Elizabeth Blackburn

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Elizabeth Blackburn

Elizabeth Blackburn CHF Heritage Day 2012 Rush 001.JPG
With AIC Gold Medal, 2012
Born
Elizabeth Helen Blackburn

(1948-11-26) 26 November 1948 (age 70)
Hobart, Tasmania, Australia
ResidenceUS
CitizenshipAustralian and American
Alma mater
Awards
Scientific career
FieldsMolecular biology
Institutions
Thesis Sequence studies on bacteriophage ØX174 DNA by transcription  (1974)
Doctoral advisor Frederick Sanger [1]
Doctoral students Carol W. Greider
Website biochemistry2.ucsf.edu/labs/blackburn

Elizabeth Helen Blackburn, AC FRS FAA FRSN [2] (born 26 November 1948) is an Australian-American Nobel laureate who is the former President of the Salk Institute for Biological Studies. [3] Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For this work, she was awarded the 2009 Nobel Prize in Physiology or Medicine, sharing it with Greider and Jack W. Szostak, becoming the only Tasmanian-born Nobel laureate. She also worked in medical ethics, and was controversially dismissed from the Bush Administration's President's Council on Bioethics. [4]

Fellow of the Royal Society Elected Fellow of the Royal Society, including Honorary, Foreign and Royal Fellows

Fellowship of the UK Royal Society is an award granted to individuals that the Royal Society of London judges to have made a 'substantial contribution to the improvement of natural knowledge, including mathematics, engineering science, and medical science'.

Australia Country in Oceania

Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania, and numerous smaller islands. It is the largest country in Oceania and the world's sixth-largest country by total area. The neighbouring countries are Papua New Guinea, Indonesia, and East Timor to the north; the Solomon Islands and Vanuatu to the north-east; and New Zealand to the south-east. The population of 25 million is highly urbanised and heavily concentrated on the eastern seaboard. Australia's capital is Canberra, and its largest city is Sydney. The country's other major metropolitan areas are Melbourne, Brisbane, Perth, and Adelaide.

United States Federal republic in North America

The United States of America (USA), commonly known as the United States or America, is a country comprising 50 states, a federal district, five major self-governing territories, and various possessions. At 3.8 million square miles, the United States is the world's third or fourth largest country by total area and is slightly smaller than the entire continent of Europe's 3.9 million square miles. With a population of over 327 million people, the U.S. is the third most populous country. The capital is Washington, D.C., and the most populous city is New York City. Forty-eight states and the capital's federal district are contiguous in North America between Canada and Mexico. The State of Alaska is in the northwest corner of North America, bordered by Canada to the east and across the Bering Strait from Russia to the west. The State of Hawaii is an archipelago in the mid-Pacific Ocean. The U.S. territories are scattered about the Pacific Ocean and the Caribbean Sea, stretching across nine official time zones. The extremely diverse geography, climate, and wildlife of the United States make it one of the world's 17 megadiverse countries.

Contents

Early life and education

International Day of Women and Girls in Science Blackburn USE.png
International Day of Women and Girls in Science

Elizabeth Helen Blackburn was born in Hobart, Tasmania on 26 November 1948 to parents who were both family physicians. [5] Her family moved to the city of Launceston when she was four, where she attended the Broadland House Church of England Girls' Grammar School (later amalgamated with Launceston Church Grammar School) until the age of sixteen. Upon her family's relocation to Melbourne, she attended University High School, and ultimately gained very high marks in the end-of-year final statewide matriculation exams. [6] She went on to earn a Bachelor of Science in 1970 and Master of Science in 1972, both from the University of Melbourne in the field of biochemistry. Blackburn then went to receive her PhD in 1975 from the University of Cambridge, where she worked with Frederick Sanger developing methods to sequence DNA using RNA, as well studied the bacteriophage Phi X 174. [5] It was also here, the Medical Research Council (MRC) Laboratory of Molecular Biology at Cambridge University, where Blackburn met her husband John Sedat. [7] Blackburn's soon to be husband had taken a position at Yale, where she then decided to finish her postdoctoral. [5] “Thus it was that love brought me to a most fortunate and influential choice: Joe Gall’s lab at Yale.”

