DEFB105A

DEFB105A
Identifiers
Aliases	DEFB105A , BD-5, DEFB-5, DEFB105, defensin beta 105A
External IDs	MGI: 1924924 HomoloGene: 17531 GeneCards: DEFB105A
Gene location (Human)
Chr.	Chromosome 8 (human)
End	7,823,880 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	19,164,866 bp
RNA expression pattern
	Top expressed in
	muscle tissue; ; cell; ; blood; ; monocyte; ; renal cortex; ; endometrium; ; exocrine gland; ; cervix; ; cerebral cortex; ; leg;
	Top expressed in
	zone of skin; ; testicle;
	More reference expression data
	n/a
Orthologs
	245908
	77674
	ENSG00000186562
	ENSMUSG00000043787
	Q8NG35
	Q8K4N3
	NM_152250
	NM_152802
	NP_689463
	NP_690015
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 20, 2023

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.^[5]^[6]^[7]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186562 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043787 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi: 10.1073/pnas.042692699 . PMC 122330 . PMID 11854508.
↑ Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587 . PMID 12734011.
1 2 "Entrez Gene: DEFB105A defensin, beta 105A".

Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract". Physiol. Genomics. 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865. S2CID 22355626.
Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
Taudien S, Galgoczy P, Huse K, et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence". BMC Genomics. 5 (1): 92. doi:10.1186/1471-2164-5-92. PMC 544879 . PMID 15588320.
Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC 1180683 . PMID 12916016.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice". J. Immunol. 169 (5): 2516–23. doi: 10.4049/jimmunol.169.5.2516 . PMID 12193721.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186562 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043787 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11854508-5] Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. doi: 10.1073/pnas.042692699 . PMC 122330 . PMID 11854508.

[pmid12734011-6] Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587 . PMID 12734011.

[entrez-7] 1 2 "Entrez Gene: DEFB105A defensin, beta 105A".

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DEFB105A

Related Research Articles

References

Further reading