DCHS2

DCHS2
Identifiers
Aliases	DCHS2 , CDH27, CDHJ, CDHR7, PCDH23, PCDHJ, dachsous cadherin-related 2
External IDs	OMIM: 612486; HomoloGene: 130686; GeneCards: DCHS2; OMA:DCHS2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.3 Start 154,231,742 bp [1] End 154,491,799 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Achilles tendon superior frontal gyrus nucleus accumbens smooth muscle tissue muscle layer of sigmoid colon sural nerve body of uterus myometrium caudate nucleus n/a More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding molecular function cadherin binding Cellular component integral component of membrane plasma membrane membrane cellular component Biological process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules biological process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54798 n/a Ensembl ENSG00000197410 ENSG00000284227 n/a UniProt Q6V1P9 n/a RefSeq (mRNA) NM_001142552 NM_001142553 NM_017639 NM_199348 NM_001358235 n/a RefSeq (protein) NP_001136024 NP_001345164 n/a Location (UCSC) Chr 4: 154.23 – 154.49 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene. ^{[3] [4]}

DCHS2 has been implicated in the nose angle (how much a nose is upturned). ^[5] As well as facial genetics ^{[6] [7]}

References

1. ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: dachsous 2 (Drosophila)".
4. Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, et al. (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". Journal of Molecular Biology. 337 (2): 307–317. doi:10.1016/j.jmb.2004.01.026. PMID   15003449.
5. Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616. Bibcode:2016NatCo...711616A. doi:10.1038/ncomms11616. PMC   4874031 . PMID   27193062.
6. Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A (2018). "Facial Genetics: A Brief Overview". Frontiers in Genetics. 9: 462. doi: 10.3389/fgene.2018.00462 . PMC   6198798 . PMID   30386375.
7. Firger J (19 May 2016). "Your nose--Big or small--is shaped by your DNA". Newsweek .

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.