Cognitive neuropsychiatry

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Cognitive neuropsychiatry is a growing multidisciplinary field arising out of cognitive psychology and neuropsychiatry that aims to understand mental illness and psychopathology in terms of models of normal psychological function. A concern with the neural substrates of impaired cognitive mechanisms links cognitive neuropsychiatry to the basic neuroscience. Alternatively, CNP provides a way of uncovering normal psychological processes by studying the effects of their change or impairment.

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The term "cognitive neuropsychiatry" was coined by Prof Hadyn Ellis (Cardiff University ) in a paper "The cognitive neuropsychiatric origins of the Capgras delusion", presented at the International Symposium on the Neuropsychology of Schizophrenia, Institute of Psychiatry, London (Coltheart, 2007).

Although clinically useful, current syndrome classifications (e.g. DSM-IV; ICD-10) have no empirical basis as models of normal cognitive processes. No neuropsychological accounts of how the brain 'works' would ever be complete without a cognitive level of analysis. CNP moves beyond diagnosis and classification to offer a cognitive explanation for established psychiatric behaviours, regardless of whether the symptoms are due to recognised brain pathology or to dysfunction in brain areas or networks without structural lesions.

CNP has been influential, not least because of its early success in explaining some previously bizarre psychiatric delusions, most notably the Capgras delusion, Fregoli delusion and other delusional misidentification syndromes. The Capgras delusion is "explained as the interruption in the covert route to face recognition, namely affective responses to familiar stimuli, localized in the dorsal route of vision from striate cortex to limbic system. According to standard molecular hypotheses, acute delusions are the result of a dysregulated activity of some neuromodulators." [1]

Additionally, the study of cognitive neuropsychiatry has shown to intersect with the study of philosophy. This intersection revolves around a reconsideration of the mind-body relationship and the contemplation of moral issues that can arise by fields such as neuropsychopathology. For example, it has been under consideration whether or not Parkinson's patients should be held morally accountable for their physical actions. This discussion and study has taken place due to the discovery that under certain circumstances, Parkinson's patients can initiate and control their own movement. Examples such as this are cause for difficult judgement calls, i.e. "about who is mad and who is bad" (Stein 1999). Cognitive neuropsychiatry has also explored the difference between implicit and explicit cognition, especially in catatonic patients. For more information on the bridge between neuropsychiatry and philosophy see (e.g., Stein, Dan (1999). Philosophy, Psychiatry, & Psychology).

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A delusion is a false fixed belief that is not amenable to change in light of conflicting evidence. As a pathology, it is distinct from a belief based on false or incomplete information, confabulation, dogma, illusion, hallucination, or some other misleading effects of perception, as individuals with those beliefs are able to change or readjust their beliefs upon reviewing the evidence. However:

Philosophy of psychology is concerned with the philosophical foundations of the study of psychology. It deals with both epistemological and ontological issues and shares interests with other fields, including philosophy of mind and theoretical psychology. Philosophical and theoretical psychology are intimately tied and are therefore sometimes used interchangeably or used together. However, philosophy of psychology relies more on debates general to philosophy and on philosophical methods, whereas theoretical psychology draws on multiple areas.

<span class="mw-page-title-main">Neurocognition</span> Cognitive functions related to a brain region

Neurocognitive functions are cognitive functions closely linked to the function of particular areas, neural pathways, or cortical networks in the brain, ultimately served by the substrate of the brain's neurological matrix. Therefore, their understanding is closely linked to the practice of neuropsychology and cognitive neuroscience, two disciplines that broadly seek to understand how the structure and function of the brain relate to cognition and behaviour.

Capgras delusion or Capgras syndrome is a psychiatric disorder in which a person holds a delusion that a friend, spouse, parent, or another close family member has been replaced by an identical impostor. It is named after Joseph Capgras (1873–1950), the French psychiatrist who first described the disorder.

