DECR2

DECR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4FC6, 4FC7
Identifiers
Aliases	DECR2 , PDCR, SDR17C1, 2,4-dienoyl-CoA reductase 2, peroxisomal, 2,4-dienoyl-CoA reductase 2
External IDs	OMIM: 615839 MGI: 1347059 HomoloGene: 22223 GeneCards: DECR2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	412,487 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,309,311 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; renal cortex; ; kidney; ; body of pancreas; ; gastrocnemius muscle; ; body of stomach; ; fundus; ; left uterine tube; ; prostate;
	Top expressed in
	interventricular septum; ; left lobe of liver; ; ventromedial nucleus; ; mammillary body; ; proximal tubule; ; seminal vesicula; ; parotid gland; ; lateral geniculate nucleus; ; duodenum; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; signaling receptor binding ; 2,4-dienoyl-CoA reductase (NADPH) activity ; trans-2-enoyl-CoA reductase (NADPH) activity ;
Cellular component	peroxisomal membrane ; peroxisome ; cytosol ;
Biological process	unsaturated fatty acid biosynthetic process ; fatty acid metabolic process ; lipid metabolism ; fatty acid beta-oxidation using acyl-CoA oxidase ; protein targeting to peroxisome ;
	Sources:Amigo / QuickGO
Orthologs
	26063
	26378
	ENSG00000242612 ; ENSG00000274296
	ENSMUSG00000036775
	Q9NUI1
	Q9WV68
	NM_020664
	NM_011933
	NP_065715
	NP_036063
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Peroxisomal 2,4-dienoyl-CoA reductase is an enzyme that in humans is encoded by the DECR2 gene.^[5]^[6]^[7]

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References

1 2 3 ENSG00000274296 GRCh38: Ensembl release 89: ENSG00000242612, ENSG00000274296 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036775 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ De Nys K, Meyhi E, Mannaerts GP, Fransen M, Van Veldhoven PP (Aug 2001). "Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase". Biochim Biophys Acta. 1533 (1): 66–72. doi:10.1016/s1388-1981(01)00141-x. PMID 11514237.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.
↑ "Entrez Gene: DECR2 2,4-dienoyl CoA reductase 2, peroxisomal".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID 11157797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID 15616553.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000274296 GRCh38: Ensembl release 89: ENSG00000242612, ENSG00000274296 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036775 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11514237-5] De Nys K, Meyhi E, Mannaerts GP, Fransen M, Van Veldhoven PP (Aug 2001). "Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase". Biochim Biophys Acta. 1533 (1): 66–72. doi:10.1016/s1388-1981(01)00141-x. PMID 11514237.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.

[entrez-7] "Entrez Gene: DECR2 2,4-dienoyl CoA reductase 2, peroxisomal".

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[7]

DECR2

Related Research Articles

References

Further reading