Konrad Emil Bloch was a German-American biochemist. Bloch received the Nobel Prize in Physiology or Medicine in 1964 for discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism.
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation or for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor.
Vitamin deficiency is the condition of a long-term lack of a vitamin. When caused by not enough vitamin intake it is classified as a primary deficiency, whereas when due to an underlying disorder such as malabsorption it is called a secondary deficiency. An underlying disorder can have 2 main causes:
Edward Calvin Kendall was an American biochemist. In 1950, Kendall was awarded the Nobel Prize for Physiology or Medicine along with Swiss chemist Tadeusz Reichstein and Mayo Clinic physician Philip S. Hench, for their work with the hormones of the adrenal glands. Kendall not only researched the adrenal glands, he also isolated thyroxine, a hormone of the thyroid gland and worked with the team that crystallized glutathione and identified its chemical structure.
William Parry Murphy Sr. was an American physician who shared the Nobel Prize in Physiology or Medicine in 1934 with George Richards Minot and George Hoyt Whipple for their combined work in devising and treating macrocytic anemia.
Fritz Albert Lipmann was a German-American biochemist and a co-discoverer in 1945 of coenzyme A. For this, together with other research on coenzyme A, he was awarded the Nobel Prize in Physiology or Medicine in 1953.
Bengt Ingemar Samuelsson was a Swedish biochemist. He shared with Sune K. Bergström and John R. Vane the 1982 Nobel Prize for Physiology or Medicine for discoveries concerning prostaglandins and related substances.
Sir Frederick Gowland Hopkins was an English biochemist who was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins. He also discovered the amino acid tryptophan, in 1901. He was President of the Royal Society from 1930 to 1935.
Stanley Cohen was an American biochemist who, along with Rita Levi-Montalcini, was awarded the Nobel Prize in Physiology or Medicine in 1986 for the isolation of nerve growth factor and the discovery of epidermal growth factor. He died in February 2020 at the age of 97.
Feodor Felix Konrad Lynen was a German biochemist. In 1964 he won the Nobel Prize in Physiology or Medicine together with Konrad Bloch for their discoveries concerning the mechanism and regulation of cholesterol and fatty acid metabolism while he was director of the Max-Planck Institute for Cellular Chemistry in Munich.
Werner Arber is a Swiss microbiologist and geneticist. Along with American researchers Hamilton Smith and Daniel Nathans, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction endonucleases. Their work would lead to the development of recombinant DNA technology.
Joseph Erlanger was an American physiologist who is best known for his contributions to the field of neuroscience. Together with Herbert Spencer Gasser, he identified several varieties of nerve fiber and established the relationship between action potential velocity and fiber diameter. They were awarded the Nobel Prize in Physiology or Medicine in 1944 for these achievements.
George Wald was an American scientist and activist who studied pigments in the retina. He won a share of the 1967 Nobel Prize in Physiology or Medicine with Haldan Keffer Hartline and Ragnar Granit.
Arthur Kornberg was an American biochemist who won the Nobel Prize in Physiology or Medicine 1959 for the discovery of "the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid" together with Spanish biochemist and physician Severo Ochoa of New York University. He was also awarded the Paul-Lewis Award in Enzyme Chemistry from the American Chemical Society in 1951, an L.H.D. degree from Yeshiva University in 1962, and the National Medal of Science in 1979. In 1991, Kornberg received the Golden Plate Award of the American Academy of Achievement and the Gairdner Foundation Award in 1995.
Joseph Leonard Goldstein ForMemRS is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs.
Edmond Henri Fischer was a Swiss-American biochemist. He and his collaborator Edwin G. Krebs were awarded the Nobel Prize in Physiology or Medicine in 1992 for describing how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes. From 2007 until 2014, he was the Honorary President of the World Cultural Council. At the time of his death at age 101 in 2021, he was the oldest living Nobel Prize laureate.
Edward Adelbert Doisy was an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1943 with Henrik Dam for their discovery of vitamin K and its chemical structure.
Louis Frederick Fieser was an American organic chemist, professor, and in 1968, professor emeritus at Harvard University. His award-winning research included work on blood-clotting agents including the first synthesis of vitamin K, synthesis and screening of quinones as antimalarial drugs, work with steroids leading to the synthesis of cortisone, and study of the nature of polycyclic aromatic hydrocarbons. He also invented militarily effective napalm while at Harvard in 1942.
The University of Rochester Medical Center (URMC), now known as UR Medicine, is located in Rochester, New York, is a medical complex on the main campus of the University of Rochester and comprises the university's primary medical education, research and patient care facilities.
