Cdc42 effector protein 5

CDC42EP5
Identifiers
Aliases	CDC42EP5 , Borg3, CEP5, CDC42 effector protein 5
External IDs	OMIM: 609171 MGI: 1929745 HomoloGene: 10984 GeneCards: CDC42EP5
Gene location (Human)
Chr.	Chromosome 19 (human) [1]
End	54,473,296 bp [1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse) [2]
End	4,164,860 bp [2]
Gene ontology
Molecular function	• GTP-Rho binding ; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity ;
Cellular component	• cytosol ; • cytoskeleton ; • endomembrane system ; • membrane ; • cell membrane ; • cytoplasm ;
Biological process	• JNK cascade ; • positive regulation of pseudopodium assembly ; • positive regulation of actin filament polymerization ; • regulation of cell shape ; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity ; • Rho protein signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	148170
	58804
	ENSG00000167617 ; ENSG00000273633 ; ENSG00000278444 ; ENSG00000273622
	ENSMUSG00000063838
	Q6NZY7
	Q9Z0X0
	NM_145057
	NM_021454
	NP_659494
	NP_067429
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 24, 2020

CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. ^[5]

Function

Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].

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References

1 2 3 ENSG00000273633, ENSG00000278444, ENSG00000273622 GRCh38: Ensembl release 89: ENSG00000167617, ENSG00000273633, ENSG00000278444, ENSG00000273622 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063838 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CDC42 effector protein 5" . Retrieved 2018-04-25.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000273633, ENSG00000278444, ENSG00000273622 GRCh38: Ensembl release 89: ENSG00000167617, ENSG00000273633, ENSG00000278444, ENSG00000273622 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063838 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDC42 effector protein 5" . Retrieved 2018-04-25.