Hobart City in Tasmania, Australia

Hobart is the capital and most populous city of the Australian island state of Tasmania. With a population of approximately 225,000, it is the least populated Australian state capital city, and second smallest if territories are taken into account. Founded in 1804 as a British penal colony, Hobart, formerly known as Hobart Town or Hobarton, is Australia's second oldest capital city after Sydney, New South Wales. Prior to British settlement, the Hobart area had been occupied for possibly as long as 35,000 years, by the semi-nomadic Mouheneener tribe, a sub-group of the Nuennone, or South-East tribe. The descendants of these Aboriginal Tasmanians often refer to themselves as 'Palawa'.

Tasmania island state of Australia

Tasmania is an island state of Australia. It is located 240 km (150 mi) to the south of the Australian mainland, separated by Bass Strait. The state encompasses the main island of Tasmania, the 26th-largest island in the world, and the surrounding 334 islands. The state has a population of around 526,700 as of March 2018. Just over forty percent of the population resides in the Greater Hobart precinct, which forms the metropolitan area of the state capital and largest city, Hobart.

Launceston, Tasmania City in Tasmania, Australia

Launceston is a city in the north of Tasmania, Australia, at the junction of the North Esk and South Esk rivers where they become the Tamar River (Kanamaluka). Launceston is the second largest city in Tasmania after Hobart and the thirteenth-largest non-capital city in Australia.

Career and research

During her postdoctoral work at Yale, Blackburn was doing research on the protozoan Tetrahymena thermophila and noticed a repeating codon at the end of the linear rDNA which varied in size. [8] Blackburn then noticed that this hexanucleotide at the end of the chromosome contained a TTGGGG sequence that was tandomly repeated, and the terminal end of the chromosomes were palindromic. These characteristics allowed Blackburn and colleagues to conduct further research on the protozoan. Using the telomeric repeated end of Tetrahymena, Blackburn and colleague Jack Szostak showed the unstable replicating plasmids of yeast were protected from degradation, proving that these sequences contained characteristics of telomeres. [8] This research also proved the telomeric repeats of Tetrahymena were conserved evolutionarily between the species. [8] Through this research, Blackburn and collaborators noticed the replication system for chromosomes was not likely to add to the lengthening of the telomere, and that the addition of these hexanucleotides to the chromosomes was likely due to the activity of an enzyme that is able to transfer specific functional groups. [8] The proposition of a possible transferase-like enzyme lead Blackburn and PhD student Carol W. Greider to the discovery of an enzyme with reverse transcriptase activity that was able to fill in the terminal ends of telomeres without leaving the chromosome incomplete and unable to divide without loss of the end of the chromosome. [9] This 1985 discovery lead to the purification of this enzyme in lab, showing the transferase-like enzyme contained both RNA and protein components. [8] The RNA portion of the enzyme served as a template for adding the telomeric repeats to the incomplete telomere, and the protein added enzymatic function for the addition of these repeats.Through this breakthrough, the term “telomerase” was given to the enzyme, solving the end-replication process that had troubled scientists at the time. [9]

Tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other. Several protein domains also form tandem repeats within their amino acid primary structure, such as armadillo repeats. However, in proteins, perfect tandem repeats are unlikely in most in vivo proteins, and most known repeats are in proteins which have been designed.

Telomerase

Telomerase works by adding base pairs to the overhang of DNA on the 3’ end, extending the strand until DNA polymerase and an RNA primer can complete the complementary strand and successfully synthesize the double stranded DNA. Since DNA polymerase only synthesizes DNA in the leading strand direction, the shortening of the telomere results. [10] Through their research, Blackburn and collaborators were able to show that the telomere is effectively replenished by the enzyme telomerase, which conserves cellular division by preventing the rapid loss of genetic information internal to the telomere, leading to cellular aging. [8]

Telomerase telomerase

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of eukaryotic chromosomes in most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly Drosophila melanogaster lacks telomerase, but instead uses retrotransposons to maintain telomeres.

