DHX16

DHX16
Identifiers
Aliases	DHX16 , DBP2, DDX16, PRO2014, PRP8, PRPF2, Prp2, DEAH-box helicase 16, NMOAS
External IDs	OMIM: 603405; MGI: 1916442; HomoloGene: 2658; GeneCards: DHX16; OMA:DHX16 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 30,653,119 bp [1] End 30,673,006 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 36,190,711 bp [2] End 36,203,562 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte left testis right testis right uterine tube right lobe of thyroid gland left lobe of thyroid gland spleen minor salivary glands duodenum Top expressed in neural layer of retina granulocyte morula morula thymus ventricular zone epiblast blastocyst medullary collecting duct hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding protein binding ATP binding helicase activity hydrolase activity nucleic acid binding ATPase activity RNA binding 3'-5' RNA helicase activity Cellular component spliceosomal complex nucleus cytoplasm nucleoplasm U2-type precatalytic spliceosome Biological process mRNA processing RNA splicing mRNA splicing, via spliceosome metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8449 69192 Ensembl ENSG00000233561 ENSG00000206486 ENSG00000233418 ENSG00000231377 ENSG00000227222 ENSG00000204560 ENSG00000233049 ENSG00000226171 ENSMUSG00000024422 UniProt O60231 Q5SQH5 n/a RefSeq (mRNA) NM_001164239 NM_003587 NM_001363515 NM_026987 RefSeq (protein) NP_001157711 NP_003578 NP_001350444 n/a Location (UCSC) Chr 6: 30.65 – 30.67 Mb Chr 17: 36.19 – 36.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene. ^{[5] [6]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. ^[6]

References

1. ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 GRCh38: Ensembl release 89: ENSG00000233561, ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024422 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Imamura O, Saiki K, Tani T, Ohshima Y, Sugawara M, Furuichi Y (Jun 1998). "Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8". Nucleic Acids Res. 26 (9): 2063–8. doi:10.1093/nar/26.9.2063. PMC   147520 . PMID   9547260.
6. "Entrez Gene: DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. CiteSeerX   10.1.1.610.1181 . doi: 10.1093/dnares/5.1.31 . PMID   9628581.