DDO (gene)

DDO
Identifiers
Aliases	DDO , Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDs	OMIM: 124450 MGI: 1925528 HomoloGene: 101531 GeneCards: DDO
Gene location (Human)
Chr.	Chromosome 6 (human)
End	110,415,562 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	40,557,843 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; right ventricle; ; myocardium; ; Right adrenal gland; ; Left adrenal gland; ; kidney tubule; ; right lobe of liver; ; putamen; ; caudate nucleus; ; endothelial cell;
	Top expressed in
	digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; soleus muscle; ; parotid gland; ; myocardium of ventricle; ; interventricular septum; ; intercostal muscle; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; FAD binding ; signaling receptor binding ; protein binding ; D-amino-acid oxidase activity ; D-aspartate oxidase activity ;
Cellular component	peroxisome ; peroxisomal matrix ; cytosol ; cytoplasm ;
Biological process	insemination ; grooming behavior ; aspartate metabolic process ; D-amino acid metabolic process ; hormone metabolic process ; aspartate catabolic process ; D-amino acid catabolic process ; cellular nitrogen compound metabolic process ; protein targeting to peroxisome ;
	Sources:Amigo / QuickGO
Orthologs
	8528
	70503
	ENSG00000203797
	ENSMUSG00000063428
	Q99489
	Q922Z0
	NM_003649 ; NM_004032
	NM_027442 ; NM_001316716 ; NM_001316717 ; NM_001316718 ; NM_001316719
NP_004023 ; NP_001355099 ; NP_001355100 ; NP_001355101 ; NP_001355102 ;
	NP_001355103 ; NP_001355104 ; NP_001359037
	NP_001303645 ; NP_001303646 ; NP_001303647 ; NP_001303648 ; NP_081718
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.^[5]^[6]

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489 ) transcript variants encoding different isoforms have been found for this gene.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000203797 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063428 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Setoyama C, Miura R (Jul 1997). "Structural and functional characterization of the human brain D-aspartate oxidase". J Biochem. 121 (4): 798–803. doi:10.1093/oxfordjournals.jbchem.a021655. PMID 9163533.
1 2 "Entrez Gene: DDO D-aspartate oxidase".

Barker RF, Hopkinson DA (1977). "The genetic and biochemical properties of the D-amino acid oxidases in human tissues". Ann. Hum. Genet. 41 (1): 27–42. doi:10.1111/j.1469-1809.1977.tb01959.x. PMID 21608. S2CID 40488767.
Van Veldhoven PP, Brees C, Mannaerts GP (1991). "D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man". Biochim. Biophys. Acta. 1073 (1): 203–8. doi:10.1016/0304-4165(91)90203-S. PMID 1991137.
Nagasaki H (1994). "Gender-related differences of mouse liver D-aspartate oxidase in the activity and response to administration of D-aspartate and peroxisome proliferators". Int. J. Biochem. 26 (3): 415–23. doi:10.1016/0020-711X(94)90062-0. PMID 8187937.
Simonic T, Duga S, Negri A, et al. (1997). "cDNA cloning and expression of the flavoprotein D-aspartate oxidase from bovine kidney cortex". Biochem. J. 322 (3): 729–35. doi:10.1042/bj3220729. PMC 1218248 . PMID 9148742.
Amery L, Brees C, Baes M, et al. (1999). "C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal". Biochem. J. 336 (2): 367–71. doi:10.1042/bj3360367. PMC 1219880 . PMID 9820813.
Zaar K, Köst HP, Schad A, et al. (2002). "Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain". J. Comp. Neurol. 450 (3): 272–82. doi:10.1002/cne.10320. PMID 12209855. S2CID 24459809.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000203797 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063428 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9163533-5] Setoyama C, Miura R (Jul 1997). "Structural and functional characterization of the human brain D-aspartate oxidase". J Biochem. 121 (4): 798–803. doi:10.1093/oxfordjournals.jbchem.a021655. PMID 9163533.

[entrez-6] 1 2 "Entrez Gene: DDO D-aspartate oxidase".

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DDO (gene)

Related Research Articles

References

Further reading