          

On January 1, 2016, Blackburn was interviewed about her studies, discovering telomerase, and her current research. When she was asked to recall the moment of telomerase discovery she stated: [11]

Carol had done this experiment, and we stood, just in the lab, and I remember sort of standing there, and she had this – we call it a gel. It's an autoradiogram because there were trace amounts of radioactivity that were used to develop an image of the separated DNA products of what turned out to be the telomerase enzyme reaction. I remember looking at it and just thinking, 'Ah! This could be very big. This looks just right.' It had a pattern to it. There was a regularity to it. There was something that was not just sort of garbage there, and that was really kind of coming through, even though we look back at it now, we'd say, technically, there was this, that and the other, but it was a pattern shining through, and it just had this sort of sense, 'Ah! There's something real here.' But then, of course, the good scientist has to be very sceptical and immediately say, 'Okay, we're going to test this every way around here, and really nail this one way or the other.' If it's going to be true, you have to make sure that it's true, because you can get a lot of false leads, especially if you're wanting something to work. [11]

In 1978, Blackburn joined the faculty of the University of California, Berkeley, in the Department of Molecular Biology. In 1990, she moved across the San Francisco Bay to the Department of Microbiology and Immunology at the University of California, San Francisco (UCSF), where she served as the Department Chair from 1993 to 1999 and was the Morris Herzstein Professor of Biology and Physiology at UCSF. Blackburn became a Professor Emeritus at UCSF at the end of 2015. [12] [13]

Blackburn, co-founded the company Telomere Health which offers telomere length testing to the public, but later severed ties with the company. [14] [15]

In 2015, Elizabeth Blackburn was announced as the new President of the Salk Institute for Biological Studies in La Jolla, California. “Few scientists garner the kind of admiration and respect that Dr. Blackburn receives from her peers for her scientific accomplishments and her leadership, service and integrity,” says Irwin M. Jacobs, chairman of Salk's Board of Trustees, on Blackburn's appointment as President of the Institute. “Her deep insight as a scientist, her vision as a leader, and her warm personality will prove invaluable as she guides the Salk Institute on its continuing journey of discovery.”  In 2017, she announced her plans to retire from the Salk Institute the following year. [16]

Nobel Prize

For their research and contributions to the understanding of telomeres and the enzyme telomerase, Elizabeth Blackburn, Carol Greider, and Jack Szostaks were awarded the 2009 Nobel Prize in Physiology or Medicine.The substantial research on the effects of chromosomal protection from telomerase, and the impact this has on cellular division has been a revolutionary catalyst in the field of molecular biology. [17] For example, the addition of telomerase to cells that do not possess this enzyme has shown to bypass the limit of cellular aging in those cells, thereby linking this enzyme to reduced cellular aging. [17] The addition of telomerase, and the presence of the enzyme in cancer cells has been shown to provide an immunity mechanism for the cell in proliferating, linking the transferase activity to increased cellular growth and reduced sensitivity for cellular signalling. The importance of discovering this enzyme has since sent lead her continued research at the University of California San Franscisco, where she studies the effect of telomeres and telomerase activity on cellular aging. [18]

Bioethics

Blackburn was appointed a member of the President's Council on Bioethics in 2002. [19] She supported human embryonic cell research, in opposition to the Bush Administration. Her Council terms were terminated by White House directive on 27 February 2004. [20] Dr. Blackburn believes that she was dismissed from the Council due to her disapproval of the Bush administration's position against stem cell research. [21] This was followed by expressions of outrage over her removal by many scientists, who maintained that she was fired because of political opposition to her advice.[ citation needed ]

