DCBLD2

DCBLD2
Identifiers
Aliases	DCBLD2 , CLCP1, ESDN, discoidin, CUB and LCCL domain containing 2
External IDs	OMIM: 608698; MGI: 1920629; HomoloGene: 12499; GeneCards: DCBLD2; OMA:DCBLD2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q12.1|3 Start 98,795,941 bp [1] End 98,901,695 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C1.2 Start 58,408,443 bp [2] End 58,469,727 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium vena cava parotid gland body of tongue synovial joint Skeletal muscle tissue of rectus abdominis cardia pons mucosa of paranasal sinus pylorus Top expressed in decidua atrium pineal gland secondary oocyte epithelium of stomach primary oocyte umbilical cord external carotid artery tail of embryo endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane cell surface integral component of plasma membrane membrane Biological process intracellular receptor signaling pathway wound healing negative regulation of cell growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131566 73379 Ensembl ENSG00000057019 ENSMUSG00000035107 UniProt Q96PD2 Q91ZV3 RefSeq (mRNA) NM_080927 NM_028523 NM_001356484 RefSeq (protein) NP_563615 NP_082799 NP_001343413 Location (UCSC) Chr 3: 98.8 – 98.9 Mb Chr 16: 58.41 – 58.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000057019 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035107 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kobuke K, Furukawa Y, Sugai M, Tanigaki K, Ohashi N, Matsumori A, Sasayama S, Honjo T, Tashiro K (Sep 2001). "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury". The Journal of Biological Chemistry. 276 (36): 34105–14. doi: 10.1074/jbc.M105293200 . hdl: 2433/150206 . PMID   11447234.
6. "Entrez Gene: DCBLD2 discoidin, CUB and LCCL domain containing 2".

Further reading

• Sadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al-Lamki RS, Takahashi T, Tellides G, Bender JR, Rodriguez ER (Sep 2007). "ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis". American Journal of Transplantation. 7 (9): 2098–105. doi:10.1111/j.1600-6143.2007.01919.x. PMID   17697260. S2CID   28463596.
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID   17570516. S2CID   23944956.
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (Sep 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.
• Koshikawa K, Osada H, Kozaki K, Konishi H, Masuda A, Tatematsu Y, Mitsudomi T, Nakao A, Takahashi T (Apr 2002). "Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo". Oncogene. 21 (18): 2822–8. doi:10.1038/sj.onc.1205405. PMID   11973641. S2CID   1747522.
• Nadadur SS, Ehrke MJ, Gurtoo HL (Dec 1999). "A novel TNF-inducible message with putative growth suppressor function". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1489 (2–3): 433–9. doi:10.1016/s0167-4781(99)00189-x. PMID   10673047.