Cytokine dependent hematopoietic cell linker

CLNK
Identifiers
Aliases	CLNK , MIST, cytokine dependent hematopoietic cell linker
External IDs	OMIM: 611434 MGI: 1351468 HomoloGene: 8450 GeneCards: CLNK
Gene location (Human)
Chr.	Chromosome 4 (human)
End	10,684,768 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	39,034,155 bp
RNA expression pattern
	Top expressed in
	kidney; ; ventricle; ; left ventricle; ; renal cortex; ; salivary gland; ; atrium; ; sural nerve; ; anterior pituitary; ; lymph node;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding ;
Cellular component	intracellular anatomical structure ;
Biological process	GO:0007243 intracellular signal transduction ; immune response ; transmembrane receptor protein tyrosine kinase signaling pathway ; positive regulation of signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	116449
	27278
	ENSG00000109684
	ENSMUSG00000039315
	Q7Z7G1
	Q9QZE2
	NM_052964
	NM_013748
	NP_443196
	NP_038776
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 03, 2022

Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. ^[5]

Function

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).

Related Research Articles

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Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene. MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain. MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109684 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039315 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Cytokine dependent hematopoietic cell linker" . Retrieved 2017-09-06.

Cytokine dependent hematopoietic cell linker

Contents

Function

Related Research Articles

References

Further reading