Contactin 6

CNTN6
Identifiers
Aliases	CNTN6 , contactin 6, NB3
External IDs	OMIM: 607220; MGI: 1858223; HomoloGene: 8702; GeneCards: CNTN6; OMA:CNTN6 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) [1] Band 6|6 E1 Start 104,492,790 bp [1] End 104,863,406 bp [1]
Gene ontology Molecular function Notch binding cell-cell adhesion mediator activity Cellular component anchored component of membrane plasma membrane membrane parallel fiber to Purkinje cell synapse anchored component of presynaptic membrane axon Biological process Notch signaling pathway central nervous system development neurogenesis cell adhesion nervous system development neuron differentiation positive regulation of Notch signaling pathway homophilic cell adhesion via plasma membrane adhesion molecules axon guidance dendrite self-avoidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27255 53870 Ensembl ENSG00000134115 ENSMUSG00000030092 UniProt Q9UQ52 Q9JMB8 RefSeq (mRNA) NM_001289080 NM_001289081 NM_014461 NM_017383 RefSeq (protein) NP_001276009 NP_001276010 NP_055276 NP_001336279 NP_001336280 NP_001336281 NP_001336282 NP_001336283 NP_001336284 NP_001336285 NP_001336286 NP_001336287 NP_001336288 NP_001336289 NP_001336290 NP_001336291 NP_059079 Location (UCSC) n/a Chr 6: 104.49 – 104.86 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Contactin 6 is a protein in humans that is encoded by the CNTN6 gene. ^[4]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.

References

1. GRCm38: Ensembl release 89: ENSMUSG00000030092 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Contactin 6".

Further reading

• Manderson EN, Birch AH, Shen Z, Mes-Masson AM, Provencher D, Tonin PN (May 2009). "Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer". International Journal of Gynecological Cancer. 19 (4): 513–25. doi: 10.1111/IGC.0b013e3181a3cd38 . PMID   19509545. S2CID   27315616.
• Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, Berrettini W, Hakonarson H (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa" (PDF). Molecular Psychiatry. 16 (9): 949–59. doi:10.1038/mp.2010.107. PMC   3859494 . PMID   21079607.
• Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, Li X, Wilke RA, Rieder MJ, Williams PT, Ridker PM, Chatterjee A, Rotter JI, Nickerson DA, Stephens M, Krauss RM (March 2010). Zanger U (ed.). "Genome-wide association of lipid-lowering response to statins in combined study populations". PLOS ONE. 5 (3): e9763. Bibcode:2010PLoSO...5.9763B. doi: 10.1371/journal.pone.0009763 . PMC   2842298 . PMID   20339536.
• Kamei Y, Tsutsumi O, Taketani Y, Watanabe K (February 1998). "cDNA cloning and chromosomal localization of neural adhesion molecule NB-3 in human". Journal of Neuroscience Research. 51 (3): 275–83. doi:10.1002/(SICI)1097-4547(19980201)51:3<275::AID-JNR1>3.0.CO;2-D. PMID   9486763. S2CID   43122787.
• Walsh FS, Doherty P (November 1991). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system". Cell Biology International Reports. 15 (11): 1151–66. doi:10.1016/0309-1651(91)90061-M (inactive 25 December 2024). PMID   1838307.
• Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC (November 2003). "Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization". The EMBO Journal. 22 (21): 5666–78. doi:10.1093/emboj/cdg570. PMC   275427 . PMID   14592966.
• Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X (October 2010). "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients". Journal of Psychiatric Research. 44 (14): 971–8. doi:10.1016/j.jpsychires.2010.03.007. PMID   20398908.^{[ permanent dead link ‍]}

External links

• Overview of all the structural information available in the PDB for UniProt : Q9JMB8 (Contactin-6) at the PDBe-KB .