DCTN3

DCTN3
Identifiers
Aliases	DCTN3 , DCTN-22, DCTN22, dynactin subunit 3
External IDs	OMIM: 607387 MGI: 1859251 HomoloGene: 5233 GeneCards: DCTN3
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p13.3 Start 34,613,545 bp [1] End 34,620,523 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A5 Start 41,714,798 bp [2] End 41,723,170 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex anterior pituitary Brodmann area 9 nucleus accumbens skin of abdomen cingulate gyrus caudate nucleus amygdala parotid gland Top expressed in saccule medial ganglionic eminence otic placode superior frontal gyrus facial motor nucleus motor neuron lip barrel cortex brown adipose tissue white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding Cellular component cytoplasm centrosome dynactin complex spindle chromosome microtubule organizing center microtubule associated complex midbody perinuclear region of cytoplasm cleavage furrow chromosome, centromeric region cytoskeleton kinetochore nucleolus cytosol microtubule Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II cell division endoplasmic reticulum to Golgi vesicle-mediated transport G2/M transition of mitotic cell cycle microtubule-based process cell cycle ciliary basal body-plasma membrane docking mitotic cell cycle regulation of G2/M transition of mitotic cell cycle cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11258 53598 Ensembl ENSG00000137100 ENSMUSG00000028447 UniProt O75935 Q9Z0Y1 RefSeq (mRNA) NM_024348 NM_001281425 NM_001281426 NM_001281427 NM_007234 NM_001159565 NM_016890 RefSeq (protein) NP_001268354 NP_001268355 NP_001268356 NP_009165 NP_077324 NP_001153037 NP_058586 Location (UCSC) Chr 9: 34.61 – 34.62 Mb Chr 4: 41.71 – 41.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene. ^{[5] [6] [7]}

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000137100 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028447 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Karki S, LaMonte B, Holzbaur EL (Sep 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". J Cell Biol. 142 (4): 1023–34. doi:10.1083/jcb.142.4.1023. PMC   2132867 . PMID   9722614.
6. Mills DR, Jackson CL (Apr 2001). "Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 166. doi:10.1159/000056892. PMID   11306820. S2CID   84893310.
7. "Entrez Gene: DCTN3 dynactin 3 (p22)".

Further reading

• Karki S, Tokito MK, Holzbaur EL (2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". J. Biol. Chem. 275 (7): 4834–9. doi: 10.1074/jbc.275.7.4834 . PMID   10671518.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.