Alternative medicine | |
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![]() A bottle of Covid Organics | |
Claims | Treatment against COVID-19 |
Year proposed | 2020 |
Original proponents | Malagasy Institute of Applied Research |
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Covid-Organics (CVO) is an Artemisia -based drink that Andry Rajoelina, president of Madagascar, claims can prevent and cure Coronavirus disease 2019 (COVID-19). The drink is produced from a species under the Artemisia genus [1] [2] [3] from which artemisinin is extracted for malaria treatment. [4] [5] No publicly available clinical trial data supports the safety or efficacy of this drink.
Covid-Organics was developed and produced in Madagascar by the Malagasy Institute of Applied Research. Madagascar was the first country to decide to integrate Artemisia into COVID-19 treatment when the NGO Maison de l'Artemisia France contacted numerous African countries during the COVID-19 pandemic. At least one researcher from another part of Africa, Dr. Jérôme Munyangi of the Democratic Republic of the Congo, contributed. Some of the research on Artemisia, led by African scientists, had been carried out in France and Canada. [6] On 20 April 2020, Rajoelina announced in a television broadcast that his country had found "preventive and curative" cure for COVID-19. [7] [8] [9] Rajoelina publicly sipped from a bottle of Covid-Organics and ordered a nation-wide distribution to families. [10] In 2022, Covid-Organics is not recommended by the WHO. [11]
On 20 May 2020, Rajoelina announced on his Twitter account that the World Health Organization (WHO) will sign a confidentiality agreement with Madagascar regarding the formulation of CVO in order to perform clinical observation. On 21 May 2020, WHO director general Tedros Adhanom confirmed his video conference with Rajoelina, and that the WHO will cooperate with Madagascar on research and development of COVID-19 therapy. [12] The WHO does not recommend the use of non-pharmaceutical Artemisia plant matter. [13] The official position of WHO is that it "supports scientifically-proven traditional medicine" [14] and "recognizes that traditional, complementary and alternative medicine has many advantages". [15]
A wide range of scientific criticism followed the launch of Covid-Organics from within and outside Africa. Before cooperating with Madagascar, the World Health Organization (WHO) issued a warning against use of an untested COVID-19 remedy and said Africans deserve medicine that went through proper scientific trials. At the time, Covid-Organics efficacy and safety was tested on fewer than 20 people within a period of three weeks. [16] [17] [18] In order to meet established scientific standards, the two parties later agreed on a partnership for Covid-Organics to be registered for WHO's Solidarity trials, an international program for fast tracking clinical trials on COVID-19 treatment candidates. [19] The African Union (AU) demanded detailed scientific data on Covid-Organics for analysis by Africa CDC after it had been briefed by Madagascar authorities about the herbal remedy. [20] [21] [22] Africa Centres for Disease Control and Prevention expressed its interest in data for Covid-Organics for the purpose of quickly scaling up an effective and safe remedy. [23] In April, the Economic Community of West African States (ECOWAS) denied ordering a package of CVO after media reports that it had ordered for CVO and said the West Africa Health Organization (WAHO) would only endorse products shown to be effective and safe for use through well-known scientific procedure. [24] [25] [26] As concerns about the safety of CVO grow, South Africa offered to help Madagascar conduct a clinical trial on the herbal tonic. [27]
There are concerns over widespread usage of Artemisia accelerating drug resistance toward ACTs for malaria treatment. [28]
More than 19 African and Caribbean countries have taken delivery of CVO as of May 2020 to combat COVID-19. [29] [30] On 20 May, Ghanaian government finally placed an order for CVO for testing after weeks of pressure from Ghanaians that the herbal remedy be used to halt the spread of Coronavirus. [31] [32] At the end of April, Equatorial Guinea, among the first to express support for the remedy, sent a special envoy to Madagascar for a donated shipment of CVO. [33] Madagascar sent quantities of the product to at least 10 African countries in 2020. [34]
On 2 October 2020, President Andry Rajoelina inaugurated a medical factory named "Pharmalagasy" and officially started to produce CVO pills named "CVO-plus". [35] [36]
