DDX50

DDX50
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E29
Identifiers
Aliases	DDX50 , GU2, GUB, RH-II/GuB, mcdrh, DEAD-box helicase 50, DExD-box helicase 50
External IDs	OMIM: 610373 MGI: 2182303 HomoloGene: 56986 GeneCards: DDX50
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.1 Start 68,901,286 bp [1] End 68,946,847 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 B4 Start 62,451,674 bp [2] End 62,486,997 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon secondary oocyte parietal pleura pericardium tibia mucosa of urinary bladder embryo germinal epithelium islet of Langerhans smooth muscle tissue Top expressed in renal corpuscle dermis ureter submandibular gland maxillary prominence retinal pigment epithelium seminal vesicula islet of Langerhans atrioventricular valve medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component plasma membrane membrane nucleus nucleolus cytoplasm Biological process RNA secondary structure unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79009 94213 Ensembl ENSG00000107625 ENSMUSG00000020076 UniProt Q9BQ39 Q99MJ9 RefSeq (mRNA) NM_024045 NM_053183 NM_001358819 NM_001358820 RefSeq (protein) NP_076950 NP_444413 NP_001345748 NP_001345749 Location (UCSC) Chr 10: 68.9 – 68.95 Mb Chr 10: 62.45 – 62.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded by the DDX50 gene. ^{[5] [6]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000107625 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020076 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Valdez BC, Yang H, Hong E, Sequitin AM (Mar 2002). "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene. 284 (1–2): 53–61. doi:10.1016/S0378-1119(01)00888-5. PMID   11891046.
6. "Entrez Gene: DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.