Cystoisospora canis

Last updated

Cystoisospora canis
Scientific classification Red Pencil Icon.png
Clade: SAR
Infrakingdom: Alveolata
Phylum: Apicomplexa
Class: Conoidasida
Order: Eucoccidiorida
Family: Sarcocystidae
Genus: Cystoisospora
Species:
C. canis
Binomial name
Cystoisospora canis
(Nemesri, 1960)
Synonyms [1]

Cystoisospora canis, previously known as Isospora canis, is a microscopic, coccidian parasite that causes an intestinal tract infection in dogs. [2] The intestinal tract infection is coccidiosis caused by a protozoa (one-celled organisms) called coccidia. [3]

Contents

Background

Cystoisospora , previously known Isospora , is a genus that causes coccidiosis in humans, dogs and cats. [4] Coccidiosis is multiple gastrointestinal infections caused by members of the sporozoan parasite coccidium which includes Cystoisospora.

Species that can infect dogs are Cystoisospora canis, Cystoisospora ohioensis, Cystoisospora neorivolta, and Cystoisospora burrowsi. C. Canis oocysts are larger in size compared to the other three and the other three are structurally similar to each other but not with C. Canis, making it easy to identify. [2] C. ohioensis, C. burrowsi, and C. neorivolta oocysts are similar in structure so they cannot be distinguished from each other until further diagnosis.

Life cycle and transmission

For a dog to become infected, the dog has to have ingested oocysts that can be found in fecal material or another host animal. When a dog is infected, the parasite can be found in the small intestinal epithelium which are the cells that line the cavity of the small intestine. It can also be found in tissues such as spleen, liver, and mesenteric lymph nodes (located in the walls of the intestines). Sporulated oocyst then releases 8 sporozoites. These sporozoites attack the intestinal epithelial cells where they develop into a schizont. Schizonts are part of the asexual stages where there are three generations of schizonts. After the last part of the multiplication process, gametes are formed. Gametes are part of the sexual stages, and they can invade other cells. Male gametes divide and break out to the host cell, then go invade cells containing the female gamete. Once the male gametes and the female gamete are in the same host cell, they will fuse creating a zygote. The zygote develops into an oocyst. The oocyst then breaks out of the host cell and leaves the host through its feces. The oocyst are noninfectious in the feces but will sporulate in 4 days becoming infectious for the next host and for the cycle to begin again. [5] [6] The clinical signs associated with Cystoisospora canis are severe when the oocysts ingested are sporulated instead of being ingested unsporulated. [7]

Clinical signs

Coccidiosis is not usually a great threat to the dog’s health unless the dog is weak or has a low immune system. [8] In some cases infection is asymptomatic this is generally the case for adult dogs. In other cases mostly found in puppies and older dogs the coccidial parasite can cause anemia, weight loss, abdominal pain, vomiting, anorexia, watery diarrhea, fever, dehydration, and mental depression. [5]

If left untreated it can lead to the death of the infected dog.

Diagnosis

The time between infection and when the parasite can be detected (the prepatent period) is about 9–11 days. To detect the parasite, a fecal flotation examination is performed. This examination is where a sample of stool is examined under a microscope to see if there are parasites present. [8] [9]

Treatments

Antibiotics can decrease the presence of the parasites and restores the dog’s health. The antibiotics should be taken for 10 to 14 days. [8] Some of the antibiotics include sulfadimethoxine and amprolium.

Prevalence

Coccidia is found in 3% to 38% of dogs in North America. [10]

Control and prevention

To prevent coccidia, sanitation is key to make sure the environment is free of feces. Rapid removal of feces is important because C. Canis can develop quickly into the infectious stages of its life cycle. Mature oocysts are resistant to most cleaning products and can live for long periods of time. Using stronger cleaning products that contain ammonia or steam cleaning will kill the infectious oocysts. [8] Another way to prevent infection is to not let the dog ingest rodents which could be carrying the parasites.

Related Research Articles

Isosporiasis Human intestinal disease

Isosporiasis, also known as cystoisosporiasis, is a human intestinal disease caused by the parasite Cystoisospora belli. It is found worldwide, especially in tropical and subtropical areas. Infection often occurs in immuno-compromised individuals, notably AIDS patients, and outbreaks have been reported in institutionalized groups in the United States. The first documented case was in 1915. It is usually spread indirectly, normally through contaminated food or water (CDC.gov).

Coccidia A subclass of protists

Coccidia (Coccidiasina) are a subclass of microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida. As obligate intracellular parasites, they must live and reproduce within an animal cell. Coccidian parasites infect the intestinal tracts of animals, and are the largest group of apicomplexan protozoa.

Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The disease spreads from one animal to another by contact with infected feces or ingestion of infected tissue. Diarrhea, which may become bloody in severe cases, is the primary symptom. Most animals infected with coccidia are asymptomatic, but young or immunocompromised animals may suffer severe symptoms and death.

<i>Eimeria tenella</i> Species of single-celled organism

Eimeria tenella is a species of Eimeria that causes hemorrhagic cecal coccidiosis in young poultry. It is found worldwide.

<i>Eimeria</i> Genus of single-celled organisms

Eimeria is a genus of apicomplexan parasites that includes various species capable of causing the disease coccidiosis in animals such as cattle, poultry, dogs, cats, and smaller ruminants including sheep and goats. Eimeria species are considered to be monoxenous because the life cycle is completed within a single host, and stenoxenous because they tend to be host specific, although a number of exceptions have been identified. Species of this genus infect a wide variety of hosts. Thirty-one species are known to occur in bats (Chiroptera), two in turtles, and 130 named species infect fish. Two species infect seals. Five species infect llamas and alpacas: E. alpacae, E. ivitaensis, E. lamae, E. macusaniensis, and E. punonensis. A number of species infect rodents, including E. couesii, E. kinsellai, E. palustris, E. ojastii and E. oryzomysi. Others infect poultry, rabbits and cattle. For full species list, see below.

<i>Neospora caninum</i> Species of Conoidasida in the apicomplex phylum

Neospora caninum is a coccidian parasite that was identified as a species in 1988. Prior to this, it was misclassified as Toxoplasma gondii due to structural similarities. The genome sequence of Neospora caninum has been determined by the Wellcome Trust Sanger Institute and the University of Liverpool. Neospora caninum is an important cause of spontaneous abortion in infected livestock.

<i>Cryptosporidium parvum</i> Species of single-celled organism

Cryptosporidium parvum is one of several species that cause cryptosporidiosis, a parasitic disease of the mammalian intestinal tract.

<i>Sarcocystis</i> Genus of protists in the apicomplex phylum

Sarcocystis is a genus of protozoan parasites, with many species infecting mammals, reptiles and birds. Its name is dervived from Greek sarx = flesh and kystis = bladder.

Eimeria stiedae is a species of Eimeria that causes hepatic coccidiosis in rabbits. It was observed for the first time by Antonie van Leeuwenhoek in 1674.

<i>Toxocara canis</i> Species of roundworm

Toxocara canis is a worldwide-distributed helminth parasite of dogs and other canids. The name is derived from the Greek word "toxon," meaning bow or quiver, and the Latin word "caro," meaning flesh. They live in the small intestine of the definitive host. In adult dogs, the infection is usually asymptomatic but may be characterized by diarrhea. By contrast, massive infection with Toxocara canis can be fatal in puppies, causing diarrhea, vomiting, an enlarged abdomen, flatulence, and poor growth rate.

<i>Toxascaris leonina</i> Species of roundworm

Toxascaris leonina is a common parasitic roundworm found in dogs, cats, foxes, and related host species. Toxascaris leonina, or T. leonina, is an ascarid nematode, a worldwide distributed helminth parasite which is in a division of eukaryotic parasites that, unlike external parasites such as lice and fleas, live inside their host. The definitive hosts of T. leonina include canids and felines (cats), while the intermediate hosts are usually rodents, such as mice or rats. Infection occurs in the definitive host when the animal eats an infected rodent. While T. leonina can occur in either dogs or cats, it is far more frequent in cats.

Trichuris vulpis is a whipworm that lives in the large intestine of canines in its adult stages. Out of different types of worms, Trichuris vulpis is one of the smaller worms with a size ranging from 30–50 mm in length. As the name suggests, the worm has a whip-like shape with distinct features including a small, narrow anterior head, which is the digestive part of the worm, and a larger posterior tail, which is the reproductive part of the worm. Eggs from T. vulpis are oval shaped with bipolar plugs and contain a thick outer shell. Their sizes range from 72–90 μm in length and 32–40 μm in width. Because of their thick outer shell, T. vulpis eggs are very resistant to environmental extremes such as freezing or hot temperatures, thus allowing for their long viability in the outside world.

Karyolysus is a genus of coccidia. With the exception of K. sonomae whose vertebrate host is the yellow-legged frog, species in this genus only infect lizards of the genus Lacerta.

<i>Cystoisospora</i> Genus of single-celled organisms

Cystoisospora is a genus of parasitic alveolates belonging to the phylum Apicomplexa.

