Cock's peculiar tumour

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Cock's peculiar tumour
Specialty Oncology

Cock's peculiar tumour is a sebaceous cyst linked growth that can resemble a squamous cell carcinoma. [1] The name is given after a 19th-century English surgeon Edward Cock. [2] The proliferating cyst is usually solitary, but it often arises from a simple trichilemmal cysts in the hair follicle epithelium and these are multiple in 70% of cases. They are most commonly found on the scalp where the proliferating trichilemmal cyst will grow to a large size and ulcerate. Chronic inflammation can cause the cyst to take the form of a granuloma. This granuloma mimics a squamous-cell carcinoma (both clinically and histologically) and these ulcerating solitary cysts are called Cock's peculiar tumour. [3]

Chronic inflammation causes the cyst to take the form of a granuloma. This granuloma mimics a squamous cell tumour. The most common sites are the ones where one can find hairs. These are, scalp and scrotum.

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Parotid gland

The parotid gland is a major salivary gland in many animals. In humans, the two parotid glands are present on either side of the mouth and in front of both ears. They are the largest of the salivary glands. Each parotid is wrapped around the mandibular ramus, and secretes serous saliva through the parotid duct into the mouth, to facilitate mastication and swallowing and to begin the digestion of starches. There are also two other types of salivary glands; they are submandibular and sublingual glands. Sometimes accessory parotid glands are found close to the main parotid glands.

Squamous cell skin cancer

Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma. It usually presents as a hard lump with a scaly top but can also form an ulcer. Onset is often over months. Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer. When confined to the outermost layer of the skin, a precancerous or in situ form of cSCC is known as Bowen's disease.

Renal cell carcinoma

Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases. RCC occurrence shows a male predomiance over women with a ratio of 1.5:1. RCC most commonly occurs between 6th and 7th decade of life.

Scalp Anatomical area bordered by the human face at the front, and by the neck at the sides and back

The scalp is the anatomical area bordered by the human face at the front, and by the neck at the sides and back.

Dermoid cyst

A dermoid cyst is a teratoma of a cystic nature that contains an array of developmentally mature, solid tissues. It frequently consists of skin, hair follicles, and sweat glands, while other commonly found components include clumps of long hair, pockets of sebum, blood, fat, bone, nail, teeth, eyes, cartilage, and thyroid tissue.

Basal-cell carcinoma Most common type of skin cancer

Basal-cell carcinoma (BCC), also known as basal-cell cancer, is the most common type of skin cancer. It often appears as a painless raised area of skin, which may be shiny with small blood vessels running over it. It may also present as a raised area with ulceration. Basal-cell cancer grows slowly and can damage the tissue around it, but it is unlikely to spread to distant areas or result in death.

Epidermoid cyst Benign cyst usually found on the skin

An epidermoid cyst or epidermal inclusion cyst is a benign cyst usually found on the skin. The cyst develops out of ectodermal tissue. Histologically, it is made of a thin layer of squamous epithelium.

The oral mucosa is the mucous membrane lining the inside of the mouth. It comprises stratified squamous epithelium, termed "oral epithelium", and an underlying connective tissue termed lamina propria. The oral cavity has sometimes been described as a mirror that reflects the health of the individual. Changes indicative of disease are seen as alterations in the oral mucosa lining the mouth, which can reveal systemic conditions, such as diabetes or vitamin deficiency, or the local effects of chronic tobacco or alcohol use. The oral mucosa tends to heal faster and with less scar formation compared to the skin. The underlying mechanism remains unknown, but research suggests that extracellular vesicles might be involved.

Pyogenic granuloma A vascular tumor on both mucosa and skin

Pyogenic granuloma or pyogenic fibroma is a vascular tumor that occurs on both mucosa and skin, and appears as an overgrowth of tissue due to irritation, physical trauma, or hormonal factors. It is often found to involve the gums, the skin and nasal septum, and has also been found far from the head such as in the thigh.

Oral Medicine is defined by the American Academy of Oral Medicine as the discipline of dentistry concerned with the oral health care of medically complex patients – including the diagnosis and management of medical conditions that affect the oral and maxillofacial region. An oral medicine doctor has received additional specialized training and experience in the diagnosis and management of oral mucosal abnormalities including Oral cancer, salivary gland disorders, temporomandibular disorders and facial pain, taste and smell disorders; and recognition of the oral manifestations of systemic and infectious diseases. It lies at the interface between medicine and dentistry. An oral medicine doctor is trained to diagnose and manage patients with disorders of the orofacial region, essentially as a "physician of the mouth."

