![]() | |
![]() | |
Names | |
---|---|
Preferred IUPAC name N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-((trifluoromethyl)sulfonyl)methanesulfonamide | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.157.321 |
EC Number |
|
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
| |
| |
Properties | |
C7H3ClF6N2O4S2 | |
Molar mass | 392.67 g·mol−1 |
Appearance | White solid |
Melting point | 45 °C (113 °F; 318 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
The Comins' reagent is a triflyl-donating reagent that is used to synthesize vinyl triflates from the corresponding ketone enolates or dienolates. [1]
It was first reported in 1992 by Daniel Comins. [2] The vinyl triflates prepared are useful as substrates in the Suzuki reaction [3] or other cross-coupling reactions [4] .
First an enolate is created through deprotonation of the carbonyl compound. Then the nucleophilic oxygen will attack one of the sulfurs while the rest of Comins reagent will work as a leaving group due to the good charge stabilization.