DCAF8

DCAF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3I8E
Identifiers
Aliases	DCAF8 , GAN2, H326, WDR42A, DDB1 and CUL4 associated factor 8
External IDs	OMIM: 615820; MGI: 91860; HomoloGene: 56725; GeneCards: DCAF8; OMA:DCAF8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 160,215,715 bp [1] End 160,262,549 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.54 cM Start 171,975,651 bp [2] End 172,024,572 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland gastric mucosa body of pancreas sural nerve left lobe of thyroid gland right hemisphere of cerebellum right ovary Achilles tendon left ovary Top expressed in neural layer of retina muscle of thigh ventricular zone dentate gyrus of hippocampal formation granule cell zygote aortic valve ascending aorta right kidney spermatocyte primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleoplasm mitochondrion cytosol cytoplasm Cul4-RING E3 ubiquitin ligase complex nucleus Biological process post-translational protein modification protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50717 98193 Ensembl ENSG00000132716 ENSMUSG00000026554 UniProt Q5TAQ8 Q5TAQ9 Q8N7N5 RefSeq (mRNA) NM_015726 NM_153555 NM_001357204 RefSeq (protein) NP_056541 NP_705783 NP_001344133 Location (UCSC) Chr 1: 160.22 – 160.26 Mb Chr 1: 171.98 – 172.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DDB1 and CUL4 associated factor 8 is a protein that in humans is encoded by the DCAF8 gene. ^[5]

Function

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009].

References

1. GRCh38: Ensembl release 89: ENSG00000132716 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026554 – Ensembl, May 2017
3. '"`UNIQ--templatestyles-00000006-QINU`"' "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. '"`UNIQ--templatestyles-00000008-QINU`"' "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DDB1 and CUL4 associated factor 8" . Retrieved 2018-08-23.

Further reading

• Li M, Wang L, Ren X, Zheng C (June 2011). "Host cell targets of tegument protein VP22 of herpes simplex virus 1". Arch. Virol. 156 (6): 1079–84. doi:10.1007/s00705-011-0960-9. PMID   21424732. S2CID   10554037.
• Wu F, Wang S, Xing J, Li M, Zheng C (April 2012). "Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A)". FEBS Lett. 586 (8): 1079–85. doi: 10.1016/j.febslet.2012.02.053 . PMID   22500989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.