CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. [5]
Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].
Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.
G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.
Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.
Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.
Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.
Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.
Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.
Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.
FYVE, RhoGEF and PH domain-containing protein 4 is a protein that in humans is encoded by the FGD4 gene.
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.
Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.
The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.
Rho GTPase activating protein 21 is a protein that in humans is encoded by the ARHGAP21 gene.
CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene.
ABR, RhoGEF and GTPase activating protein is a protein that in humans is encoded by the ABR gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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