Andrew Wilkie | |
|---|---|
| Born | Andrew Oliver Mungo Wilkie 14 September 1959 [1] |
| Education | Arnold House School Westminster School |
| Alma mater | |
| Awards | EMBO Member (2006) [2] |
| Scientific career | |
| Fields | Medical genetics |
| Institutions | University of Oxford |
| Notable students | Anne Goriely (postdoc) [3] |
| Website | www |
Andrew Oliver Mungo Wilkie (born 14 September 1959) [1] FRS FMedSci FRCP [4] is a clinical geneticist who has been the Nuffield professor of Pathology at the University of Oxford since 2003. [4] [5] [6] [7]
Wilkie was educated at Arnold House School, Westminster School and Trinity College, Cambridge, where he was awarded a Bachelor of Arts degree in 1980 and a Master of Arts degree in 1984. [1] He moved to Merton College, Oxford, where he was awarded a Bachelor of Medicine, Bachelor of Surgery degree in 1983 and subsequently a Doctor of Medicine degree in 1992. [1]
Wilkie's research investigates genetic disorders affecting the skull and limbs, especially craniosynostosis [8] – premature fusion of the sutures of the skull. He identified the gene mutation responsible for Apert syndrome and the molecular pathways underlying this and other craniosynostosis conditions. These results have led to many clinical diagnostic tests. [4] [9]
Wilkie's discovery that the mutation causing Apert syndrome was more common than expected led him to develop the 'selfish selection' theory, which states that there is a proliferation or survival advantage for some mutations in the testis. Over time, sperm-generating cells carrying such mutations become prevalent, explaining why some conditions are more common in children born to older fathers. [4]
Wilkie demonstrated that the Ras molecular pathway, the common factor in paternal age effect conditions, is also important in the development of nerves and tumours. Consequently, his work has implications for other diseases, including autism and cancer. [4] His research has been funded by the Medical Research Council (MRC). [10] His former postdoctoral students include Anne Goriely. [3]
Wilkie was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2002, [11] the European Molecular Biology Organization (EMBO) in 2006 [2] and a Fellow of the Royal Society (FRS) in 2013. [4]
Sir John Ernest Walker is a British chemist who won the Nobel Prize in Chemistry in 1997. As of 2015 Walker is Emeritus Director and Professor at the MRC Mitochondrial Biology Unit in Cambridge, and a Fellow of Sidney Sussex College, Cambridge.
Dame Kay Elizabeth Davies is a British geneticist. She is Dr Lee's Professor of Anatomy at the University of Oxford and a Fellow of Hertford College, Oxford. She is director of the Medical Research Council (MRC) functional genetics unit, a governor of the Wellcome Trust, a director of the Oxford Centre for Gene Function, and a patron and Senior Member of Oxford University Scientific Society. Her research group has an international reputation for work on Duchenne muscular dystrophy (DMD). In the 1980s, she developed a test which allowed for the screening of foetuses whose mothers have a high risk of carrying DMD.
Sir John Anthony Hardy is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.
Sir John Stewart Savill, FRS, FMedSci is the Chief Executive of the Medical Research Council (MRC) in the UK and the Head of the College of Medicine and Veterinary Medicine and a Vice Principal of the University of Edinburgh.
Mariann Bienz, Lady Pelham FRS FMedSci is a Swiss-British molecular biologist based at the UK Medical Research Council Laboratory of Molecular Biology. She has been a member of their Senior Scientific Staff since 1991, was Joint-head of Cell Biology in 2007-08 and has been a Group Leader of Protein and Nucleic Acid Chemistry Division since 2008.
Laurence Daniel Hurst is a Professor of Evolutionary Genetics in the Department of Biology and Biochemistry at the University of Bath and the director of the Milner Centre for Evolution.
Hugh Christian Watkins is a British cardiologist. He is a Fellow of Merton College, Oxford, an associate editor of Circulation Research, and was Field Marshal Alexander Professor of Cardiovascular Medicine in the University of Oxford between 1996 and 2013.
Steve David Macleod Brown is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire, a research centre on mouse genetics. In addition, he leads the Genetics and Pathobiology of Deafness research group.
Jonathon Noë Joseph Pines is Head of the Cancer Biology Division at the Institute of Cancer Research in London. He was formerly a senior group leader at the Gurdon Institute at the University of Cambridge.
(Edith) Yvonne Jones is director of the Cancer Research UK Receptor Structure Research Group at the University of Oxford and a Fellow of Jesus College, Oxford. She is widely known for her research on the molecular biology of cell surface receptors and signalling complexes.
Anne Jacqueline Ridley is professor of Cell Biology and Head of School for Cellular and Molecular Medicine at the University of Bristol. She was previously a professor at King's College London.
Vengalil Krishna Kumar Chatterjee is a British endocrinologist. He is a professor of endocrinology in the Department of Medicine at the University of Cambridge and a fellow of Churchill College, Cambridge. He is also the director of the Cambridge Clinical Research Centre, part of the National Institute for Health Research (NIHR).
Richard Somerset Houlston is a British medical geneticist. He is a professor of molecular and population genetics at the Institute of Cancer Research in London.
Andrew John King is a Professor of Neurophysiology and Wellcome Trust Principal Research Fellow in the Department of Physiology, Anatomy and Genetics at the University of Oxford and a Fellow of Merton College, Oxford.
Richard Malcolm Marais is Director of the Cancer Research UK (CRUK) Manchester Institute and Professor of Molecular Oncology at the University of Manchester.
Sir Richard Henry Treisman is a British scientist specialising in the molecular biology of cancer. Treisman is a director of research at the Francis Crick Institute in London.
(Robert) Charles Swanton is British physician scientist specialising in oncology and cancer research. Swanton is a senior group leader at London's Francis Crick Institute, Royal Society Napier Professor in Cancer and thoracic medical oncologist at University College London and University College London Hospitals, co-director of the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, and Chief Clinician of Cancer Research UK.
Caetano Maria Pacheco Pais dos Reis e Sousa is a senior group leader at the Francis Crick Institute and a professor of Immunology at Imperial College London.
Ian Tomlinson is a director of the Institute of Cancer and Genomic Sciences at the University of Birmingham.
Anne Goriely is a British geneticist who is a professor of human genetics at the University of Oxford. Her research investigates the molecular mechanisms that underpin genetic variation, particularly mutations in the male germline.
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