DDX17

DDX17
Identifiers
Aliases	DDX17 , P72, RH70, DEAD-box helicase 17
External IDs	OMIM: 608469 MGI: 1914290 HomoloGene: 101101 GeneCards: DDX17
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 38,483,438 bp [1] End 38,507,660 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 79,411,937 bp [2] End 79,430,942 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia middle temporal gyrus Brodmann area 23 endothelial cell germinal epithelium visceral pleura parietal pleura right uterine tube corpus callosum bronchial epithelial cell Top expressed in medullary collecting duct renal corpuscle condyle fossa vas deferens ciliary body iris primitive streak left lung lobe Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding RNA helicase activity protein binding ATP binding helicase activity transcription coactivator activity hydrolase activity nucleic acid binding ATP-dependent activity, acting on RNA RNA binding Cellular component membrane nucleus nuclear speck cytosol nucleoplasm nucleolus cytoplasm Biological process RNA processing RNA secondary structure unwinding regulation of transcription, DNA-templated transcription, DNA-templated regulation of skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II regulation of alternative mRNA splicing, via spliceosome alternative mRNA splicing, via spliceosome regulation of transcription by RNA polymerase II miRNA metabolic process intracellular estrogen receptor signaling pathway androgen receptor signaling pathway epithelial to mesenchymal transition myoblast differentiation immune system process rRNA processing mRNA processing RNA splicing gene silencing defense response to virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10521 67040 Ensembl ENSG00000100201 ENSMUSG00000055065 UniProt Q92841 Q501J6 RefSeq (mRNA) NM_030881 NM_001098504 NM_001098505 NM_006386 NM_001040187 NM_152806 NM_199079 NM_199080 RefSeq (protein) NP_001091974 NP_006377 NP_001035277 NP_690019 NP_951061 NP_951062 Location (UCSC) Chr 22: 38.48 – 38.51 Mb Chr 15: 79.41 – 79.43 Mb PubMed search [3] [4]
Wikidata
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Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene. ^{[5] [6]}

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site. ^[6]

Interactions

DDX17 has been shown to interact with:

• DDX5 (p68), ^[7]
• DHX9 (RNA Helicase A), ^[8]
• HDAC1, ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000100201 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055065 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lamm GM, Nicol SM, Fuller-Pace FV, Lamond AI (Dec 1996). "p72: a human nuclear DEAD box protein highly related to p68". Nucleic Acids Res. 24 (19): 3739–47. doi:10.1093/nar/24.19.3739. PMC   146168 . PMID   8871553.
6. "Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17".
7. Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV (2003). "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. doi:10.1093/nar/gkg236. PMC   149829 . PMID   12595555.
8. Wilson BJ, Giguère V (Nov 2007). "Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis". BMC Genomics. 8: 419. doi: 10.1186/1471-2164-8-419 . PMC   3225811 . PMID   18005418.
9. Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV (Aug 2004). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Mol. Biol. 5: 11. doi: 10.1186/1471-2199-5-11 . PMC   514542 . PMID   15298701.

Further reading

• Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID   9747670.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Uhlmann-Schiffler H, Rössler OG, Stahl H (2002). "The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase". J. Biol. Chem. 277 (2): 1066–75. doi: 10.1074/jbc.M107535200 . PMID   11675387.
• Hönig A, Auboeuf D, Parker MM, O'Malley BW, Berget SM (2002). "Regulation of Alternative Splicing by the ATP-Dependent DEAD-Box RNA Helicase p72". Mol. Cell. Biol. 22 (16): 5698–707. doi:10.1128/MCB.22.16.5698-5707.2002. PMC   133985 . PMID   12138182.
• Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi: 10.1074/jbc.M206194200 . PMID   12171929.
• Lee CG (2002). "RH70, a bidirectional RNA helicase, co-purifies with U1snRNP". J. Biol. Chem. 277 (42): 39679–83. doi: 10.1074/jbc.C200337200 . PMID   12193588.
• Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV (2003). "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. doi:10.1093/nar/gkg236. PMC   149829 . PMID   12595555.
• Fujita T, Kobayashi Y, Wada O, Tateishi Y, Kitada L, Yamamoto Y, Takashima H, Murayama A, Yano T, Baba T, Kato S, Kawabe Y, Yanagisawa J (2003). "Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells". J. Biol. Chem. 278 (29): 26704–14. doi: 10.1074/jbc.M301031200 . PMID   12738788.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV (2005). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Mol. Biol. 5: 11. doi: 10.1186/1471-2199-5-11 . PMC   514542 . PMID   15298701.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.