DDX42

DDX42
Identifiers
Aliases	DDX42 , DDX42P, RHELP, RNAHP, SF3B8, SF3b125, DEAD-box helicase 42
External IDs	OMIM: 613369; MGI: 1919297; HomoloGene: 49137; GeneCards: DDX42; OMA:DDX42 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q23.3 Start 63,773,603 bp [1] End 63,819,317 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E1 Start 106,216,926 bp [2] End 106,249,139 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right uterine tube gastric mucosa left ovary right ovary epithelium of colon Achilles tendon canal of the cervix sural nerve minor salivary glands Top expressed in neural layer of retina ventricular zone tail of embryo neural tube epiblast dentate gyrus of hippocampal formation granule cell lens superior frontal gyrus yolk sac thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component cytoplasm Cajal body membrane nucleus nucleoplasm cytosol nuclear speck nucleolus Biological process protein localization RNA secondary structure unwinding mRNA splicing, via spliceosome regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11325 72047 Ensembl ENSG00000198231 ENSMUSG00000020705 UniProt Q86XP3 Q810A7 RefSeq (mRNA) NM_007372 NM_203499 NM_028074 RefSeq (protein) NP_031398 NP_987095 NP_082350 NP_001348569 NP_001348571 NP_001348572 NP_001348573 Location (UCSC) Chr 17: 63.77 – 63.82 Mb Chr 11: 106.22 – 106.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene. ^{[5] [6]}

Function

This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. ^[6]

Interactions

DDX42 has been shown to interact with SF3B1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000198231 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020705 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID   10727850.
6. "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".
7. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC   126279 . PMID   12234937.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Uhlmann-Schiffler H, Jalal C, Stahl H (2006). "Ddx42p--a human DEAD box protein with RNA chaperone activities". Nucleic Acids Research. 34 (1): 10–22. doi:10.1093/nar/gkj403. PMC   1325199 . PMID   16397294.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC   126279 . PMID   12234937.