Sialadenitis

Sialadenitis (sialoadenitis) is inflammation of salivary glands, usually the major ones, the most common being the parotid gland, followed by submandibular and sublingual glands. It should not be confused with sialadenosis (sialosis) which is a non-inflammatory enlargement of the major salivary glands.

Dentigerous cyst

Dentigerous cyst, also known as follicular cyst is an epithelial-lined developmental cyst formed by accumulation of fluid between the reduced enamel epithelium and crown of an unerupted tooth. It is formed when there is an alteration in the reduced enamel epithelium and encloses the crown of an unerupted tooth at the cemento-enamel junction. Fluid is accumulated between reduced enamel epithelium and the crown of an unerupted tooth. Dentigerous cyst is the second most common form of benign developmental odontogenic cysts.

Desquamative gingivitis is an erythematous (red), desquamatous (shedding) and ulcerated appearance of the gums. It is a descriptive term and can be caused by several different disorders.

Periapical cyst

Commonly known as a dental cyst, the periapical cyst is the most common odontogenic cyst. It may develop rapidly from a periapical granuloma, as a consequence of untreated chronic periapical periodontitis.

Odontogenic keratocyst

An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. It most often affects the posterior mandible and most commonly presents in the third decade of life. Odontogenic keratocysts make up around 19% of jaw cysts.

Trichilemmal cyst Common cyst that forms from a hair follicle

A trichilemmal cyst is a common cyst that forms from a hair follicle, most often on the scalp, and is smooth, mobile and filled with keratin, a protein component found in hair, nails, skin, and horns. Trichilemmal cysts are clinically and histologically distinct from trichilemmal horns, which are much rarer and not limited to the scalp. Rarely, these cysts may grow more extensively and form rapidly multiplying trichilemmal tumors, also called proliferating trichilemmal cysts, which are benign but may grow aggressively at the cyst site. Very rarely, trichilemmal cysts can become cancerous.

Malignant chondroid syringoma Type of skin cancer

A malignant chondroid syringoma is a very uncommon cutaneous (skin) condition characterised by an adnexal eccrine tumour.

Skin cancer, or neoplasia, is the most common type of cancer diagnosed in horses, accounting for 45 to 80% of all cancers diagnosed. Sarcoids are the most common type of skin neoplasm and are the most common type of cancer overall in horses. Squamous-cell carcinoma is the second-most prevalent skin cancer, followed by melanoma. Squamous-cell carcinoma and melanoma usually occur in horses greater than 9-years-old, while sarcoids commonly affect horses 3 to 6 years old. Surgical biopsy is the method of choice for diagnosis of most equine skin cancers, but is contraindicated for cases of sarcoids. Prognosis and treatment effectiveness varies based on type of cancer, degree of local tissue destruction, evidence of spread to other organs (metastasis) and location of the tumor. Not all cancers metastasize and some can be cured or mitigated by surgical removal of the cancerous tissue or through use of chemotherapeutic drugs.

Conjunctival squamous cell carcinoma and corneal intraepithelial neoplasia comprise what are called ocular surface squamous cell neoplasias. SCC is the most common malignancy of the conjunctiva in the US, with a yearly incidence of 1-2.8 per 100,000. Risk factors for the disease are exposure to sun, exposure to UVB, and light-colored skin. Other risk factors include radiation, smoking, HPV, arsenic, and exposure to polycyclic hydrocarbons.

References

  1. Ramachandran, Manoj; Adam Poole (2003). Clinical cases and OSCEs in surgery. Elsevier Health Sciences. p. 9. ISBN   978-0-443-07044-0 . Retrieved May 24, 2009.
  2. Kumar, S. Sujith; Selvakumar, Muthiah; Thirunavukuarasu, R. (2012). "Cock's peculiar tumour". Indian Journal of Surgery. 75 (4): 325–326. doi:10.1007/s12262-012-0464-1. PMC   3726821 . PMID   24426466.
  3. Firkin, Barry G.; Whitworth, Judith A. (1996). Dictionary of Medical Eponyms (2nd ed.). London: Parthenon. pp. 70–71. ISBN   978-1-85-070477-5.