Randy Schekman

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Randy Schekman
Randy Shekman 01.JPG
Schekman in 2015
Born
Randy Wayne Schekman

(1948-12-30) December 30, 1948 (age 75)
Saint Paul, Minnesota, U.S.
Alma mater University of California, Los Angeles (BA)
Stanford University (PhD)
Known forEditor-in-chief of PNAS [1] and eLife [2]
Awards
Scientific career
Institutions University of California, Berkeley
UCLA
Howard Hughes Medical Institute
Stanford University
Thesis Resolution and reconstruction of a multienzyme DNA replication reaction  (1975)
Doctoral advisor Arthur Kornberg
Doctoral students David Julius [5]
David Baker
Website mcb.berkeley.edu/labs/schekman
royalsociety.org/people/randy-schekman

Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley, [6] former editor-in-chief of Proceedings of the National Academy of Sciences and former editor of Annual Review of Cell and Developmental Biology . [1] [7] [8] [9] In 2011, he was announced as the editor of eLife , a new high-profile open-access journal published by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust launching in 2012. [10] He was elected to the National Academy of Sciences in 1992. [11] Schekman shared the 2013 Nobel Prize for Physiology or Medicine with James Rothman and Thomas C. Südhof for their ground-breaking work on cell membrane vesicle trafficking. [12] [13]

Contents

Early life and education

Schekman was born in Saint Paul, Minnesota, to Alfred Schekman, an electrical engineer and computer software designer and Esther (Bader) Schekman. [14] His family were Jewish emigrants from Russia and Bessarabia. [15] In the late 1950s his family moved to the new suburban community of Rossmoor, located in Orange County next to Long Beach. He graduated from Western High School in Anaheim, California, in 1966. [16] He received a BA in molecular biology from the University of California, Los Angeles (UCLA), in 1971. He spent his third year at the University of Edinburgh in Scotland, as an exchange student. [1] [17] He received a PhD in 1975 from Stanford University for research on DNA replication working with Arthur Kornberg. [18] After joining the faculty at University of California Berkeley, he was promoted to associate professor in 1981 and Professor in 1984.

Research and career

Since 1991, Schekman has been a Howard Hughes Medical Institute Investigator, [19] division of biochemistry and molecular biology, department of molecular and cell biology, at the University of California, Berkeley. The Schekman Lab at that university carries out research into molecular descriptions of the process of membrane assembly and vesicular traffic [20] in eukaryotic cells [21] [22] including yeast. [23] Before that, he was a faculty member with the now disbanded Department of Biochemistry at the same university.

Awards and honors

In 1987 Schekman received the Eli Lilly Award in Microbiology. In 1992, Schekman was elected a Member of the National Academy of Sciences. [24] In 2002, Schekman received the Albert Lasker Award for Basic Medical Research [25] and Louisa Gross Horwitz Prize of Columbia University along with James Rothman for their discovery of cellular membrane trafficking, a process that cells use to organize their activities and communicate with their environment. [26] In 2008 he was named the first Miller Senior Fellow of the Miller Institute at the University of California Berkeley. That same year, he was elected to the American Philosophical Society. [27] He was awarded the Massry Prize from the Keck School of Medicine, University of Southern California, in 2010. Schekman serves as a member of the Selection Committee and then as chair of Life Science and Medicine which chooses winners of the Shaw Prize.

Schekman was elected a Foreign Member of the Royal Society (ForMemRS) in 2013. His nomination reads:

Using a brilliantly conceived genetic screen, Schekman isolated sec mutants that accumulate secretory pathway intermediates, he cloned the corresponding genes and he established biochemical reactions that faithfully reproduced specific secretory pathway events. These studies transformed the secretion field, previously descriptive and morphological, into a molecular and mechanistic one. The cell-free reactions that Schekman established led to his isolation of the Sec61 translocation complex, the (COPII) vesicle coat complex, and the first purified inter-organelle transport vesicles. The Sec proteins are strikingly conserved and the trafficking mechanisms that Schekman discovered are at the heart of neurotransmission, hormone secretion, cholesterol homeostasis and metabolic regulation. [3]