The Fregoli delusion is a rare disorder in which a person holds a delusional belief that different people are in fact a single person who changes appearance or is in disguise. The syndrome may be related to a brain lesion and is often of a paranoid nature, with the delusional person believing themselves persecuted by the person they believe is in disguise.

Delusional misidentification syndrome is an umbrella term, introduced by Christodoulou for a group of delusional disorders that occur in the context of mental and neurological illness. They all involve a belief that the identity of a person, object, or place has somehow changed or has been altered. As these delusions typically only concern one particular topic, they also fall under the category called monothematic delusions.

<span class="mw-page-title-main">Cognitive neuropsychology</span>

Cognitive neuropsychology is a branch of cognitive psychology that aims to understand how the structure and function of the brain relates to specific psychological processes. Cognitive psychology is the science that looks at how mental processes are responsible for our cognitive abilities to store and produce new memories, produce language, recognize people and objects, as well as our ability to reason and problem solve. Cognitive neuropsychology places a particular emphasis on studying the cognitive effects of brain injury or neurological illness with a view to inferring models of normal cognitive functioning. Evidence is based on case studies of individual brain damaged patients who show deficits in brain areas and from patients who exhibit double dissociations. Double dissociations involve two patients and two tasks. One patient is impaired at one task but normal on the other, while the other patient is normal on the first task and impaired on the other. For example, patient A would be poor at reading printed words while still being normal at understanding spoken words, while the patient B would be normal at understanding written words and be poor at understanding spoken words. Scientists can interpret this information to explain how there is a single cognitive module for word comprehension. From studies like these, researchers infer that different areas of the brain are highly specialised. Cognitive neuropsychology can be distinguished from cognitive neuroscience, which is also interested in brain damaged patients, but is particularly focused on uncovering the neural mechanisms underlying cognitive processes.

The syndrome of subjective doubles is a rare delusional misidentification syndrome in which a person experiences the delusion that they have a double or Doppelgänger with the same appearance, but usually with different character traits, that is leading a life of its own. The syndrome is also called the syndrome of doubles of the self, delusion of subjective doubles, or simply subjective doubles. Sometimes, the patient is under the impression that there is more than one double. A double may be projected onto any person, from a stranger to a family member.

<span class="mw-page-title-main">Institute of Psychiatry, Psychology and Neuroscience</span> Research institution in London, England

The Institute of Psychiatry, Psychology and Neuroscience (IoPPN) is a research institution dedicated to discovering what causes mental illness and diseases of the brain. In addition, its aim is to help identify new treatments for them and ways to prevent them in the first place. The IoPPN is a faculty of King's College London, England, previously known as the Institute of Psychiatry (IoP).

Neuropsychiatry or Organic Psychiatry is a branch of medicine that deals with psychiatry as it relates to neurology, in an effort to understand and attribute behavior to the interaction of neurobiology and social psychology factors. Within neuropsychiatry, the mind is considered "as an emergent property of the brain", whereas other behavioral and neurological specialties might consider the two as separate entities. Neuropsychiatry preceded the current disciplines of psychiatry and neurology, which previously had common training, however, those disciplines have subsequently diverged and are typically practiced separately.

Mirrored-self misidentification is the delusional belief that one's reflection in the mirror is another person – typically a younger or second version of one's self, a stranger, or a relative. This delusion occurs most frequently in patients with dementia and an affected patient maintains the ability to recognize others' reflections in the mirror. It is caused by right hemisphere cranial dysfunction that results from traumatic brain injury, stroke, or general neurological illness. It is an example of a monothematic delusion, a condition in which all abnormal beliefs have one common theme, as opposed to a polythematic delusion, in which a variety of unrelated delusional beliefs exist. This delusion is also classified as one of the delusional misidentification syndromes (DMS). A patient with a DMS condition consistently misidentifies places, objects, persons, or events. DMS patients are not aware of their psychological condition, are resistant to correction and their conditions are associated with brain disease – particularly right hemisphere brain damage and dysfunction.

