Research and career
John joined Indiana University in 2015. He is an expert in epidemiology and the neurodevelopment impacts of malaria. [2] John works in Kenya and Uganda. [3] John has studied the long term neurodevelopmental impacts of cerebral and severe malaria in children. He has shown that children who suffer from severe malaria have low cognitive scores, and that severe anemia can compromise the economic productivity of a household. [4] He has explored the pathogenesis of malaria, including intestinal injury, kidney injury and coma. John works with local physicians and researchers in Uganda and Kenya, securing training grants to upskill specialists and build local capacity. [1] John revealed a high mortality rate for children in the year after a hospital discharge, and successfully proposed chemoprevention (using medications to prevent the development of disease) as a preventative strategy. [1]
John has studied infection rates in children with Sickle Cell Anemia. In some of the regions John worked in, a quarter of the children suffering from malaria also had a sickle cell trait. [1] He led a study known as NOHARM MTD (Novel use Of Hydroxyurea in an African Region with Malaria – Maximum Tolerated Dose), which showed that hydroxyura can be used to treat malaria and reduce sickle cell infections. [5] NOHARM changed medical guidelines in Uganda, and encouraged efforts to reduce the costs. He contributed to the creation of Global Health Uganda, a research institute in Uganda that provides support and funding to Ugandan researchers. [1]
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