On 5 July 2021, WHO issued a statement announcing the completion of phase 3 clinical trials of the CVO+ dry capsule at the National Center for the Application of Pharmaceutical Research (CNARP) of Madagascar, indicating that the results will be reviewed by the Regional Expert Advisory Committee formed in partnership with Africa CDC. The committee will advise the manufacturer on the next steps to take. [15]
A Phase III clinical trial for CVO+, conducted in Madagascar, was published in September 2022, claiming a significantly higher rate of treatment success and that CVO+ was effective for the treatment of mild-to-moderate forms of COVID-19. [37]
Snake oil is a term used to describe deceptive marketing, health care fraud, or a scam. Similarly, snake oil salesman is a common label used to describe someone who sells, promotes, or is a general proponent of some valueless or fraudulent cure, remedy, or solution. The term comes from the "snake oil" that used to be sold as a cure-all elixir for many kinds of physiological problems. Many 19th-century United States and 18th-century European entrepreneurs advertised and sold mineral oil as "snake oil liniment", making claims about its efficacy as a panacea. Patent medicines that claimed to be a panacea were extremely common from the 18th century until the 20th, particularly among vendors masking addictive drugs such as cocaine, amphetamine, alcohol, and opium-based concoctions or elixirs, to be sold at medicine shows as medication or products promoting health.
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Trick or Treatment? Alternative Medicine on Trial is a 2008 book by Simon Singh and Edzard Ernst. The book evaluates the scientific evidence for alternative medicines such as acupuncture, homeopathy, herbal medicine, and chiropractic, and briefly covers 36 other treatments. It finds that the scientific evidence for these alternative treatments is generally lacking. The authors concluded that homeopathy is merely a placebo.
Andry Nirina Rajoelina is a Malagasy-French politician and businessman who has served as president of Madagascar since 2023. He previously served as president from 2019 to 2023, and was president of a provisional government from 2009 to 2014 following a political crisis and military-backed coup, having held the office of Mayor of Antananarivo for one year prior. Before entering the political arena, Rajoelina was involved in the private sector, including a printing and advertising company called Injet in 1999 and the Viva radio and television networks in 2007.
Miracle Mineral Supplement, often referred to as Miracle Mineral Solution, Master Mineral Solution, MMS or the CD protocol, is a branded name for an aqueous solution of chlorine dioxide, an industrial bleaching agent, that has been falsely promoted as a cure for illnesses including HIV, cancer and the common cold. It is made by mixing aqueous sodium chlorite with an acid. This produces chlorine dioxide, a toxic chemical that can cause nausea, vomiting, diarrhea, and life-threatening low blood pressure due to dehydration.
Traditional African medicine is a range of traditional medicine disciplines involving indigenous herbalism and African spirituality, typically including diviners, midwives, and herbalists. Practitioners of traditional African medicine claim, largely without evidence, to be able to cure a variety of diverse conditions including cancer, psychiatric disorders, high blood pressure, cholera, most venereal diseases, epilepsy, asthma, eczema, fever, anxiety, depression, benign prostatic hyperplasia, urinary tract infections, gout, and healing of wounds and burns and Ebola.
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COVID-19 drug development is the research process to develop preventative therapeutic prescription drugs that would alleviate the severity of coronavirus disease 2019 (COVID-19). From early 2020 through 2021, several hundred drug companies, biotechnology firms, university research groups, and health organizations were developing therapeutic candidates for COVID-19 disease in various stages of preclinical or clinical research, with 419 potential COVID-19 drugs in clinical trials, as of April 2021.
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Albert Rakoto Ratsimamanga was a Malagasy physician, biochemist and diplomat. Born into a disgraced royal family; Ratsimamanga trained as a doctor of exotic medicine in French Madagascar and France, where he pioneered modern nutraceuticals. Ratsimamanga returned to Madagascar and, with his wife, Suzanne Urverg-Ratsimamanga, in 1957, established the Malagasy Institute of Applied Research which specialised in herbal medicine.
Suzanne Urverg-Ratsimamanga was a French-Malagasy Ashkenazi Jewish physician and biochemist. She was married to Albert Rakoto Ratsimamanga, with whom she founded the Malagasy Institute of Applied Research.