A monothematic delusion is a delusional state that concerns only one particular topic. This is contrasted by what is sometimes called multi-thematic or polythematic delusions where the person has a range of delusions. These disorders can occur within the context of schizophrenia or dementia or they can occur without any other signs of mental illness. When these disorders are found outside the context of mental illness, they are often caused by organic dysfunction as a result of traumatic brain injury, stroke, or neurological illness.

This glossary covers terms found in the psychiatric literature; the word origins are primarily Greek, but there are also Latin, French, German, and English terms. Many of these terms refer to expressions dating from the early days of psychiatry in Europe.

Pierre Flor-Henry is a Canadian psychiatrist, researcher, lecturer, and professor. His most important initial contribution was the demonstration in the study of epileptic psychosis, that schizophrenia relates to left and manic-depressive states relate to right hemisphere epilepsies.

<span class="mw-page-title-main">Grandiose delusions</span> Subtype of delusion

Grandiose delusions (GD), also known as delusions of grandeur or expansive delusions, are a subtype of delusion that occur in patients with a wide range of psychiatric diseases, including two-thirds of patients in a manic state of bipolar disorder, half of those with schizophrenia, patients with the grandiose subtype of delusional disorder, frequently in narcissistic personality disorder, and a substantial portion of those with substance abuse disorders. GDs are characterized by fantastical beliefs that one is famous, omnipotent, wealthy, or otherwise very powerful. The delusions are generally fantastic and typically have a religious, science fictional, or supernatural theme. There is a relative lack of research into GD, in contrast to persecutory delusions and auditory hallucinations. Around 10% of healthy people experience grandiose thoughts at some point in their lives but do not meet full criteria for a diagnosis of GD.

John Charles Cutting is a British psychiatrist specialising in schizophrenia research. He has written a number of books, and articles and reviews in professional journals, on the subjects of psychiatry, clinical psychology, schizophrenia and the functioning of the right cerebral hemisphere of the brain.

The diagnosis of schizophrenia, a psychotic disorder, is based on criteria in either the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, or the World Health Organization's International Classification of Diseases (ICD). Clinical assessment of schizophrenia is carried out by a mental health professional based on observed behavior, reported experiences, and reports of others familiar with the person. Diagnosis is usually made by a psychiatrist. Associated symptoms occur along a continuum in the population and must reach a certain severity and level of impairment before a diagnosis is made. Schizophrenia has a prevalence rate of 0.3-0.7% in the United States

In psychology, confabulation is a memory error defined as the production of fabricated, distorted, or misinterpreted memories about oneself or the world. It is generally associated with certain types of brain damage or a specific subset of dementias. While still an area of ongoing research, the basal forebrain is implicated in the phenomenon of confabulation. People who confabulate present with incorrect memories ranging from subtle inaccuracies to surreal fabrications, and may include confusion or distortion in the temporal framing of memories. In general, they are very confident about their recollections, even when challenged with contradictory evidence.

<span class="mw-page-title-main">Cotard's syndrome</span> Delusion that one is dead or non-existent

Cotard's syndrome, also known as Cotard's delusion or walking corpse syndrome, is a rare mental disorder in which the affected person holds the delusional belief that they are dead, do not exist, are putrefying, or have lost their blood or internal organs. Statistical analysis of a hundred-patient cohort indicated that denial of self-existence is present in 45% of the cases of Cotard's syndrome; the other 55% of the patients presented with delusions of immortality.

Professor Susan Rossell is a British researcher based at Swinburne University of Technology specialising in Neuropsychology and Neuroimaging. Originally from Nottingham, UK; she now resides in Melbourne, Australia. Her research on the neuropsychology of schizophrenia and body dysmorphic disorder is internationally recognised.

References

  1. Sirgiovanni, Elisabetta (2009). "Mechanistic Approach to Psychiatric Classification" (PDF). Dialogues in Philosophy, Mental and Neuro Sciences. 2 (2): 45–49.

Further reading