Schekman, Thomas C. Südhof, and James Rothman were awarded the 2013 Nobel Prize for Physiology or Medicine "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells". [12] Schekman donated his share of the prize money, $400,000, to create an endowment for the Esther and Wendy Schekman Chair in Basic Cancer Biology at UC Berkeley. Schekman's mother and sister, for whom the post is named, both died of cancer. [28]

In 2017, Schekman received the Golden Plate Award of the American Academy of Achievement. [29]

In 2021, Professor Randy Schekman was elected honorary member of the Academy of Sciences of Moldova, with which he has been collaborating since 2019. [30]

In 2023, he was awarded the title of Doctor Honoris Causa at Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova. [31] [32]

Open-access science

In December 2013, Schekman called for academic journal publishing reform and open access science publication by announcing that his lab at the University of California, Berkeley would no longer submit to the prestigious closed-access journals Nature , Cell , and Science , citing their self-serving and deleterious effects on science. [33] He has criticized these journals for artificially restricting the number of publications accepted to drive up demand. [33] In addition, Schekman says the journals accept papers that will be cited often, increasing the prestige of the journal, rather than those which demonstrate important results. [33] Schekman has said the prestige and difficulty of publishing in these journals sometimes cause scientists to cut corners or pursue trends, rather than conduct research on important questions. Schekman is the former editor of eLife , an open access journal and competitor to Nature, Cell, and Science. [33] Papers are accepted into eLife based on review by working scientists. [33] Access to accepted papers is free. [33]

Parkinson's Disease

In the fall of 2017, Schekman's wife, Nancy Walls, died after a 20-year struggle with Parkinson's disease. Near the end of this difficult period Schekman was enlisted to serve as the scientific director of a new effort called ASAP aimed at organizing an international program of collaborative research on the origins and mechanisms of progression of Parkin's Disease. In cooperation with The Michael J. Fox Foundation and major philanthropic support, ASAP has grown by 2022 to involve 35 teams across 165 laboratories around the world. The goal of ASAP is bridge the talents of hundreds of scientists to develop novel insights leading to more effective treatments of this disease.

