DEFB119

DEFB119
Identifiers
Aliases	DEFB119 , DEFB-19, DEFB-20, DEFB120, ESC42-RELA, ESC42-RELB, DEFB20, defensin beta 119
External IDs	OMIM: 615997; MGI: 2385955; HomoloGene: 17045; GeneCards: DEFB119; OMA:DEFB119 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.21 Start 31,377,164 bp [1] End 31,390,590 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 152,418,006 bp [2] End 152,422,232 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis right testis left testis testicle tail of epididymis buccal mucosa cell caput epididymis sperm right coronary artery retinal pigment epithelium Top expressed in Gonadal ridge seminiferous tubule spermatocyte embryo spermatid cumulus cell efferent ductule epithelium of seminiferous tubule of testis Sertoli cell morula More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding Cellular component extracellular region cell surface Biological process defense response to bacterium defense response innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245932 246700 Ensembl ENSG00000180483 ENSMUSG00000050645 UniProt Q8N690 Q8K3I8 RefSeq (mRNA) NM_001271209 NM_153289 NM_153323 NM_145157 RefSeq (protein) NP_001258138 NP_695021 NP_697018 NP_660139 Location (UCSC) Chr 20: 31.38 – 31.39 Mb Chr 2: 152.42 – 152.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-defensin 119 is a protein that in humans is encoded by the DEFB119 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000180483 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050645 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi: 10.1073/pnas.042692699 . PMC   122330 . PMID   11854508.
6. "Entrez Gene: DEFB119 defensin, beta 119".

Further reading

• Lehrer RI, Ganz T (2002). "Defensins of vertebrate animals". Curr. Opin. Immunol. 14 (1): 96–102. doi:10.1016/S0952-7915(01)00303-X. PMID   11790538.
• Raj PA, Dentino AR (2002). "Current status of defensins and their role in innate and adaptive immunity" . FEMS Microbiol. Lett. 206 (1): 9–18. doi: 10.1111/j.1574-6968.2002.tb10979.x . PMID   11786250.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yamamoto M, Matsui Y (2003). "Testis-specific expression of a novel mouse defensin-like gene, Tdl". Mech. Dev. 116 (1–2): 217–21. doi:10.1016/S0925-4773(02)00144-2. PMID   12128228. S2CID   15160486.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.