Scientists and ethicists at the time even went as far to say that Blackburn's removal was in violation of Federal Advisory Committee Act of 1972, which “requires balance on such advisory bodies” [21]

"There is a growing sense that scientific research—which, after all, is defined by the quest for truth—is being manipulated for political ends," wrote Blackburn. "There is evidence that such manipulation is being achieved through the stacking of the membership of advisory bodies and through the delay and misrepresentation of their reports." [22] [23]

Blackburn serves on the Science Advisory Board of the Regenerative Medicine Foundation formerly known as the Genetics Policy Institute. [24]

Publications

Blackburn's first book The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer [25] (2017) was co-authored with health psychologist Dr. Elissa Epel of Aging, Metabolism, and Emotions (AME) Center at the UCSF Center for Health and Community. [26] Blackburn comments on aging reversal and care for one's telomeres through lifestyle: managing chronic stress, exercising, eating better and getting enough sleep; telomere testing, plus cautions and advice. [27] While studying telomeres and the replenishing enzyme, telomerase, Blackburn discovered a vital role played by these protective caps that revolved around one central idea: aging of cells. The book hones in on many of the effects that poor health can have on telomeres and telomerase activity. [28] Since telomeres shorten with every division of a cell, replenishing these caps is essential to long term cell growth. Through research and data, Blackburn explained that people that lead stressful lives exhibit less telomerase functioning in the body, which leads to a decrease in the dividing capabilities of the cell. [28] Once telomeres shorten drastically, the cells can no longer divide, meaning the tissues they replenish with every division would therefore die out, highlighting the aging mechanism in humans. To increase telomerase activity in people with stress-filled lives, Blackburn suggests moderate exercise, even 15 minutes a day, which has been proven to stimulate telomerase activity and replenish the telomere. [28]

Blackburn also states that unhappiness in lives also has an effect on the shortening of telomeres. In a study done on divorced couples, their telomere length was "significantly shorter" compared to couples in healthy relationships, and Blackburn states, "There's an obvious stressor... we are intensely social beings." [29] She suggests to include positivity into our daily lives to increase health as well. While increasing the amount of exercise, decreasing stress, tobacco use, and maintaining a balanced sleep schedule, Blackburn explains that our telomeres can be drastically maintained and prevented from rapid shortening, leading to a decrease in the aging process of our cells. [29] Blackburn also tells the readers to be wary of clinical pills who proclaim to lengthen or telomeres and protect the body from aging. She says that these pills and creams have no scientific proof of being anti-aging supplements, and that the key to preserving our telomeres and stimulating telomerase activity comes from leading a healthy life. [29]

Current research

In recent years Blackburn and her colleagues have been investigating the effect of stress on telomerase and telomeres [30] with particular emphasis on mindfulness meditation. [31] [32] She is also one of several biologists (and one of two Nobel Prize laureates) in the 1995 science documentary Death by Design/The Life and Times of Life and Times . Studies suggest that chronic psychological stress may accelerate ageing at the cellular level. Intimate partner violence was found to shorten telomere length in formerly abused women versus never abused women, possibly causing poorer overall health and greater morbidity in abused women. [33]

At the University of California San Francisco, Blackburn currently researches telomeres and telomerase many organisms, from yeast to human cells. [18] The lab is focused on telomere maintenance, and how this has an impact on cellular aging. Many chronic diseases have been associated with the improper maintenance of these telomeres, thereby effecting cellular division, cycling, and impaired growth. At the cutting edge of telomere research, the Blackburn lab currently investigates the impact of limited maintenance of telomeres in cells through altering the enzyme telomerase. [18]

Awards and Honors

Blackburns awards and honors include:

Elizabeth Blackburn (Nobel Prize in Medicine or Physiology 2009) in Stockholm, June 2016 Elizabeth Blackburn (Nobel Medicine or Physiology 2009) in Stockholm, June 2016.jpg
Elizabeth Blackburn (Nobel Prize in Medicine or Physiology 2009) in Stockholm, June 2016

Blackburn was elected:

In 2007, Blackburn was listed among Time Magazine's The TIME 100 – The People Who Shape Our World. [47]

Personal life

Blackburn splits her time living between La Jolla and San Francisco with her husband, scientist John W. Sedat, and has a son, Benjamin. [48] In her personal life, Blackburn serves as a mentor and advocate for scientific research and policy, influencing generations to come to continue the research and work that she has initiated. [49]

Related Research Articles

Physiology science of the function of living systems

Physiology is the scientific study of the functions and mechanisms which work within a living system.

