Coiled-coil domain containing 88b

CCDC88B
Identifiers
Aliases	CCDC88B , BRLZ, CCDC88, HKRP3, gipie, coiled-coil domain containing 88B
External IDs	OMIM: 611205 MGI: 1925567 HomoloGene: 49992 GeneCards: CCDC88B
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,357,534 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,835,579 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; spleen; ; appendix; ; monocyte; ; bone marrow cells; ; blood; ; lymph node; ; upper lobe of left lung; ; minor salivary gland; ; right lung;
	Top expressed in
	thymus; ; spermatocyte; ; spermatid; ; bone marrow; ; spleen; ; blood; ; seminiferous tubule; ; visual cortex; ; jejunum; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding ; dynein light intermediate chain binding ;
Cellular component	membrane ; cytoplasm ; endoplasmic reticulum ; Golgi apparatus ; centrosome ; cytoskeleton ;
Biological process	positive regulation of T cell activation ; positive regulation of T cell proliferation ; positive regulation of cytokine production ; defense response to protozoan ; cytoskeleton-dependent intracellular transport ; cytoplasmic microtubule organization ;
	Sources:Amigo / QuickGO
Orthologs
	283234
	78317
	ENSG00000168071
	ENSMUSG00000047810
	A6NC98
	Q4QRL3
	NM_032251
	NM_001081291 ; NM_198008
	NP_115627
	NP_001074760
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 11, 2023

Coiled-coil domain containing 88B is a protein that in humans is encoded by the CCDC88B gene. ^[5]

Function

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009].

Related Research Articles

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

<span class="mw-page-title-main">KIF5B</span> Protein-coding gene in the species Homo sapiens

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene. It is part of the kinesin family of motor proteins.

Calcium-binding and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the CALCOCO1 gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

Protein Hook homolog 1 is a protein that in humans is encoded by the HOOK1 gene.

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.

<span class="mw-page-title-main">KIFC1</span> Protein-coding gene in the species Homo sapiens

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.

Dixin is a protein that in humans is encoded by the DIXDC1 gene. When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.

Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene.

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.

Centrosomal protein of 63 kDa is a protein that in humans is encoded by the CEP63 gene. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.

Protein Hook homolog 2 (HK2) is a protein that in humans is encoded by the HOOK2 gene.

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene. It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

Coiled-coil-helix-coiled-coil-helix domain containing 2 is a protein that in humans is encoded by the CHCHD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168071 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047810 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Coiled-coil domain containing 88B" . Retrieved 2018-05-27.

Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M (March 2011). "Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells". Mol. Biol. Cell. 22 (6): 736–47. doi:10.1091/mbc.E10-08-0724. PMC 3057699 . PMID 21289099.
Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (November 2012). "A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1". Am. J. Respir. Crit. Care Med. 186 (9): 877–85. doi:10.1164/rccm.201204-0708OC. PMID 22837380.
Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD (April 2015). "HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing". J. Immunol. 194 (8): 3984–96. doi:10.4049/jimmunol.1402897. PMC 4390494 . PMID 25762780.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168071 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047810 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Coiled-coil domain containing 88B" . Retrieved 2018-05-27.

[1]

[2]

[3]

[4]

[5]

Coiled-coil domain containing 88b

Contents

Function

Related Research Articles

References

Further reading