Interstate 65 (I-65) is a major north–south interstate highway in the central United States. As with most primary interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12) and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
Interstate 71 (I-71) is a north–south Interstate Highway in the midwestern and southeastern regions of the United States. Its southern terminus is at an interchange with I-64 and I-65 in Louisville, Kentucky, and its northern terminus at an interchange with I-90 in Cleveland, Ohio. I-71 runs concurrently with I-75 from a point about 20 miles (32 km) south of Cincinnati, Ohio, into Downtown Cincinnati. While most odd numbered Interstates run north–south, I-71 takes more of a northeast–southwest course, with some east–west sections, and is mainly a regional route serving Kentucky and Ohio. It links I-80 and I-90 to I-70 and ultimately links to I-40. Major metropolitan areas served by I-71 include Louisville, Cincinnati, Columbus, and Cleveland.
Maysville is a home rule-class city in Mason County, Kentucky, United States, and is the county seat of Mason County. The population was 8,873 as of the 2020 census. Maysville is on the Ohio River, 66 miles (106 km) northeast of Lexington. It is the principal city of the Maysville Micropolitan Statistical Area, which comprises Mason County. Two bridges cross the Ohio from Maysville to Aberdeen, Ohio: the Simon Kenton Memorial Bridge built in 1931 and the William H. Harsha Bridge built in 2001.
U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
The John A. Roebling Suspension Bridge is a suspension bridge that spans the Ohio River between Cincinnati, Ohio, and Covington, Kentucky. When opened on December 1, 1866, it was the longest suspension bridge in the world at 1,057 feet (322 m) main span, which was later overtaken by John A. Roebling's most famous design of the 1883 Brooklyn Bridge at 1,595.5 feet (486.3 m). Pedestrians use the bridge to get between the hotels, bars, restaurants, and parking lots in Northern Kentucky. The bar and restaurant district at the foot of the bridge on the Kentucky side is known as Roebling Point.
U.S. Route 52 (US 52) is a major U.S. Highway in the Central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and it is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota, at the Canadian border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
U.S. Route 25 or U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 750 miles (1,210 km) in the Southern and Midwestern U.S. Its southern terminus is in Brunswick, Georgia, from where it proceeds mostly due north, passing through the cities of Augusta, Georgia; Greenville, South Carolina; and Asheville, North Carolina, before dividing into two branches, known as US 25W and US 25E between Newport, Tennessee, and North Corbin, Kentucky. After passing through Richmond and Lexington, Kentucky, it reaches its northern terminus at Ohio state line in Covington, Kentucky. The route is an important crossing of the Appalachian Mountains, and it is covered by three of the corridors of the Appalachian Development Highway System (ADHS). When the highway was originally established in 1926, the route extended from North Augusta, South Carolina, to Port Huron, Michigan. The southern end was extended to its current terminus in 1936, while the northern end was truncated in 1974.
U.S. Route 42 is an east–west United States highway that runs southwest–northeast for 350 miles (560 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling northeast, the highway ends in downtown Cleveland and traveling southwest ends in Louisville.
Interstate 471 (I-471) is a 5.75-mile-long (9.25 km) Interstate Highway, linking I-71 in Downtown Cincinnati, Ohio, to I-275 in Highland Heights, Kentucky. South of I-275, the expressway continues south to U.S. Route 27 (US 27) as unsigned Kentucky Route 471 (KY 471).
Interstate 275 (I-275) is an 83.71-mile-long (134.72 km) highway in Ohio, Indiana, and Kentucky that forms a complete beltway around the Cincinnati metropolitan area and includes a part in a state (Indiana) not entered by the parent route. It had been the only auxiliary Interstate that enters three states, but that changed in July 2018 when I-295 in Delaware and New Jersey was extended into Pennsylvania. It is the longest beltway with an Interstate highway designation in the United States, enclosing an area of over 250,000 acres (100,000 ha). It is also the third longest beltway overall in the United States; only the Sam Houston Tollway and the Grand Parkway, both encircling Greater Houston, are longer. For a short distance in northwest Hamilton County, it overlaps with I-74 and US Route 52 (US 52). It is also concurrent with US 52 very briefly in southern Hamilton County as well.
The Brent Spence Bridge is a double decker, cantilevered truss bridge that carries Interstates 71 and 75 across the Ohio River between Covington, Kentucky and Cincinnati, Ohio. The top deck carries Kentucky-bound traffic while the bottom deck carries Ohio-bound traffic.
