DEFB129

DEFB129
Identifiers
Aliases	DEFB129 , C20orf87, DEFB-29, DEFB29, bA530N10.3, hBD-29, defensin beta 129
External IDs	MGI: 3644405 HomoloGene: 83411 GeneCards: DEFB129
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 227,258 bp [1] End 229,886 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 152,300,975 bp [2] End 152,306,540 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis sperm seminal vesicula caput epididymis sural nerve integument abdominal segment of trunk arthropod abdomen integument zone of skin Top expressed in ovary hypothalamus secondary oocyte testicle lung white adipose tissue esophagus olfactory bulb More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 140881 629114 Ensembl ENSG00000125903 ENSMUSG00000074681 UniProt Q9H1M3 Q30KP0 RefSeq (mRNA) NM_080831 NM_001037933 RefSeq (protein) NP_543021 NP_001033022 Location (UCSC) Chr 20: 0.23 – 0.23 Mb Chr 2: 152.3 – 152.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene. ^{[5] [6]}

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125903 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074681 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved β-defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi: 10.1073/pnas.042692699 . PMC   122330 . PMID   11854508.
6. "Entrez Gene: DEFB129 defensin, beta 129".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID   12620395.
• Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. CiteSeerX   10.1.1.108.7808 . doi:10.1165/rcmb.2002-0205OC. PMID   12600824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.