Nobel Prize in Physiology or Medicine One of five Nobel Prizes established in 1895 by Alfred Nobel

The Nobel Prize in Physiology or Medicine, administered by the Nobel Foundation, is awarded yearly for outstanding discoveries in the fields of life sciences and medicine. It is one of five Nobel Prizes established in his will in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite. Nobel was interested in experimental physiology and wanted to establish a prize for scientific progress through laboratory discoveries. The Nobel Prize is presented at an annual ceremony on 10 December, the anniversary of Nobel's death, along with a diploma and a certificate for the monetary award. The front side of the medal displays the same profile of Alfred Nobel depicted on the medals for Physics, Chemistry, and Literature. The reverse side is unique to this medal. The most recent Nobel prize was announced by Karolinska Institute on 1 October 2018, and has been awarded to American James P. Allison and Japanese Tasuku Honjo – for their discovery of cancer therapy by inhibition of negative immune regulation.

Telomere nucleotide sequences

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes. Its name is derived from the Greek nouns telos (τέλος) "end" and merοs "part". For vertebrates, the sequence of nucleotides in telomeres is AGGGTT, with the complementary DNA strand being TCCCAA, with a single-stranded TTAGGG overhang. This sequence of TTAGGG is repeated approximately 2,500 times in humans. In humans, average telomere length declines from about 11 kilobases at birth to fewer than 4 kilobases in old age, with the average rate of decline being greater in men than in women.

The year 1984 in science and technology involved some significant events.

Thomas Cech Nobel laureate in chemistry

Thomas Robert Cech is an American chemist who shared the 1989 Nobel Prize in Chemistry with Sidney Altman, for their discovery of the catalytic properties of RNA. Cech discovered that RNA could itself cut strands of RNA, suggesting that life might have started as RNA. He also studied telomeres, and his lab discovered an enzyme, TERT, which is part of the process of restoring telomeres after they are shortened during cell division. As president of Howard Hughes Medical Institute, he promoted science education, and he teaches an undergraduate chemistry course at the University of Colorado.

The Hayflick limit or Hayflick phenomenon is the number of times a normal human cell population will divide before cell division stops.

Michael D. West American businessman

Michael D. West is a gerontologist, and a pioneer in stem cells, cellular aging and telomerase. He is the founder and CEO of AgeX Therapeutics, a startup focused on the field of interventional gerontology, and Co-CEO of its parent company, BioTime, Inc. of Alameda, California, a biotechnology company regarded as a leader in the field of regenerative medicine with a focus on cell therapy.

Joseph Grafton Gall is an American cell biologist who is noted for studies revealing the details of chromosome structure and function. Gall's studies were greatly facilitated by his knowledge of many different organisms because he could select the most favorable organism to study when approaching a specific question about nuclear structure. He was awarded the 2006 Albert Lasker Special Achievement Award. He was also a co-recipient of the 2007 Louisa Gross Horwitz Prize from Columbia University. In 1983 he was honored with the highest recognition of the American Society for Cell Biology, the E. B. Wilson Medal. He had been elected to the National Academy of Sciences in 1972.

