DDX6

Last updated
DDX6
Protein DDX6 PDB 1vec.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DDX6 , HLR2, P54, RCK, DEAD-box helicase 6, IDDILF, Rck/p54
External IDs OMIM: 600326; MGI: 104976; HomoloGene: 3238; GeneCards: DDX6; OMA:DDX6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001257191
NM_004397

NM_001110826
NM_007841
NM_181324
NM_001357702
NM_001357703

RefSeq (protein)

NP_001244120
NP_004388

NP_001104296
NP_031867
NP_851841
NP_001344631
NP_001344632

Location (UCSC) Chr 11: 118.75 – 118.79 Mb Chr 9: 44.52 – 44.55 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene. [5] [6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110367 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032097 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lu D, Yunis JJ (Jun 1992). "Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3". Nucleic Acids Res. 20 (8): 1967–72. doi:10.1093/nar/20.8.1967. PMC   312313 . PMID   1579499.
  6. 1 2 "Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6".

Further reading