U.S. Route 127 (US 127) is a 758-mile-long (1,220 km) north–south U.S. Highway in the eastern half of the United States. The southern terminus of the route is at US 27 in Chattanooga, Tennessee. The northern terminus is at Interstate 75 (I-75) near Grayling, Michigan. Since 1987, it has been the core of the annual World's Longest Yard Sale, also known as the Highway 127 Corridor Sale, which now stretches 690 miles (1,110 km) from Addison, Michigan, to Gadsden, Alabama. The sale, held every August, was started to demonstrate that the older U.S. Highway System has something to offer that the Interstate Highway System does not. In Michigan, US 127 tripled in length in 2002, taking mileage from its parent, US 27.
The Taylor–Southgate Bridge is a continuous truss bridge that was built in 1995. It has a main span of 850 feet (260 m), and a total span of 1,850 feet (560 m). The bridge carries U.S. Route 27 across the Ohio River, connecting Newport, Kentucky and Cincinnati, Ohio.
The C&O Railroad bridge is a cantilever truss bridge carrying the CSX Transportation Cincinnati Terminal Subdivision over the Ohio River. It was the first railroad bridge connecting Cincinnati, Ohio, and Covington, Kentucky.
Interstate 75 (I-75) is a part of the Interstate Highway System that runs 1,786.47 miles (2,875.04 km) from Miami Lakes, Florida to the Canada–United States border at Sault Ste. Marie, Michigan. In the U.S. state of Kentucky, I-75 runs through the eastern half of the state, from the Tennessee state line near the city of Williamsburg to the Ohio state line near Covington. The Interstate serves the state's second-most populous city, Lexington. Outside of it, the route is mostly rural or suburban in nature, mainly providing access to other cities via state and U.S. Highways. The major landscapes traversed by I-75 include the rolling hills and mountains of the Cumberland Plateau, the flat Bluegrass region, the urban core of Lexington, and the highly urbanized suburbs of Northern Kentucky; it also very briefly crosses through the Eastern Kentucky Coalfield at its southernmost stretch and passes near the Daniel Boone National Forest in London.
Interstate 65 (I-65) is part of the Interstate Highway System that runs 887.30 miles (1,427.97 km) north–south from Mobile, Alabama, to Gary, Indiana. The highway crosses Kentucky from south to north, from the Tennessee state line near Franklin to the Indiana state line in Louisville. I-65 passes through three of Kentucky's ten largest cities—Bowling Green, Elizabethtown, and Louisville—and serves Mammoth Cave National Park and Fort Knox. Kentucky was the first state to complete its portion of I-65, with the final section, located near Franklin, opening in 1970.
U.S. Route 25 (US 25) runs for 176.882 miles (284.664 km) across the state of Kentucky from the split between US 25E and US 25W in North Corbin to US 42/US 127 at the Ohio state line in Covington.
US Highway 127 (US 127) is a part of the United States Numbered Highway System that runs from Chattanooga, Tennessee, to the Lower Peninsula of Michigan. In Ohio, the highway runs 194.27 miles (312.65 km) from the Ohio River in Cincinnati to the Michigan state line north of West Unity. US 127 runs south to north in Ohio's westernmost counties along the border of Indiana. The highway is a main route connecting many small towns, including eight county seats. The highway was first designated in 1926. Its route ended in downtown Toledo before being realigned to its current route in 1930.
U.S. Route 127 (US 127) in Kentucky runs 207.7 miles (334.3 km) from the Tennessee state line in rural Clinton County to the Ohio state line in Cincinnati. The southern portion of the route is mostly rural, winding through various small towns along the way. It later runs through the state capital of Frankfort before continuing north, eventually passing through several Cincinnati suburbs in Northern Kentucky, joining US 42 near Warsaw and US 25 in Florence before crossing the Ohio River via the Clay Wade Bailey Bridge.
Transportation in Cincinnati includes sidewalks, roads, public transit, bicycle paths, and regional and international airports. Most trips are made by car, with transit and bicycles having a relatively low share of total trips; in a region of just over 2 million people, less than 80,000 trips are made with transit on an average day. The city is sliced by three major interstate highways, I-71, I-74 and I-75, and circled by a beltway several miles out from the city limits. The region is served by two separate transit systems, one on each side of the river. SORTA, on the Ohio side is about six times larger than TANK on the Kentucky side.
US 25 / US 42 / US 127 