The Heineken Prizes for Arts and Sciences consist of eleven awards biannually bestowed by Royal Netherlands Academy of Arts and Sciences (KNAW). The prizes are named in honor of Henry Pierre Heineken, son of founder Gerard Adriaan Heineken, Alfred Heineken, former chairman of Heineken Holdings and Charlene de Carvalho-Heineken, current chair of the Heineken Prizes Foundations which fund all Heineken Prizes for Arts and Sciences. Thirteen winners of the Dr H. P. Heineken Prize for Biochemistry and Biophysics or the Dr A. H. Heineken Prize for Medicine have gone on to win a Nobel Prize.

Carol W. Greider molecular biologist

Carolyn Widney "Carol" Greider is an American molecular biologist and Nobel laureate. She is a Bloomberg Distinguished Professor, Daniel Nathans Professor, and Director of Molecular Biology and Genetics at Johns Hopkins University. She discovered the enzyme telomerase in 1984, while she was a graduate student of Elizabeth Blackburn at the University of California, Berkeley. Greider pioneered research on the structure of telomeres, the ends of the chromosomes. She was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Blackburn and Jack W. Szostak, for their discovery that telomeres are protected from progressive shortening by the enzyme telomerase.

Pearl Meister Greengard Prize women scientist award

The Pearl Meister Greengard Prize is an award for women scientists in biology given annually by the Rockefeller University.

The United States-Israel Binational Science Foundation (BSF) is a grant-awarding institution that promotes collaborative research in a wide range of basic and applied scientific disciplines, established in 1972 by an agreement between the governments of the United States and Israel. Numerous scientists participating in BSF programs have won prestigious awards such as the Nobel, Lasker and Wolf prizes. The Foundation grant recipients include 43 Nobel Prize laureates, 19 winners of the Lasker-DeBakey Clinical Medical Research Award, and 38 recipients of the Wolf Prize.

Jack W. Szostak American biologist

Jack William Szostak is a Canadian American biologist of Polish British descent, Nobel Prize laureate, Professor of Genetics at Harvard Medical School, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston. Szostak has made significant contributions to the field of genetics. His achievement helped scientists to map the location of genes in mammals and to develop techniques for manipulating genes. His research findings in this area are also instrumental to the Human Genome Project. He was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Elizabeth Blackburn and Carol W. Greider, for the discovery of how chromosomes are protected by telomeres.

Alexey Matveyevich Olovnikov is a Russian biologist. In 1971, he was the first to recognize the problem of telomere shortening, to predict the existence of telomerase, and to suggest the telomere hypothesis of aging and the relationship of telomeres to cancer He was not awarded a share of the 2009 Nobel Prize in Physiology or Medicine, awarded for the discovery of the enzyme and its biological significance. In 2009 he was awarded Demidov Prize of the Russian Academy of Sciences.

Titia de Lange Dutch geneticist

Titia de Lange is the Director of the Anderson Center for Cancer Research, the Leon Hess professor and the head of Laboratory Cell Biology and Genetics at Rockefeller University.

This is a timeline of women in science in the United States.

María Blasco Marhuenda Spanish scientist

María Antonia Blasco Marhuenda, known as María Blasco, is a Spanish molecular biologist. She is the current director of the Spanish National Centre for Cancer Research.

Bryant Villeponteau is an American scientist, entrepreneur, and longevity expert who has worked in both academia and industry. His early work included the cloning of the RNA component of human telomerase when working at Geron Corporation, which led to his winning the 1997 Distinguished Inventor Award for cloning human telomerase along with three of his Geron teammates. In 2008, Villeponteau went on to serve as Vice President of Research of the aging genetics company Genescient, Inc., which uses machine learning technologies, biochemistry, and Drosophila genetics to develop therapeutics to help delay the aging process. He is also a cofounder of Centagen, Inc., which focuses on developing new technologies for extending human health and longevity by promoting adult stem cells.

Victoria Lundblad is an American geneticist whose work focuses on the genetic control of chromosome behavior in yeast. Many of her discoveries have concerned telomerase, the RNA-containing enzyme that completes the ends of chromosomes. She is located at the Salk Institute in La Jolla, CA.

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