DDX10

DDX10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PL3
Identifiers
Aliases	DDX10 , HRH-J8, DEAD-box helicase 10, Dbp4
External IDs	OMIM: 601235 MGI: 1924841 HomoloGene: 20922 GeneCards: DDX10
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q22.3 Start 108,665,058 bp [1] End 108,940,999 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.3 Start 53,009,935 bp [2] End 53,159,353 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon ganglionic eminence kidney tubule left uterine tube kidney body of pancreas Brodmann area 9 islet of Langerhans prefrontal cortex Top expressed in otic placode saccule primitive streak hair follicle maxillary prominence spermatid somite ovary Paneth cell atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus cytoplasm Biological process RNA secondary structure unwinding anterior head development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1662 77591 Ensembl ENSG00000178105 ENSMUSG00000053289 UniProt Q13206 Q80Y44 RefSeq (mRNA) NM_004398 NM_029936 RefSeq (protein) NP_004389 NP_084212 Location (UCSC) Chr 11: 108.67 – 108.94 Mb Chr 9: 53.01 – 53.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene. ^{[5] [6]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000178105 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053289 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics. 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID   8660968.
6. "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wang SC, Lien HC, Xia W, et al. (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251–61. doi: 10.1016/j.ccr.2004.07.012 . PMID   15380516.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Nakao K, Nishino M, Takeuchi K, et al. (2000). "Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome". Intern. Med. 39 (5): 412–5. doi: 10.2169/internalmedicine.39.412 . PMID   10830185.
• Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID   10655059. S2CID   21887748.
• Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts". Int. J. Hematol. 69 (3): 160–4. PMID   10222653.
• Liang WQ, Clark JA, Fournier MJ (1997). "The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein". Mol. Cell. Biol. 17 (7): 4124–32. doi:10.1128/mcb.17.7.4124. PMC   232266 . PMID   9199348.
• Arai Y, Hosoda F, Kobayashi H, et al. (1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10". Blood. 89 (11): 3936–44. doi: 10.1182/blood.V89.11.3936 . PMID   9166830.