Atoxoplasma is a genus of parasitic alveolates in the phylum Apicomplexa. The species in this genus infect birds. They are spread by the orofaecal route.

<i>Cystoisospora belli</i> Species of single-celled organism

Cystoisospora belli, previously known as Isospora belli, is a parasite that causes an intestinal disease known as cystoisosporiasis. This protozoan parasite is opportunistic in immune suppressed human hosts. It primarily exists in the epithelial cells of the small intestine, and develops in the cell cytoplasm. The distribution of this coccidian parasite is cosmopolitan, but is mainly found in tropical and subtropical areas of the world such as the Caribbean, Central and S. America, India, Africa, and S.E. Asia. In the U.S., it is usually associated with HIV infection and institutional living.

Hammondia hammondi is a species of obligate heteroxenous parasitic alveolates of domestic cats. Intracellular cysts develop mainly in striated muscle. After the ingestion of cysts by cats, a multiplicative cycle precedes the development of gametocytes in the epithelium of the small intestine. Oocyst shedding persists for 10 to 28 days followed by immunity. Cysts in skeletal muscle measure between 100 and 340 μm in length and 40 and 95 μm in width. Some of the intermediate hosts develop low levels of antibody and some cross-immunity against Toxoplasma.

Eimeria zuernii is a species of the parasite Eimeria that causes diarrheic disease known as eimeriosis in cattle, and mainly affects younger animals. The disease is also commonly referred to as coccidiosis. The parasite can be found in cattle around the globe.

Nematopsis (Nee-mah-top-cis) is a genus gregarine Apicomplexan of the family Porosporidae. It is an aquatic parasite of crustaceans with a molluscan intermediate host. Nematopsis has been distinguished from the similar genus Porospora by its resistant and encapsulated oocyst. Little molecular biology has been performed on the members of the Nemaptosis and species are described based on molluscan and crustacean hosts as well as oocyst structure. A total of 38 species have been described and are found all over the world.

Eimeria bovis is a paraiste belonging to the genus Eimeria and is found globally. The pathogen can cause a diarrheic disease in cattle referred to as either eimeriosis or coccidiosis. The infection predominantly cause disease in younger animals.

References

  1. "Cystoisospora canis" (HTML). NCBI taxonomy. Bethesda, MD: National Center for Biotechnology Information. Retrieved 16 January 2019.
  2. 1 2 Houk, Alice E.; O'Connor, Thomas; Pena, Hilda F. J.; Gennari, Solange Maria; Zajac, Anne M.; Lindsay, David S. (October 2013). "Experimentally induced clinical Cystoisospora canis coccidiosis in dogs with prior natural patent Cystoisospora ohioensis-like or C. canis infections". Journal of Parasitology. 99 (5): 892–895. doi:10.1645/13-197.1. hdl: 10919/49049 . PMID   23517349.
  3. "Coccidiosis in Dogs". VCA Hospitals. Retrieved 2014-12-10.
  4. Frenkel, JK (August 1977). "Besnoitia wallacei of cats and rodents: with a reclassification of other cyst-forming isosporoid coccidia". The Journal of Parasitology. 63 (4): 611–28. doi:10.2307/3279560. JSTOR   3279560. PMID   407344.
  5. 1 2 Mitchell, Sheila M.; Zajac, Anne M.; Lindsay, David S. (August 2009). "Development and ultrastructure of Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis) monozoic cysts in two noncanine cell lines". Journal of Parasitology. 95 (4): 793–798. doi:10.1645/GE-1951.1. hdl: 10919/49036 . PMID   20049986.
  6. Nolan. 2004, January 1). Adult Parasite:. Retrieved December 7, 2014, from "Archived copy". Archived from the original on 2014-12-17. Retrieved 2014-12-10.{{cite web}}: CS1 maint: archived copy as title (link)
  7. Dubey, JP (August 1975). "Experimental Isopora canis and Isopora felis infection in mice, cats, and dogs". The Journal of Protozoology. 22 (3): 416–7. doi:10.1111/j.1550-7408.1975.tb05195.x. PMID   1159643.
  8. 1 2 3 4 Isospora spp., Isospora canis, Isospora felis. (n.d.). Retrieved December 4, 2014, from "Isospora SPP., Isospora canis, Isospora felis". Archived from the original on 2014-12-15. Retrieved 2014-12-10.
  9. "Fecal Flotation". VCA Hospitals. Retrieved 2014-12-10.
  10. CAPC. (2014, January 1). Coccidia Prevalence. Retrieved December 7, 2014, from http://www.capcvet.org/capc-recommendations/coccidia-prevalence Archived 2014-12-10 at the Wayback Machine