DDX43

DDX43
Identifiers
Aliases	DDX43 , CT13, HAGE, DEAD-box helicase 43
External IDs	OMIM: 606286; MGI: 3642857; HomoloGene: 56814; GeneCards: DDX43; OMA:DDX43 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q13 Start 73,394,828 bp [1] End 73,417,566 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E1 Start 78,303,059 bp [2] End 78,330,869 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte gonad testicle sperm right testis left testis Achilles tendon granulocyte gastric mucosa Top expressed in spermatocyte seminiferous tubule Gonadal ridge spermatid embryo embryo morula zygote blastocyst conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding hydrolase activity nucleotide binding nucleic acid binding helicase activity RNA binding Cellular component intracellular anatomical structure nucleolus cytoplasm Biological process RNA secondary structure unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55510 100048658 Ensembl ENSG00000080007 ENSMUSG00000070291 UniProt Q9NXZ2 D3Z6P9 RefSeq (mRNA) NM_018665 NM_001191044 RefSeq (protein) NP_061135 NP_001177973 Location (UCSC) Chr 6: 73.39 – 73.42 Mb Chr 9: 78.3 – 78.33 Mb PubMed search [3] [4]
Wikidata
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Probable ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene. ^{[5] [6]}

Function

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD box family and displays tumor-specific expression. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080007 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070291 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martelange V, De Smet C, De Plaen E, Lurquin C, Boon T (Aug 2000). "Identification on a human sarcoma of two new genes with tumor-specific expression". Cancer Res. 60 (14): 3848–55. PMID   10919659.
6. "Entrez Gene: DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Nagel H, Laskawi R, Eiffert H, Schlott T (2003). "Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands". Mol. Pathol. 56 (4): 226–31. doi:10.1136/mp.56.4.226. PMC   1187325 . PMID   12890744.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Mathieu MG, Knights AJ, Pawelec G, Riley CL, Wernet D, Lemonnier FA, Straten PT, Mueller L, Rees RC, McArdle SE (2007). "HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides". Cancer Immunol. Immunother. 56 (12): 1885–95. doi:10.1007/s00262-007-0331-2. PMC   11030838 . PMID   17487488. S2CID   5801595.