See also

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References

  1. 1 2 3 Zagorski, N. (2008). "Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief". Proceedings of the National Academy of Sciences. 105 (8): 2763–2765. Bibcode:2008PNAS..105.2763Z. doi: 10.1073/pnas.0610781105 . PMC   2268533 . PMID   18287009.
  2. ↑ Schekman, R.; Patterson, M. (2013). "Reforming research assessment". eLife. 2: e00855. doi: 10.7554/eLife.00855 . PMC   3656620 . PMID   23700504.
  3. 1 2 "Professor Randy Schekman ForMemRS". Royalsociety.org. Retrieved October 7, 2013.
  4. ↑ Wickner, W. T. (2013). "Profile of Thomas Sudhof, James Rothman, and Randy Schekman, 2013 Nobel Laureates in Physiology or Medicine". Proceedings of the National Academy of Sciences. 110 (46): 18349–50. Bibcode:2013PNAS..11018349W. doi: 10.1073/pnas.1319309110 . PMC   3832004 . PMID   24158482.
  5. ↑ "Julius Lab - David Julius". Physio.ucsf.edu. Retrieved October 7, 2013.
  6. ↑ "Randy Schekman: Howard Hughes Investigator and Professor of Cell and Developmental Biology" . Retrieved July 12, 2011.
  7. ↑ Bucci, M. (2006). "Randy Schekman". Nature Chemical Biology. 2 (11): 568. doi: 10.1038/nchembio1106-568 . PMID   17051227. S2CID   40321085.
  8. ↑ Zagorski, N. (2006). "QnAs with Randy Schekman". Proceedings of the National Academy of Sciences. 103 (50): 18881. Bibcode:2006PNAS..10318881Z. doi: 10.1073/pnas.0609700103 . PMC   1748144 . PMID   17148596.
  9. ↑ Schekman, Randy (1999). "Preface by Randy Schekman". Annual Review of Cell and Developmental Biology. 15. doi:10.1146/annurev.cb.15.010199.100001.
  10. ↑ "New journal editor named as Randy Schekman | Wellcome Trust". Archived from the original on October 11, 2013. Retrieved July 12, 2011.
  11. ↑ Randy Schekman publications indexed by Microsoft Academic
  12. 1 2 "The Nobel Prize in Physiology or Medicine 2013". Nobel Foundation. Retrieved October 7, 2013.
  13. ↑ Randy Schekman's publications indexed by the Scopus bibliographic database. (subscription required)
  14. ↑ "'Not a prank': St. Paul native lands 2013 Nobel Prize in Medicine". Star Tribune.
  15. ↑ "The Nobel Prize in Physiology or Medicine 2013".
  16. ↑ Marroquin, Art (October 19, 2013). "Nobel Prize winner credits high school teacher". Orange County Register . p. Local 7.
  17. ↑ "Randy Schekman, molecular biologist and UCLA alumnus, wins 2013 Nobel Prize". University of California, Los Angeles. Retrieved October 8, 2013.
  18. ↑ Schekman, Randy Wayne (1975). Resolution and Reconstruction of a multienzyme DNA replication reaction (1975) (PhD thesis). Stanford University. ProQuest   302775556.
  19. ↑ "HHMI Scientist Abstract: Randy W. Schekman, Ph.D." Retrieved July 12, 2011.
  20. ↑ Schekman, R.; Orci, L. (1996). "Coat Proteins and Vesicle Budding". Science. 271 (5255): 1526–1533. Bibcode:1996Sci...271.1526S. doi:10.1126/science.271.5255.1526. PMID   8599108. S2CID   30752342.
  21. ↑ "Randy Schekman publications in Google Scholar" . Retrieved July 12, 2011.
  22. ↑ Deshaies, R. J.; Koch, B. D.; Werner-Washburne, M.; Craig, E. A.; Schekman, R. (1988). "A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides". Nature. 332 (6167): 800–805. Bibcode:1988Natur.332..800D. doi:10.1038/332800a0. PMID   3282178. S2CID   39993735.
  23. ↑ Novick, P.; Field, C.; Schekman, R. (1980). "Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway". Cell. 21 (1): 205–215. doi: 10.1016/0092-8674(80)90128-2 . PMID   6996832.
  24. ↑ "Randy W. Schekman". www.nasonline.org.
  25. ↑ Malhotra, V.; Emr, S. D. (2002). "Rothman and Schekman SNAREd by Lasker for trafficking". Cell. 111 (1): 1–3. doi: 10.1016/S0092-8674(02)01008-5 . PMID   12372293. S2CID   16018931.
  26. ↑ "Louisa Gross Horwitz Prize Awardees" . Retrieved October 13, 2013.
  27. ↑ "APS Member History". search.amphilsoc.org. Retrieved May 3, 2021.
  28. ↑ "US biologist Randy Schekman on being a Nobel Prize winner". Financial Times. November 8, 2013. Retrieved January 10, 2014.
  29. ↑ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  30. ↑ MoldovaLive (September 19, 2023). "Nobel Laureate Randy Schekman Visits Moldova, Celebrates its Roots, and Academic Collaboration". Moldova. Retrieved November 28, 2023.
  31. ↑ "Professor Randy Schekman, Nobel Prize Laureate in Medicine, has become Doctor Honoris Causa of "Nicolae Testemitanu" State University of Medicine and Pharmacy". usmf.md. Retrieved November 28, 2023.
  32. ↑ "PHOTO USMF". www.moldpres.md. Retrieved November 28, 2023.
  33. 1 2 3 4 5 6 Sample, Ian (December 9, 2013). "Nobel winner declares boycott of top science journals". theguardian.com. Retrieved December 16, 2013.
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