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Established | 2010 |
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Director | Robert Cross |
Faculty | 21 |
Address | Gibbet Hill Road, Coventry CV4 7AL |
Location | , |
Coordinates | 52°22′25.98″N1°33′8.07″W / 52.3738833°N 1.5522417°W |
Website | mechanochemistry |
The Centre for Mechanochemical Cell Biology (CMCB) is a research centre at the University of Warwick, specialising in quantitative, biophysical approaches to cell biology. [1] The Centre was founded by Robert Cross, Andrew McAinsh and Anne Straube when they relocated from the Marie Curie Research Institute in Oxted, Surrey, UK to Warwick Medical School. [2] It has expanded to become an inter-disciplinary centre with research groups led by principal investigators from Physics, Computer Science, Maths and Warwick Medical School.
Research groups in the centre focus on themes such as cell division, cytoskeleton, molecular motors and membrane traffic. They are supported by Wellcome Trust, Cancer Research UK, Medical Research Council (United Kingdom) and Biotechnology and Biological Sciences Research Council. Notable scientists in CMCB [3] include Andrew McAinsh (2018 Hooke Medal Winner [4] [5] ), Stephen Royle (2021 Hooke Medal Winner) and Anne Straube (Lister Institute Prize Fellow). [6] Many of the groups are located in the Mechanochemical Cell Biology Building [7] on the Gibbet Hill Campus. The building was opened in April 2012 by Nobel Prize laureate Paul Nurse. An extension to the building was subsequently built and opened by Nobel Prize winning cell biologist Randy Schekman in 2016.
During the COVID-19 pandemic, the virtual seminar series "Motors in Quarantine" was initiated by CMCB scientists led by Prof. Anne Straube. [8]
As of 2023 [update] there are 21 Group Leaders in the Centre. [9]
Group Leaders:
Günter Blobel was a Silesian German and American biologist and 1999 Nobel Prize laureate in Physiology for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell.
George Emil Palade was a Romanian-American cell biologist. Described as "the most influential cell biologist ever", in 1974 he was awarded the Nobel Prize in Physiology and Medicine along with Albert Claude and Christian de Duve. The prize was granted for his innovations in electron microscopy and cell fractionation which together laid the foundations of modern molecular cell biology, the most notable discovery being the ribosomes of the endoplasmic reticulum – which he first described in 1955.
The Stanford University School of Medicine is the medical school of Stanford University and is located in Stanford, California, United States. It traces its roots to the Medical Department of the University of the Pacific, founded in San Francisco in 1858. This medical institution, then called Cooper Medical College, was acquired by Stanford in 1908. The medical school moved to the Stanford campus near Palo Alto, California, in 1959.
Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM is an American biologist whose research on the nematode worm Caenorhabditis elegans, was awarded the 2002 Nobel Prize in Physiology or Medicine, together with Sydney Brenner and John E. Sulston, whose "seminal discoveries concerning the genetic regulation of organ development and programmed cell death" were "important for medical research and have shed new light on the pathogenesis of many diseases".
WEHI, previously known as the Walter and Eliza Hall Institute of Medical Research, and as the Walter and Eliza Hall Institute, is Australia's oldest medical research institute. Sir Frank Macfarlane Burnet, who won the Nobel Prize in 1960 for his work in immunology, was director from 1944 to 1965. Burnet developed the ideas of clonal selection and acquired immune tolerance. Later, Professor Donald Metcalf discovered and characterised colony-stimulating factors. As of 2015, the institute hosted more than 750 researchers who work to understand, prevent and treat diseases including blood, breast and ovarian cancers; inflammatory diseases (autoimmunity) such as rheumatoid arthritis, type 1 diabetes and coeliac disease; and infectious diseases such as malaria, HIV and hepatitis B and C.
Joseph Leonard Goldstein ForMemRS is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs.
Eric Francis Wieschaus is an American evolutionary developmental biologist and 1995 Nobel Prize-winner.
Mario Ramberg Capecchi is an Italian-born molecular geneticist and a co-awardee of the 2007 Nobel Prize in Physiology or Medicine for discovering a method to create mice in which a specific gene is turned off, known as knockout mice. He shared the prize with Martin Evans and Oliver Smithies. He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine.
Sir Paul Maxime Nurse is an English geneticist, former President of the Royal Society and Chief Executive and Director of the Francis Crick Institute. He was awarded the 2001 Nobel Prize in Physiology or Medicine, along with Leland Hartwell and Tim Hunt, for their discoveries of protein molecules that control the division of cells in the cell cycle.
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health.
The Cancer Research UK London Research Institute (LRI) was a biological research facility which conducted research into the basic biology of cancer.
Frances Rosemary Balkwill is an English scientist, Professor of Cancer Biology at Queen Mary University of London, and author of children's books about scientific topics.
Ada E. Yonath is an Israeli crystallographer and Nobel laureate in Chemistry, best known for her pioneering work on the structure of ribosomes. She is the current director of the Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly of the Weizmann Institute of Science.
Emmanuelle Marie Charpentier is a French professor and researcher in microbiology, genetics, and biochemistry. As of 2015, she has been a director at the Max Planck Institute for Infection Biology in Berlin. In 2018, she founded an independent research institute, the Max Planck Unit for the Science of Pathogens. In 2020, Charpentier and American biochemist Jennifer Doudna of the University of California, Berkeley, were awarded the Nobel Prize in Chemistry "for the development of a method for genome editing". This was the first science Nobel Prize ever won by two women only.
Vivian Li is a Hong Kong-born cell and developmental biologist working in cancer research at London's Francis Crick Institute. She has been researching how stem cells in the human bowel are programmed to ensure a healthy organ and what goes wrong when cancer develops. She is known for her work on the Wnt signalling pathway, discovering a new way that a molecule called Wnt is activated in bowel cancer. She won a Future Leaders in Cancer Research Prize in part for this discovery.
Anne Bertolotti is a French biochemist and cell biologist who works as Programme Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK. In 2022 she was appointed Head of the MRC LMB's Neurobiology Division. She is known for her research into the cellular defences against misfolded proteins and the mechanisms underlying their deposition, the molecular problem causative of neurodegenerative diseases.
Victoria Sanz Moreno is a Spanish scientist. She is professor of cancer cell and metastasis biology at The Institute of Cancer Research.
Maria do Carmo Fonseca is a Portuguese scientist, full professor of Molecular Cell Biology and Onco-biology at the University of Lisbon Medical School and president of the Instituto de Medicina Molecular João Lobo Antunes.
Yanlan Mao is a British biologist who is a professor at University College London. Her research considers cell biology and the molecular mechanisms that underpin tissue formation. She was awarded the Royal Microscopical Society Medal for Life Sciences in 2021.