Centrosomal protein 85

CEP85
Identifiers
Aliases	CEP85 , CCDC21, centrosomal protein 85
External IDs	MGI: 1917262 HomoloGene: 11254 GeneCards: CEP85
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,278,808 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	134,187,112 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; thoracic diaphragm; ; gastrocnemius muscle; ; vastus lateralis muscle; ; biceps brachii; ; triceps brachii muscle; ; left ventricle; ; deltoid muscle; ; sural nerve;
	Top expressed in
	spermatocyte; ; thymus; ; yolk sac; ; proximal tubule; ; spermatid; ; seminiferous tubule; ; skeletal muscle tissue; ; lip; ; knee joint; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	centrosome ; Golgi apparatus ; spindle pole ; pericentriolar material ; nucleolus ; cytoskeleton ; nucleus ; cytoplasm ; cytosol ; mitochondrion ; microtubule organizing center ;
Biological process	regulation of mitotic centrosome separation ; negative regulation of protein kinase activity ; chromosome segregation ;
	Sources:Amigo / QuickGO
Orthologs
	64793
	70012
	ENSG00000130695
	ENSMUSG00000037443
	Q6P2H3
	Q8BMK0
	NM_001281517 ; NM_001281518 ; NM_022778 ; NM_001319944
	NM_144527
	NP_001268446 ; NP_001268447 ; NP_001306873 ; NP_073615
	NP_653110
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 10, 2022

Centrosomal protein 85 is a protein that in humans is encoded by the CEP85 gene. ^[5]

Function

This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Related Research Articles

Ninein is a protein that in humans is encoded by the NIN gene. Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene. CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.

Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.

Centrosomal protein of 72 kDa is a protein that in humans is encoded by the CEP72 gene.

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. CEP135 is required for the centriolar localization of CEP250.

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene.

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.

Protein Hook homolog 2 (HK2) is a protein that in humans is encoded by the HOOK2 gene.

<span class="mw-page-title-main">TUBG1</span> Tubulin protein

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Tubulin, epsilon 1 is a protein in humans that is encoded by the TUBE1 gene. This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication

Kizuna centrosomal protein is a protein that in humans is encoded by the KIZ gene.

Centrosomal protein 104kDa is a protein that in humans is encoded by the CEP104 gene. Like its Chlamydomonas ortholog, FAP256, it has been shown to localize to the distal ends of both centrioles in the absence of a cilium. During cilium formation, it is found at the tip of the elongating cilium.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130695 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037443 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Centrosomal protein 85" . Retrieved 2018-06-01.

Centrosomal protein 85

Contents

Function

Related Research Articles

References

Further reading