| DIS3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | DIS3 , 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607533 MGI: 1919912 HomoloGene: 6910 GeneCards: DIS3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. [5] [6] Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells. [7] [8]
The exosome complex is a multi-protein intracellular complex capable of degrading various types of RNA molecules. Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome carries out similar functions.
Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.
Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.
Ribonuclease P protein subunit p20 is an enzyme that in humans is encoded by the POP7 gene.
Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene.
Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.
Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.
Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.
Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene.
Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.
Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.
Superkiller viralicidic activity 2-like 2 is a protein that in humans is encoded by the SKIV2L2 gene.
3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.
Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex.
Ribonuclease P protein subunit p14 is an enzyme that in humans is encoded by the RPP14 gene.
Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.
U3 small nucleolar RNA-interacting protein 2 is a protein that in humans is encoded by the RRP9 gene.
KIAA0930 is a protein that, in humans, is encoded by the KIAA0930 gene.
Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.
DIS3-like exonuclease 1 is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.
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