix; ; Achilles tendon;
	Top expressed in
	intestinal villus; ; duodenum; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; mucous cell of stomach; ; large intestine; ; pyloric antrum; ; colon; ; crypt of lieberkuhn of small intestine; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity ;
Cellular component	cytosol ; cytoskeleton ; endomembrane system ; membrane ; plasma membrane ; cytoplasm ;
Biological process	JNK cascade ; positive regulation of pseudopodium assembly ; positive regulation of actin filament polymerization ; regulation of cell shape ; positive regulation of GTPase activity ; Rho protein signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	148170
	58804
	ENSG00000167617
	ENSMUSG00000063838
	Q6NZY7
	Q9Z0X0
	NM_145057
	NM_021454
	NP_659494
	NP_067429
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 15, 2024

CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. ^[5]

Function

Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].

Related Research Articles

FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome. Orthologs of the FGD1 gene are found in dog, cow, mouse, rat, and zebrafish, and also budding yeast and C. elegans. It is a member of the FYVE, RhoGEF and PH domain containing family.

G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.

Dishevelled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.

FYVE, RhoGEF and PH domain-containing protein 4 is a protein encoded in humans by the FGD4 gene.

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

Dedicator of cytokinesis protein 6 (Dock6), also known as Zir1 is a large protein encoded in the human by the DOCK6 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G-proteins.

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.

Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene.

Active breakpoint cluster region-related protein is a protein that in humans is encoded by the ABR gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167617 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063838 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CDC42 effector protein 5" . Retrieved 2018-04-25.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167617 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDC42 effector protein 5" . Retrieved 2018-04-25.

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